Chronic<i>Schistosoma mekongi</i>in a Traveler—A Case Report and Review of the Literature

Campa, Pauline; Develoux, M.; Belkadi, G.; Magne, Denis; Lame, Charles; Carayon, Marie‐Jeanne; Girard, Pierre‐Marie

doi:10.1111/jtm.12137

Cited by 12 publications

(4 citation statements)

References 11 publications

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“…The infected snail prevalence was very low with 0.01% ( n = 29,583) of collected snails being positive [123]. More recent cases have been identified in returning travelers who visited these historically endemic areas, including a Belgian visitor to Khong Island in 2013 and a French woman who was exposed to freshwater habitats in southern Lao PDR [205,206]. These cases indicate that transmission is ongoing.…”

Section: Current and Historical Status Of Schistosomiasis In Asiamentioning

confidence: 99%

Asian Schistosomiasis: Current Status and Prospects for Control Leading to Elimination

et al. 2019

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Schistosomiasis is an infectious disease caused by helminth parasites of the genus Schistosoma. Worldwide, an estimated 250 million people are infected with these parasites with the majority of cases occurring in sub-Saharan Africa. Within Asia, three species of Schistosoma cause disease. Schistosoma japonicum is the most prevalent, followed by S. mekongi and S. malayensis. All three species are zoonotic, which causes concern for their control, as successful elimination not only requires management of the human definitive host, but also the animal reservoir hosts. With regard to Asian schistosomiasis, most of the published research has focused on S. japonicum with comparatively little attention paid to S. mekongi and even less focus on S. malayensis. In this review, we examine the three Asian schistosomes and their current status in their endemic countries: Cambodia, Lao People’s Democratic Republic, Myanmar, and Thailand (S. mekongi); Malaysia (S. malayensis); and Indonesia, People’s Republic of China, and the Philippines (S. japonicum). Prospects for control that could potentially lead to elimination are highlighted as these can inform researchers and disease control managers in other schistosomiasis-endemic areas, particularly in Africa and the Americas.

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Section: Current and Historical Status Of Schistosomiasis In Asiamentioning

confidence: 99%

Asian Schistosomiasis: Current Status and Prospects for Control Leading to Elimination

et al. 2019

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“…Schistosoma mekongi is the causative agent of intestinal schistosomiasis in the lower Mekong river region, especially in Laos and northern Cambodia [1]. Infections in other parts of the world are occasionally reported owing to human migration and travel-related illness [3][4][5]. Clinical manifestations of Mekong schistosomiasis include abdominal pain, bloody stool, diarrhea and liver enlargement, resulting in fatality in severe cases [1,6].…”

Section: Introductionmentioning

confidence: 99%

Effect of Praziquantel on Schistosoma mekongi Proteome and Phosphoproteome

et al. 2020

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Schistosoma mekongi causes schistosomiasis in southeast Asia, against which praziquantel (PZQ) is the only treatment option. PZQ resistance has been reported, thus increasing the requirement to understand mechanism of PZQ. Herein, this study aimed to assess differences in proteome and phosphoproteome of S. mekongi after PZQ treatment for elucidating its action. Furthermore, key kinases related to PZQ effects were predicted to identify alternative targets for novel drug development. Proteomes of S. mekongi were profiled after PZQ treatment at half maximal inhibitory concentration and compared with untreated worms. A total of 144 proteins were differentially expressed after treatment. In parallel, immunohistochemistry indicated a reduction of phosphorylation, with 43 phosphoproteins showing reduced phosphorylation, as identified by phosphoproteomic approach. Pathway analysis of mass spectrometric data showed that calcium homeostasis, worm antigen, and oxidative stress pathways were influenced by PZQ treatment. Interestingly, two novel mechanisms related to protein folding and proteolysis through endoplasmic reticulum-associated degradation pathways were indicated as a parasiticidal mechanism of PZQ. According to kinase–substrate predictions with bioinformatic tools, Src kinase was highlighted as the major kinase related to the alteration of phosphorylation by PZQ. Interfering with these pathways or applying Src kinase inhibitors could be alternative approaches for further antischistosomal drug development.

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“…Of these, 1.8 million people are considered to be directly exposed to infection through water contact activities [ 106 , 107 ]. Approximately 140,000 people are estimated to be at risk for S. mekongi infection (80,000 people in Cambodia and 60,000 in Lao PDR) [ 102 , 108 ].…”

Section: Recent Studies On Natural Resources Of Affected Regions Amentioning

confidence: 99%

Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions

Albuquerque

Mahomoodally

Lobine

et al. 2020

Biology

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Schistosomiasis, a parasitic disease caused by trematodes of the genus Schistosoma, is the second most prevalent parasitic disease in the world. It affects around 200 million people. Clinical treatment, prophylaxis, and prevention are performed in countries susceptible to schistosomiasis. In the pharmacological treatment for an acute form of schistosomiasis, the use of antiparasitics, mainly praziquantel, is more common. As an alternative way, prevention methods such as reducing the population of intermediate hosts (mollusks) with molluscicides are important in the control of this disease by interrupting the biological cycle of this etiological parasite. Despite the importance of pharmacological agents and molluscicides, they have side effects and environmental toxicity. In addition, they can lead to the development of resistance enhancing of parasites, and lead to the search for new and effective drugs, including resources of vegetal origin, which in turn, are abundant in the affected countries. Thus, the purpose of this review is to summarize recent studies on botanical products with potential for the control of schistosomiasis, including anti-Schistosoma and molluscicide activities. In addition, species and plant derivatives according to their origin or geographical importance indicating a possible utility of local resources for countries most affected by the disease are presented.

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ChronicSchistosoma mekongiin a Traveler—A Case Report and Review of the Literature

Cited by 12 publications

References 11 publications

Asian Schistosomiasis: Current Status and Prospects for Control Leading to Elimination

Asian Schistosomiasis: Current Status and Prospects for Control Leading to Elimination

Effect of Praziquantel on Schistosoma mekongi Proteome and Phosphoproteome

Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions

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