Chronic hypertension in pregnancy

Battarbee, Ashley N.; Sinkey, Rachel G.; Harper, Lorie M.; Oparil, Suzanne; Tita, Alan T.N.

doi:10.1016/j.ajog.2019.11.1243

Cited by 100 publications

(101 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Beta‐blockers are the most commonly prescribed antihypertensive drugs for pregnant women 34 . Thus, it is important to determine whether β‐blocker exposure is associated with an increased risk of congenital malformations in the offspring of women prescribed β‐blockers during early pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Risk of congenital malformations in offspring of women using β‐blockers during early pregnancy: An updated meta‐analysis of observational studies

Wu¹,

Yao²,

Xu³

et al. 2020

Brit J Clinical Pharma

View full text Add to dashboard Cite

Aims Beta‐blockers are commonly used to treat hypertension that arises during pregnancy. However, reproductive safety concerns have been expressed. Here, we investigated whether the use of β‐blockers during early pregnancy increased the risk of congenital malformations. Methods A systematic literature search was performed in PubMed, Embase and Cochrane Library to identify relevant studies published from database inception until February 2020. Observational studies evaluating associations between maternal β‐blocker use and congenital malformations were included in this meta‐analysis. Two reviewers independently extracted data and assessed study quality. Meta‐analysis of outcomes was performed and a summary odds ratio (OR) was calculated with consideration of heterogeneity. Results Twenty observational studies were identified. Beta‐blocker use during early pregnancy was not associated with an increased risk of congenital malformations (OR = 1.01, 95% confidence interval [CI] = 0.93–1.09). Subgroup analysis of organ‐specific malformations revealed that β‐blocker use was associated with an increased risk of heart malformations (OR = 1.29, 95% CI = 1.02–1.63) and an increased risk of cleft lip or palate (OR = 1.5, 95% CI = 1.18–1.91); however, these associations (OR = 1.11, 95% CI = 0.94–1.32 for heart malformations; OR = 1.34, 95% CI = 0.98–1.85 for cleft lip or palate) disappeared when the adjusted data were pooled. Beta‐blocker use was not associated with increased risks of central nervous system malformations, neural tube defects or hypospadias. Conclusion Exposure to β‐blockers during early pregnancy does not appear to be associated with congenital malformations or heart malformations in offspring. Other organ‐specific congenital malformations should be evaluated in further studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk of congenital malformations in offspring of women using β‐blockers during early pregnancy: An updated meta‐analysis of observational studies

Wu¹,

Yao²,

Xu³

et al. 2020

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…Several studies revealed that labetalol is a preferred antihypertensive agent in chronic hypertension during pregnancy, especially in severe cases since methyldopa has a mild effect on hypertension with slow onset and nifedipine has many adverse effects. 10,36,37 β-blockers, according to JNC 8, are no longer recommended as first line agents to treat hypertension in patients without compelling indication owing to their association with greater risk of cardiovascular death when compared with amlodipine-based regimen. 38 In this study, the adherence to this recommendation was reported by 64% (n=249) of the Yemeni physicians.…”

Section: Discussionmentioning

confidence: 99%

<p>Awareness of Physicians in Yemen Toward High Blood Pressure Management According to the Eighth Joint National Committee (JNC 8) Guideline</p>

Halboup¹,

Othman²,

Battah³

et al. 2020

IJGM

View full text Add to dashboard Cite

Background: Hypertension is a common public health problem that impacts more than onethird of the world population. Awareness of physicians towards the guidelines of high blood pressure management is an essential step to reduce the consequences of high blood pressure. Objective: This study was aimed to assess the awareness of physicians towards high blood pressure treatment according to the recent report of the Joint National Committee (JNC8) guideline. Methods: A self-administered questionnaire was distributed to 400 physicians during the period from February to April 2017. Physicians were recruited from public and private hospitals as well as clinics. A validated questionnaire that incorporated the changes seen in JNC 8, as well as the specific modality of hypertension management based on other guidelines, was administered to the participating physicians. Results: Three hundred and eighty-nine physicians completed the questionnaire; with all the interviewed physicians have ever heard about JNC 8. The practice of general practitioners (GPs) was significantly deviated from the recommended guideline of blood pressure management as compared to consultants, specialists, and residents. Additionally, certain variations were found among consultants, specialists, and residents with slight superiority of consultants towards most aspects. Conclusion: The finding of this study highlights an inadequate knowledge of GPs in Yemen towards high blood pressure management guidelines. The findings of this study emphasize the necessity for continuous medical education programs that are specially designed to target GPs. Continued update of medical curricula in Yemeni universities is also needed.

show abstract

“…Association between neuraxial analgesia and postpartum opioid use following vaginal delivery: the conundrum remains TO THE EDITORS: Recently the very innovative and intriguing research letter by Badreldin et al reports findings from a retrospective analysis demonstrating intrapartum neuraxial analgesia may not influence overall postdelivery opioid use in the vaginal delivery settings. 1 We have some comments.…”

Section: Re Letter To the Editor: Prehypertension Is Associated With mentioning

confidence: 99%

“…Prehypertension is associated with multiple poor maternal and fetal outcomes TO THE EDITORS: I read with interest the paper titled "Chronic Hypertension in Pregnancy" accepted for publication in the Journal in 2019. 1 The authors wrote a thorough excursus thought classification, diagnosis, and treatment of this common maternal obstetric pathology.…”

mentioning

confidence: 99%

Prehypertension is associated with multiple poor maternal and fetal outcomes

Sisti

2020

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

Chronic hypertension in pregnancy

Cited by 100 publications

References 66 publications

Risk of congenital malformations in offspring of women using β‐blockers during early pregnancy: An updated meta‐analysis of observational studies

Risk of congenital malformations in offspring of women using β‐blockers during early pregnancy: An updated meta‐analysis of observational studies

<p>Awareness of Physicians in Yemen Toward High Blood Pressure Management According to the Eighth Joint National Committee (JNC 8) Guideline</p>

Prehypertension is associated with multiple poor maternal and fetal outcomes

Contact Info

Product

Resources

About