Chronic inflammatory and non-inflammatory diseases of the gastrointestinal tract in cats: Diagnostic advantages of full-thickness intestinal and extraintestinal biopsies

Abstract

An evaluation of histological findings in full-thickness biopsies from the gastrointestinal tract (GIT) and extraintestinal samples of 43 cats with chronic GIT disease signs was performed. In the majority of cases (46.5%) inflammatory bowel disease, ie, lymphocytic-plasmacytic enteritis/colitis (32.6%), eosinophilic gastroenterocolitis (11.6%) and mixed inflammatory infiltration (2.3%), was diagnosed. Furthermore, in four animals non-inflammatory mucosal band-shaped fibrosis (9.3%), and in 10 cats (23.3%) a diffuse lymphoma, was found. Six cats displayed only a gastritis (7.0%) or lymphangiectasia (7.0%), respectively. In two cats a mast cell tumour (4.7%) was diagnosed. In one cat no histopathological lesions were found. The availability of transmural biopsies from all segments of the intestine and the collection of extraintestinal samples, especially mesenteric lymph nodes, is especially helpful for diagnosing intestinal tumours such as lymphomas and tumours of mast cell origin.

Ability of ultrasonography to predict the presence and location of histologic lesions in the small intestine of cats

“…Specifically, differentiating between inflammatory bowel disease (IBD) and small‐cell lymphosarcoma/alimentary lymphoma (SC‐LSA) can be difficult. These 2 SI diseases can be identical in history, presentation, physical examination findings, clinicopathologic changes, and ultrasonographic findings . Small intestinal histopathology is the gold standard for diagnosing and differentiating these 2 disease entities.…”

“…A debate has emerged within the field of veterinary gastroenterology in recent years over how to obtain diagnostic biopsy specimens from the feline SI, by endoscopy or full thickness surgical biopsy. Many recent studies have brought the diagnostic utility of endoscopic biopsy into question and shown high variation among histologic diagnoses in different segments of SI . The previous studies, however, have failed to consider the biopsy collection methodology used for each individual case.…”

Concurrent Disease Management

“…57,97,125,135,252 In severely affected cats, this infiltrate may be accompanied by changes in the mucosal architecture, including villus atrophy and fusion, fibrosis, and lymphangiectasia. 57,97,125,135,252 In severely affected cats, this infiltrate may be accompanied by changes in the mucosal architecture, including villus atrophy and fusion, fibrosis, and lymphangiectasia.…”

Estudo retrospectivo da casuística em gatos domésticos (Felis catus, Lineu, 1758) do Serviço de Patologia Animal do Departamento de Patologia da FMVZ/USP entre 1998-2008

“…A coloração bicolor foi a mais frequente (18%), seguida pela coloração característica (16,1%), típica de gatos siameses, e os da coloração preta (10,6%). Este dado seria importante no caso de mortes provocadas por ações maliciosas, que muitas vezes são motivadas por preconceitos ou crenças, como a relação do gato preto com o azar e a utilização deste em rituais de magia negra, embora no presente estudo não haja evidências da influência deste parâmetro na mortalidade (LOCKWOOD, 2005 agentes tóxicos e deletérios, como cumarínicos e pó de vidro (FRAZIER et al, 1999;MOTAS-GUZMÁN et al, 2003;FORRESTER;STANLEY, 2004;GWALTNEY-BRANT, 2007;XAVIER, 2008;MARLET;MAIORKA, 2010 (JERGENS, 2002;RECHE JUNIOR, 2003;GELBERG, 2007;KLEINSCHMIDT et al, 2010).…”

“…No presente estudo foram avaliados os casos de adenocarcinoma palpebral, glândula ceruminosa e nasal, sendo que o primeiro apresenta frequência baixa tanto na literatura quanto no presente estudo e os dois últimos apresentam maior frequência na literatura. No caso de adenocarcinomas pulmonares de origem bronquial, estas são as neoplasias pulmonares primárias mais frequentes do pulmão, contudo são raras, embora no presente estudo foi encontra a mesma frequência de adenocarcinomas e carcinomas pulmonares (broncogênico) (HAYES; MILNE; MANDELL, 1981, TOMLINSON et al, 1984CRIBB, 1988;LONDON et al, 1996;MOISAN;WATSON, 1996;MCENTEE, 1997;MUKARATIRWA;GRUYS, 2001;HOFFMAN et al, 2005;LANGLAIS et al, 2006).…”