Chronic inflammatory demyelinating polyneuropathy triggered by interferon‐α for chronic hepatitis B virus infection

Abstract

Interferon-a has been widely used for treatment of chronic hepatitis and some malignancies. Several autoimmune diseases have been reported to be induced by interferon-a, but chronic inflammatory demyelinating polyneuropathy is rare. Here, we report a chronic hepatitis B patient who developed chronic inflammatory demyelinating polyneuropathy after receiving interferon-a treatment. After withdrawal of interferon-a, neurological symptoms continued to progress, but the symptoms improved after intravenous immunoglobulin treatment. This case provides further immunological insight into the correlation between chronic inflammatory demyelinating polyneuropathy and interferon-a.