2012
DOI: 10.1007/s11010-011-1210-x
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Chronic hypobaric hypoxia mediated skeletal muscle atrophy: role of ubiquitin–proteasome pathway and calpains

Abstract: The most frequently reported symptom of exposure to high altitude is loss of body mass and decreased performance which has been attributed to altered protein metabolism affecting skeletal muscles mass. The present study explores the mechanism of chronic hypobaric hypoxia mediated skeletal muscle wasting by evaluating changes in protein turnover and various proteolytic pathways. Male Sprague-Dawley rats weighing about 200 g were exposed to hypobaric hypoxia (7,620 m) for different durations of exposure. Physica… Show more

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Cited by 90 publications
(71 citation statements)
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References 39 publications
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“…The sustained activation status of protein synthesis and degradation and the continuous loss of tissue weight, compared with control and pair-fed animals, may reflect an elevated protein turnover and subsequent higher energy consumption under sustained hypoxic conditions. Although future studies should address actual protein synthesis and degradation rates and compare them to the observed changes in protein turnover signaling, elevated protein turnover rates in response to hypoxia described by Chaudhary et al (6) correspond with the increased expression of genes involved in protein turnover that we report here.…”
Section: L88supporting
confidence: 75%
See 1 more Smart Citation
“…The sustained activation status of protein synthesis and degradation and the continuous loss of tissue weight, compared with control and pair-fed animals, may reflect an elevated protein turnover and subsequent higher energy consumption under sustained hypoxic conditions. Although future studies should address actual protein synthesis and degradation rates and compare them to the observed changes in protein turnover signaling, elevated protein turnover rates in response to hypoxia described by Chaudhary et al (6) correspond with the increased expression of genes involved in protein turnover that we report here.…”
Section: L88supporting
confidence: 75%
“…It has been demonstrated previously that hypobaric hypoxia results in muscle atrophy (36,53). Although elevated protein turnover has been shown in rats under hypobaric hypoxia (6), changes in signaling pathways of protein synthesis and degradation were not investigated. Because hypobaric hypoxia involves effects of both oxygen limitation and barometric pressure reduction, the latter may confound the interpretation of the effects of hypoxia per se.…”
Section: L87 Hypoxia-induced Muscle Atrophy Modulates Protein Turnovementioning
confidence: 99%
“…Although muscle atrophy in lung disease can be caused by several mechanisms discussed above (that is, sepsis, inflammation and reduced physical activity) (TABLE 1), other factors, especially hypoxia, may also contribute. Rats exposed to hypoxia showed decreased exercise capacity and muscle mass 149 and increased proteasome activity 150 . In humans, chronic exposure to high altitude is associated with decreased muscle mass 151 .…”
Section: Sarcopeniamentioning
confidence: 99%
“…Early studies associated the ascent and extended periods spent at high altitude (>5500 m) with up to a 15% muscle mass loss [45] and reduced strength gains (−6.4%) compared to normoxia [46]. Explanations for this have included altitude-induced protein synthesis rate reduction [47, 48] or increased protein degradation during exercise [49], leading to a negative synthesis/degradation of protein balance. Nevertheless, training camps are usually held at moderate altitudes (1800–2500 m), while no data are reported in scientific literature about hypertrophic resistance training during intermittent or chronic periods at terrestrial altitude; protein metabolism seems to be unaffected by O 2 availability at moderate simulated altitudes in acute NH [50].…”
Section: Hypertrophy Trainability In Conditions Of Hypoxiamentioning
confidence: 99%