Chronic inflammation is a key to inducing liver injury in blunt snout bream (Megalobrama amblycephala) fed with high-fat diet

Dai, Yong‐Jun; Cao, Xiufei; Zhang, Dingdong; Li, Xiangfei; Liu, Wenbin; Jiang, Guang‐Zhen

doi:10.1016/j.dci.2019.03.009

Cited by 89 publications

(46 citation statements)

References 58 publications

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“…Previous studies suggest high‐fat diet may affect energy metabolism, leading to fat deposition and lipid peroxidation, finally inducing inflammatory response, apoptosis and reactive oxygen species production in fish and mammal (Dai et al, 2019; Guo et al, 2019; Tang et al, 2019; Vial et al, 2011; Weihong et al, 2019). MDA, a product of lipid peroxidation, is considered a surrogate marker of oxidative stress (Koruk et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…In present study, SOD activities in plasma and liver decreased in Japanese bass fed a high‐fat diet. SOD activities were also decreased in shrimp and largemouth bass fed high‐fat diet (Xie et al, 2019; Yin et al, 2020), and the oxidative defence system of tilapia and blunt snout bream were impaired by high‐fat diet (Jia et al, 2020, Dai et al, 2019b). These results indicated that fish may have limited ability to alleviate oxidative stress induced by high‐fat diets.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the expression of Il1β , tgfβ and tnfα were significantly increased in Japanese seabass fed high‐fat diet, which indicated high dietary lipid activated inflammation response of fish. Inflammation related gene expressions were also up‐regulated in black seabream, blunt snout bream and tilapia fed high‐fat diet (Dai et al, 2019; Jia et al, 2020; Jin et al, 2020). Previous research reported that high‐fat‐diet‐induced inflammatory response closely associated with endoplasmic reticulum stress (ERS) (Jin et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…High‐fat diet firstly induced the production of reactive oxygen species, lipid peroxides and pro‐inflammatory factors (Yin et al, 2020). Long‐term intake of high‐fat diet then activated multiple immune signalling pathways such as c‐jun N‐terminal kinase (JNK), nuclear factor κB (NF‐κB) and toll‐like receptors (TLRs) (Jia et al, 2020, Jin et al, 2020, Wei et al, 2017), and finally induced the DNA damage and apoptosis (Dai et al, 2019). Until now, the tolerance of Japanese seabass to high‐fat diet has not been evaluated, and the molecular mechanisms of high‐fat‐diet‐induced inflammation in Japanese seabass have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Dietary lipid levels affected growth performance, lipid accumulation, inflammatory response and apoptosis of japanese seabass (lateolabraxjaponicus)

Xie

Lin

et al. 2021

Aquacult. Nutr.

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An eight weeks feeding trial was conducted to investigate the effects of dietary lipid levels on growth performance, lipid metabolism and immune response of Japanese seabass (Lateolabrax japonicus). Five diets were formulated with gradient dietary lipid levels (79.6, 104.4, 129.1, 154.9 and 178.6 g kg−1). Results revealed that growth and feed utilization of fish were significantly lower in group L178.6 than other groups (p < 0.05). Lipid accumulation in whole body, muscle and intraperitoneal were increased with increasing dietary lipid levels. The mRNA levels of adipose triglyceride lipase, carnitine palmitoyl transferase 1, acetyl CoA carboxylase, cholesterol 7 alpha‐hydroxylase and retinoid X receptor in liver were also increased with increasing dietary lipid levels (p < 0.05). The mRNA levels of apolipoprotein A1 and peroxisome proliferator activating receptor α were higher in fish fed L178.6 than those fed other diets. Oxidative stress in plasma and liver were induced when dietary lipid exceed 154.9 g kg−1. L154.9 and L178.6 significantly increased the inflammatory related gene expression of fish. These results suggested that high‐fat diet impaired the growth performance and induced lipid accumulation, inflammation and apoptosis of Japanese seabass. The suitable dietary lipid level of Japanese seabass may not exceed 129.1 g kg−1.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dietary lipid levels affected growth performance, lipid accumulation, inflammatory response and apoptosis of japanese seabass (lateolabraxjaponicus)

Xie

Lin

et al. 2021

Aquacult. Nutr.

