Chronic intermittent hypobaric hypoxia ameliorates diabetic nephropathy through enhancing HIF1 signaling in rats

Tian, Yanming; Guan, Yue; Li, Na; Ma, Huijie; Zhang, Li; Wang, Sheng; Zhang, Yi

doi:10.1016/j.diabres.2016.06.021

Cited by 30 publications

(28 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tian et al identified an improvement in the mechanism of antioxidation and inhibition of TGF‐β1 signalling in diabetic rats, drawing a connection between this and the mechanisms of reactive O 2 species (ROS) that are aggravated by this pathology and linking the action of TGF‐β. In conclusion, all these processes were associated with kidney lesions and worsening diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 93%

“…There are some divergences in literature on the relationship between HIF and other genes involved on the installation of renal dysfunction. VEGF, GLUT1, and TGF‐β1 have been described as coexpressed genes under renal failure conditions; according to these studies, these markers may interact directly with the expression of HIF …”

Section: Discussionmentioning

confidence: 97%

“…Flisinski et al observed that HIF‐1α has a secondary response to CKD, ie, dysregulation of HIF‐1α and HIF‐2α is unrelated to the duration of CKD, but to the types of pathways used by muscle fibres (glycolytic or oxidative), physical activities performed or muscle function, blood supply of different muscles, and accumulation of uremic toxins (Homocysteine, Indoxyl Sulphate and ROS), Tian et al also found a connection between HIF and ROS.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, HIF-1α regulates the activity of AMPK and contributes to the improvement of kidney function, which corroborates the study of Chen et al 68 Using the small interference RNA technique (SiRNA) for the HIF-1α gene, Chen et al 68 studies, these markers may interact directly with the expression of HIF. 52,68,69,74,76 Baumann et al 77 reported, in an animal experiment, that increased HIF-1α expression potentiates the damage caused by specific TGF-βmediated kidney diseases and found a strong correlation between the COL1A2 gene-regulating HIF-1α in response to TGF-β.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

See 3 more Smart Citations

Role of hypoxia‐inducible factor 1α as a potential biomarker for renal diseases—A systematic review

Encinas

Foncesca

Perez

et al. 2019

Cell Biochemistry & Function

View full text Add to dashboard Cite

Renal cells need oxygen for homeostasis; it is known for adjusting cellular functioning and the energy obtainment have a broad relationship with cellular respiration, through the O2 bioavailability. O2 homeostasis regulation in the kidney is mediated by hypoxia‐inducible factors (HIFs). HIF is divided into three α isoforms, represented by HIF‐1α, HIF‐2α, and HIF‐3α in addition to three paralogs of HIF‐1β; these are involved in some metabolic processes, as well as in the pathogenesis of several diseases. Renal biopsy analyses of patients and experimental animal models aim to understand the relationship between HIF and protection against developing renal diseases or the induction of their onset, being thus this molecule can be considered a potential biomarker of renal disease. We carried out a systematic review to which we included studies on HIF‐1α and renal disease in the last 5 years (2013‐2018) in researches with humans and/or animal model through searches in three databases: LILACS, PubMed, and SciELO by two researchers. We obtained 22 articles that discussed the relationship with HIF as inductor or protector against renal disease and no relation between HIF and renal. We observed controversies remain regarding the relation between of HIF with renal diseases; this may be related to the different intracellular pathways mediated by HIF‐1α, thereby determining differentiated cellular responses.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

See 2 more Smart Citations

Role of hypoxia‐inducible factor 1α as a potential biomarker for renal diseases—A systematic review

Encinas

Foncesca

Perez

et al. 2019

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…Chronic intermittent hypobaric hypoxia (CIHH) simulates the plateau environment via low-pressure and low-oxygen conditions. Previous studies have shown that CIHH have beneficial effects on various tissues of the body (Cui et al, 2018;Shi et al, 2015;Tian et al, 2016;Yuan et al, 2015;Zhou et al, 2013), including improving ischemia/reperfusion or hypoxia/reoxygenation induced tissues damage (Zhou et al, 2013); improving endothelial dysfunction and vascular relaxation in mesenteric arteries (Cui et al, 2018); anti-inflammatory effect by reducing the level of collagen-induced arthritis inflammatory factors (Shi et al, 2015); improving fructose induced liver damage by inhibiting ERS (Yuan et al, 2015). However, the effect and mechanisms of autophagy on CIHH inhibiting ERS in the liver of rats, is still unclear.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Autophagy on Chronic Intermittent Hypobaric Hypoxia Ameliorating Liver Damage in Metabolic Syndrome Rats

Cui

Guo

et al. 2020

Front. Physiol.

