Chronic hypersensitivity pneumonitis: real world diagnostic criteria

Sharma, Ashutosh; Ferraro, Vincent; Renzoni, Elisabetta; Morisset, Julie

doi:10.1097/mcp.0000000000000799

Cited by 4 publications

(4 citation statements)

References 64 publications

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“…These results are comparable with our finding that image parameter was superior to physiologic parameters for predicting mortality in patients with fibrotic HP. These results can be explained by the fact that because HP is a kind of airway involvement disease, lung function abnormalities do not necessarily mean lung parenchymal change ( 41 ). Therefore, our results suggest that radiological parameters can be used as useful tools to overcome the limitations of physiologic parameters for predicting mortality in patients with HP.…”

Section: Discussionmentioning

confidence: 99%

Fibrosis score predicts mortality in patients with fibrotic hypersensitivity pneumonitis

Kang

Song

2023

Front. Med.

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BackgroundVariable clinical courses make it challenging to predict mortality resulting from fibrotic hypersensitivity pneumonitis (HP). This study evaluated the usefulness of radiologic parameters for predicting mortality in patients with fibrotic HP.MethodsClinical data and high-resolution computed tomography (HRCT) images, which were scored for reticulation, honeycombing, ground glass opacity (GGO), consolidation, and mosaic attenuation (MA) by visual assessment, were retrospectively analyzed in a total of 101 patients with fibrotic HP (all biopsy-proven cases). Fibrosis score was defined as the sum of reticulation and honeycombing scores.ResultsThe mean age of the 101 patients was 58.9 years, and 60.4% were females. During the follow-up (median: 55.5 months; interquartile range: 37.7–89.0 months), the 1-, 3-and 5-year mortality rates were 3.9, 16.8, and 32.7%, respectively. The non-survivors were older and had significantly lower lung function and minimum oxygen saturation during the 6-min walk test than the survivors. The non-survivors had higher scores of reticulation, honeycombing, GGO, fibrosis, and MA on HRCT than survivors. In the multivariable Cox analysis, reticulation, GGO, and fibrosis scores were independent prognostic factors for mortality in patients with fibrotic HP, as well as age. Fibrosis score showed great performance for predicting the 5-year mortality (AUC = 0.752, p < 0.001) and higher mortality was recorded for patients with high fibrosis score (≥12.0%) (the mean survival time: 58.3 vs. 146.7 months, p < 0.01) than those without.ConclusionOur results suggest that radiologic fibrosis score may be a useful predictor of mortality in patients with fibrotic HP.

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Section: Discussionmentioning

confidence: 99%

Fibrosis score predicts mortality in patients with fibrotic hypersensitivity pneumonitis

Kang

Song

2023

Front. Med.

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“…Several studies have investigated the clinical features and likely predictors in patients at high risk of PF-ILD at baseline (Kolb and Vašáková, 2019). Certain conditions, such as FHP (which is not associated with any specific antigen) and increasing age predispose to PF-ILD (Sharma et al, 2021;Churg, 2022). Smoking status was a risk factor for rheumatoid arthritis-ILD (RA-ILD) or primary Sjögren syndrome associated with ILD (Johnson, 2017;.…”

Section: Prognostic Predictive Characteristics In Patients With Fibro...mentioning

confidence: 99%

Pulmonary Fibrosis: One Manifestation, Various Diseases

2022

Frontiers Research Topics

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Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers Journal SeriesThe Frontiers Journal Series is a multi-tier and interdisciplinary set of open-access, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers Journal Series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to QualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation.

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“…Pulmonary fibrosis can be easily confused with IPF 7 , 8 . Since subtypes of hypersensitivity pneumonitis, namely acute, subacute, and chronic, are still vaguely defined, there is need for clinicians to obtain patients’ clinical history, perform high-resolution computed tomography (HRCT), histopathology and multiple discipline diagnosis (MDD) 9 , 10 . The histopathological pattern of CHP includes a type called usual interstitial pneumonia (UIP), which exhibits a course similar to IPF.…”

Section: Introductionmentioning

confidence: 99%

5-methyladenosine regulators play a crucial role in development of chronic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis

Zhou

Sun

et al. 2023

Sci Rep

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Abstract5-methyladenosine (m5C) modification regulates gene expression and biological functions in oncologic areas. However, the effect of m5C modification in chronic hypersensitivity pneumonitis (CHP) and idiopathic pulmonary fibrosis (IPF) remains unknown. Expression data for 12 significant m5C regulators were obtained from the interstitial lung disease dataset. Five candidate m5C regulators, namely tet methylcytosine dioxygenase 2, NOP2/Sun RNA methyltransferase 5, Y-box binding protein 1, tRNA aspartic acid methyltransferase 1, and NOP2/Sun RNA methyltransferase 3 were screened using random forest and nomogram models to predict risks of pulmonary fibrosis. Next, we applied the consensus clustering method to stratify the samples with different m5C patterns into two groups (cluster A and B). Finally, we calculated immune cell infiltration scores via single-sample gene set enrichment analysis, then compared immune cell infiltration, related functions as well as the expression of programmed cell death 1 (PD-1, PDCD1) and programmed death protein ligand-1 (PD-L1, CD274) between the two clusters. Principal component analysis of m5C-related scores across the 288 samples revealed that cluster A had higher immune-related expression than B. Notably, T helper cell (Th) 2 type cytokines and Th1 signatures were more abundant in clusters A and B, respectively. Our results suggest that m5C is associated with and plays a crucial role in development of pulmonary fibrosis. These m5C patterns could be potential biomarkers for identification of CHP and IPF, and guide future development of immunotherapy or other new drugs strategies for pulmonary fibrosis.

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Chronic hypersensitivity pneumonitis: real world diagnostic criteria

Cited by 4 publications

References 64 publications

Fibrosis score predicts mortality in patients with fibrotic hypersensitivity pneumonitis

Fibrosis score predicts mortality in patients with fibrotic hypersensitivity pneumonitis

Pulmonary Fibrosis: One Manifestation, Various Diseases

5-methyladenosine regulators play a crucial role in development of chronic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis

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