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“…The use of fat‐rich feeds has made fish farming more cost‐effective because protein is a relatively expensive source of energy (Cao et al., 2019; Dai et al., 2019). Supplementing diets with fat enable the protein to be “spared” for the synthesis of new tissue (Lu et al., 2013; Xu et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation of glycyrrhetinic acid benefit growth performance and lipid metabolism in blunt snout bream (Megalobrama amblycephala) juveniles

Abasubong

Adjoumani

et al. 2020

Aquacult. Nutr.

Self Cite

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The use of fat-rich feeds has made fish farming more cost-effective because protein is a relatively expensive source of energy (Cao et al., 2019; Dai et al., 2019). Supplementing diets with fat enable the protein to be "spared" for the synthesis of new tissue (Lu et al., 2013; Xu et al., 2015). Indeed, dietary lipid levels support higher growth rates and extra dietary protein in some species. However, suboptimal and/or excess level of lipid may have an adverse effect on growth and unwanted fat deposition in the liver, inducing a condition referred to as "fatty liver" which often correlates with mortality (Abasubong et al., 2018; Desouky et al., 2020; Hillestad & Johnsen, 1994). Recently, several additives have been substantiated to be effective in controlling the accumulation of extra fat in the fish tissues and also regulate the expressions of the primary genes involved in lipid metabolism without having any adverse on growth performance. For instance, Adjoumani et al. (2017) reported that dietary betaine improved growth, alleviated fat accumulation and regulated key genes involved in lipid metabolism in the liver of blunt snout (M. amblycephala) fed high-fat diet (HFD). Abasubong

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Dietary Sodium Butyrate Supplementation Attenuates the Detrimental Effects of High‐Fat Diets on Growth Performance, Liver Health, and Disease Resistance in Grass Carp

et al. 2022

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An 8‐week experiment was conducted to investigate the effects of sodium butyrate (NaBT) inclusion in high‐fat (HF) diets on growth performance, liver health, and disease resistance in Grass Carp Ctenopharyngodon idella. Three diets (Control diet containing crude lipid at 58 g/kg, HF diet with 108‐g/kg crude lipid, and NaBT diet with 108‐g/kg crude lipid and 1‐g/kg NaBT) were randomly assigned to nine tanks with 30 fish (9.50 ± 0.06 g) in each tank. After the feeding trial, disease resistance was assessed by injecting the fish with Aeromonas hydrophila. Compared to the Control diet group, the HF diet group showed lower specific growth rate, feed efficiency, and survival rate (15.7%) after the A. hydrophila challenge; significantly higher activity levels of alanine aminotransferase and aspartate aminotransferase in plasma; higher malondialdehyde content; higher messenger RNA (mRNA) expression of interleukin‐8, cysteinyl aspartate specific protease (caspase) 9, and caspase 3; lower activity level of glutathione peroxidase; and lower mRNA expression of nuclear factor erythroid 2‐related factor 2 in liver. However, the NaBT diet significantly increased fish growth performance and survival rate (39.7%) after the A. hydrophila challenge and reduced hepatic oxidative stress, inflammation, and apoptosis compared to the HF diet. In conclusion, NaBT can ameliorate the detrimental effects of HF diets on fish growth performance and fish health.

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Chronic inflammation is a key to inducing liver injury in blunt snout bream (Megalobrama amblycephala) fed with high-fat diet

Cited by 89 publications

References 58 publications

Dietary lipid levels affected growth performance, lipid accumulation, inflammatory response and apoptosis of japanese seabass (lateolabraxjaponicus)

Dietary lipid levels affected growth performance, lipid accumulation, inflammatory response and apoptosis of japanese seabass (lateolabraxjaponicus)

Dietary supplementation of glycyrrhetinic acid benefit growth performance and lipid metabolism in blunt snout bream (Megalobrama amblycephala) juveniles

Dietary Sodium Butyrate Supplementation Attenuates the Detrimental Effects of High‐Fat Diets on Growth Performance, Liver Health, and Disease Resistance in Grass Carp

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