Chronic inflammation towards cancer incidence: A systematic review and meta-analysis of epidemiological studies

Michels, Nathalie; Aart, Carola van; Morisse, Jens; Mullee, Amy; Huybrechts, Inge

doi:10.1016/j.critrevonc.2020.103177

Cited by 77 publications

(65 citation statements)

References 131 publications

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“…Moreover, metabolic syndrome might increase the risk of disease recurrence and cancerspecific mortality in patients treated with radical prostatectomy [42,43]. Chronic inflammation, as measured by selected blood parameters, has been hypothesized as a potential link between metabolic disorders and PCa risk and progression, where a recent meta-analysis demonstrated an association between inflammatory markers and the risk of PCa [44]. When looking at metabolic syndrome components, a meta-analysis of 21 studies reported a signif- [46] Meta-analysis 1 418 407 The use of calcium channel blockers was associated with PCa incidence No association was found between total fat intake (RR: 0.99, 95% CI: 0.98-1.01), saturated fat (RR: 1.00, 95% CI: 1.00-1.00), polyunsaturated…”

Section: Metabolic Diseasesmentioning

confidence: 99%

Epidemiology and Prevention of Prostate Cancer

Gandaglia

Leni

Bray

et al. 2021

European Urology Oncology

313

131

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Context: Worldwide, prostate cancer (PCa) represents the second most common solid tumor in men. Objective: To assess the geographical distribution of PCa, epidemiological differences, and the most relevant risk factors for the disease. Evidence acquisition: Estimated incidence, mortality, and prevalence of PCa for the year 2020 in 185 countries were derived from the IARC GLOBOCAN database. A review of English-language articles published between 2010 and 2020 was conducted using MEDLINE, EMBASE, and Scopus to identify risk factors for PCa. Evidence synthesis: In the year 2020, there were over 1 414 000 estimated new cases of PCa worldwide, with an age-standardized rate (ASR) incidence of 31 per 100 000 (lifetime cumulative risk: 3.9%). Northern Europe has the highest all-age incidence ASR (83), while the lowest ASR was in South-Central Asia (6.3). In the year 2020, there were over 375 000 estimated deaths worldwide, and the overall mortality ASR was 7.7 per 100 000, with the highest ASR in the Caribbean (28) and the lowest in South-Central Asia (3.1). Family history, hereditary syndromes, and race are the strongest risk factors for PCa. Metabolic syndrome was associated with the risk of developing PCa, high-grade disease, and adverse pathology. Diabetes and exposure to ultraviolet rays were found to be inversely associated to PCa incidence. Cigarette smoking and obesity may increase PCa-specific mortality, while regular physical activity may reduce disease progression. Although 5-alpha reductase inhibitors are known to be associated with a reduced incidence of PCa, available studies failed to show an effect on overall mortality. Conclusions: Family history, race, and hereditary syndromes are well-established risk factors for PCa. Modifiable risk factors may impact the risk of developing PCa and that of dying from the disease, but little evidence exist for any clear indication for prevention other than early diagnosis to reduce PCa mortality. Patient summary: Prostate cancer (PCa) rates vary profoundly worldwide, with incidence and mortality rates being highest in Northern Europe and Caribbean, respectively. South-Central Asia has the lowest epidemiological burden. Family history, race, and hereditary syndromes are well-established risk factors for PCa. Modifiable risk factors

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Section: Metabolic Diseasesmentioning

confidence: 99%

Epidemiology and Prevention of Prostate Cancer

Gandaglia

Leni

Bray

et al. 2021

European Urology Oncology

313

131

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“…The comorbidities with the strongest independent effects on depression risk in the current study (Figure 2) included multiple conditions associated with chronic inflammation, suggesting it could be one of the principal mechanisms. A chronic state of inflammation has been implicated in the pathogenesis of depression [40][41][42], multiple types of cancer including breast, colorectal, lung, ovarian, and prostate cancer [43], and the chronic conditions that most frequently co-exist in cancer patients (i.e., cardiovascular conditions, obesity, metabolic, and autoimmune disorders) [44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007–2018

Petrova

Catena

Rodríguez‐Barranco

et al. 2021

Cancers

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Many adult cancer patients present one or more physical comorbidities. Besides interfering with treatment and prognosis, physical comorbidities could also increase the already heightened psychological risk of cancer patients. To test this possibility, we investigated the relationship between physical comorbidities with depression symptoms in a sample of 2073 adult cancer survivors drawn from the nationally representative National Health and Nutrition Examination Survey (NHANES) (2007–2018) in the U.S. Based on information regarding 16 chronic conditions, the number of comorbidities diagnosed before and after the cancer diagnosis was calculated. The number of comorbidities present at the moment of cancer diagnosis was significantly related to depression risk in recent but not in long-term survivors. Recent survivors who suffered multimorbidity had 3.48 (95% CI 1.26–9.55) times the odds of reporting significant depressive symptoms up to 5 years after the cancer diagnosis. The effect of comorbidities was strongest among survivors of breast cancer. The comorbidities with strongest influence on depression risk were stroke, kidney disease, hypertension, obesity, asthma, and arthritis. Information about comorbidities is usually readily available and could be useful in streamlining depression screening or targeting prevention efforts in cancer patients and survivors. A multidimensional model of the interaction between cancer and other physical comorbidities on mental health is proposed.

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“…These findings support the notion that inflammaging, the chronic, low-grade inflammation that develops with age, is a common process of normal lung aging and may contribute to susceptibility to age-related pathologies [ 24 ], including DNA lesion-induced carcinogenesis [ 25 ]. Actually, a recent published systematic review and meta-analysis provides epidemiological data on the relationship between chronic inflammation and cancer incidence including lung cancer [ 26 ]. Interestingly, IPA analysis performed in our data showed “Invasion of tumor” as one of the pathways affected by aging; some of the dysregulated genes were AREG, BIRC5, CCL2, CD14, CTSB, FN1, HMOX1, IL6, MMP14, MMP3, PLAU, S100A8, SERPINE1, SPP1, THBS1, VCAN .…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways

Calyeca

Balderas-Martínez

Selman

et al. 2021

Aging

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Aging is a universal biological process characterized by a progressive deterioration in functional capacity and an increased risk of morbidity and mortality over time. In the lungs, there are considerable changes in lung structure and function with advancing age; however, research on the transcriptomic profile implicated in this process is scanty. In this study, we addressed the lung transcriptome changes during aging, through a global gene expression analysis of normal lungs of mice aged 4- and 18-months old. Functional pathway enrichment analysis by Ingenuity Pathway Analysis (IPA) revealed that the most enriched signaling pathways in aged mice lungs are involved in the regulation of cell apoptosis, senescence, development, oxidative stress, and inflammation. We also found 25 miRNAs significantly different in the lungs of old mice compared with their younger littermates, eight of them upregulated and 17 downregulated. Using the miRNet database we identified TNFα, mTOR, TGFβ, WNT, FoxO, Apoptosis, Cell cycle, and p53 signaling pathways as the potential targets of several of the dysregulated miRNAs supporting that old lungs have increased susceptibility for apoptosis, inflammation, and fibrosis. These findings reveal differential expression profiles of genes and miRNAs affecting cell survival and the inflammatory response during lung aging.

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Chronic inflammation towards cancer incidence: A systematic review and meta-analysis of epidemiological studies

Cited by 77 publications

References 131 publications

Epidemiology and Prevention of Prostate Cancer

Epidemiology and Prevention of Prostate Cancer

Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007–2018

Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways

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