View full text Add to dashboard Cite

Aim: Our previous study demonstrated that chronic intermittent hypobaric hypoxia (CIHH) can confer hepatic protection by reducing endoplasmic reticulum stress (ERS) in high-fat-high-fructose induced metabolic syndrome (MS) rats. It is known that there is a functional coupling between autophagy and ERS. This study aimed to investigate the effect of CIHH on autophagy function and adenosine mono-phosphate-activated protein kinase-mammalian target of rapamycin (AMPKα-mTOR) signaling pathway in hepatic tissue of MS rats.Main Methods: 6-week old male Sprague-Dawley rats were randomly divided into: control (CON), CIHH (treated with hypobaric hypoxia simulating 5000-m altitude for 28 days, 6 h daily), MS (induced by 16-week high fat diet and 10% fructose water feeding), and MS + CIHH groups (exposed to CIHH after 16-week MS model). Food and water intakes, body weight, Lee's index, fat coefficient, systolic arterial pressure, blood biochemicals, and histopathology of liver were measured, the expression of phosphorylated (p)-AMPK, p-mTOR, autophagy-related and ERS-related proteins were assayed in hepatic tissue.Key Findings: The MS rats displayed obesity, hypertension, polydipsia, glucose and lipids metabolism disorders, increased inflammatory cytokine, hepatic tissue morphological and functional damage, and the up-regulated expressions of ERSrelated, autophagy-related proteins and p-mTOR, and the down-regulated expression of p-AMPKα. All aforementioned abnormalities in MS rats were ameliorated in MS + CIHH rats.Significance: In conclusion CIHH confers hepatic protection through activating AMPK-mTOR signaling pathway and the autophagy function, thus inhibiting ERS in hepatic tissue.Keywords: chronic intermittent hypobaric hypoxia, metabolic syndrome, endoplasmic reticulum stress, autophagy, AMPK-mTOR signaling pathway Frontiers in Physiology | www.frontiersin.org January 2020 | Volume 11 | Article 13 absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

show abstract

Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats

Chang

et al. 2016

J of Cellular Biochemistry

View full text Add to dashboard Cite

Disruption of iron homeostasis in brain has been found to be closely involved in several neurodegenerative diseases. Recent studies have reported that appropriate intermittent hypobaric hypoxia played a protective role in brain injury caused by acute hypoxia. However, the mechanisms of this protective effect have not been fully understood. In this study, Sprague-Dawley (SD) rat models were developed by hypobaric hypoxia treatment in an altitude chamber, and the iron level and iron related protein levels were determined in rat brain after 4 weeks of treatment. We found that the iron levels significantly decreased in the cortex and hippocampus of rat brain as compared to that of the control rats without hypobaric hypoxia treatment. The expression levels of iron storage protein L-ferritin and iron transport proteins, including transferrin receptor-1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin1 (FPN1), were also altered. Further studies found that the iron regulatory protein 2 (IRP2) played a dominant regulatory role in the changes of iron hemostasis, whereas iron regulatory protein 1 (IRP1) mainly acted as cis-aconitase. These results, for the first time, showed the alteration of iron metabolism during hypobaric hypoxia in rat models, which link the potential neuroprotective role of hypobaric hypoxia treatment to the decreased iron level in brain. This may provide insight into the treatment of iron-overloaded neurodegenerative diseases. J. Cell. Biochem. 118: 1596-1605, 2017. © 2016 Wiley Periodicals, Inc.

show abstract

Chronic intermittent hypobaric hypoxia ameliorates diabetic nephropathy through enhancing HIF1 signaling in rats

Cited by 30 publications

References 43 publications

Role of hypoxia‐inducible factor 1α as a potential biomarker for renal diseases—A systematic review

Role of hypoxia‐inducible factor 1α as a potential biomarker for renal diseases—A systematic review

The Effect of Autophagy on Chronic Intermittent Hypobaric Hypoxia Ameliorating Liver Damage in Metabolic Syndrome Rats

Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats

Contact Info

Product

Resources

About