Chronic insulin resistance

Field, James B.

doi:10.1007/bf01556784

Cited by 7 publications

(2 citation statements)

References 54 publications

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“…Weight gain in T2DM has been documented with insulin use [6] and become greater than those managed with other therapies [7]. Obesity is associated with decreased responsiveness to insulin in muscle, liver and fat [8] and weight gain of insulin therapy need more insulin and a potentially greater weight gain. Elevated concentration of insulin can cause insulin resistance by down regulating insulin receptors and desensitizing post receptor pathways [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of metformin and Pioglitazone on insulin dose reduction in type 2 diabetes mellitus patients: An open level comparative prospective study

Mazumdar¹,

Swaika²,

Dasgupta³

2012

JDM

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Insulin therapy cause weight gain and may increase its own requirement. Type 2 diabetes mellitus is associated with insulin resistance and affect both endogenous and exogenous insulin effect. Metformin and Pioglitazone, commonly used insulin sensitizers, have the potentiality of reducing the insulin dose, in Type-2 diabetes mellitus (T2DM) patients. This study was held to assess and compare such potentiality. 40 T2DM patients not controlled by diet, exercise and oral antidiabetic agents were selected for this study. Study had observed that Pioglitazone and metformin both significantly had reduced the dose of insulin. But metformin reduce the dose of insulin significantly more than that of Pioglitazone. Metformin had reduced the triglyceride, LDL-c, waist hip ratio significantly but modestly increased serum lactic acid and HDL-c. It can be concluded that co-administration of metformin with insulin is more beneficial in relation to the dose of insulin, waist hip ratio, and lipid modification when compare to Pioglitazone

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Section: Introductionmentioning

confidence: 99%

Effect of metformin and Pioglitazone on insulin dose reduction in type 2 diabetes mellitus patients: An open level comparative prospective study

Mazumdar¹,

Swaika²,

Dasgupta³

2012

JDM

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“…Since insulin treatment started in 1922 several side effects have been described repeatedly. These are insulin allergy [23], lipodystrophy [25] and insulin antibody formation with or without the development of insulin resistance [15].…”

mentioning

confidence: 99%

The clinical significance of highly purified pig-insulin preparations

Deckert¹,

Oo²,

Je³

1974

Diabetologia

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Side effects of insulin treatment (red spots at the injection site, lipoatrophy and insulin antibody formation) are primary related to the purity and the species of the insulin preparations used in treatment. To evaluate the clinical significance of these factors daily insulin requirements were registered in 1685 protamine insulin treated eases; red spots and lip| recorded in 500 NPI-I insulin treated patients and insulin antibodies determined in 173 patients. 51 of the patients were treated for more than 12 months with highly purified porcine insulin (proinsulin contamination <0.5 ram|174 96 patients were treated for 1-4 years with porcine NPH insulin (proinsulin contamination 12-13 ram|174 and most of the remaining patients have been treated with mixed porcine-bovine insulin preparations in earlier periods. It was shown that high purification of porcine NPH insulin is of importance in reducing insulin dose, lip| and insulin binding capacity of serum. Thus insulin antibodies could be demonstrated in only 3 of 51 patients after 1 ~ year of treatment with highly purified porcine NPI4 insulin. None of these patients developed red spots at the injection si~e and only one patient developed a small shallow depression of the subcutaneous tissue on one thigh. The daily insulin requirement was significantly lower when compared with the insulin requirement of a porcine NPI-I insulin treated control group.

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Diabetes und Stress-Situationen (Operationen, Infektionen, sonstige Stress-Situationen)

Petrides¹,

Napp-Mellinghoff²

1977

Diabetes Mellitus • B

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Chronic insulin resistance

Cited by 7 publications

References 54 publications

Effect of metformin and Pioglitazone on insulin dose reduction in type 2 diabetes mellitus patients: An open level comparative prospective study

Effect of metformin and Pioglitazone on insulin dose reduction in type 2 diabetes mellitus patients: An open level comparative prospective study

The clinical significance of highly purified pig-insulin preparations

Diabetes und Stress-Situationen (Operationen, Infektionen, sonstige Stress-Situationen)

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