Chronic intermittent hypoxia worsens brain damage and sensorimotor behavioral abnormalities after ischemic stroke: Effect on autonomic nervous activity and sleep patterns

Lin, Chong; Li, Jia-Yi; Kuo, Terry B.J.; Huang, Changwei; Huang, Shiang‐Suo; Yang, Cheryl C.H.

doi:10.1016/j.brainres.2022.148159

Cited by 1 publication

(1 citation statement)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have suggested that OSA can lead to an adverse prognosis in cerebral infarction, impair brain function, exacerbate cognitive dysfunction, and increase mortality risk (30)(31)(32)(33). The main mechanisms underlying these adverse outcomes include chronic intermittent hypoxia, sympathetic activation, changes in cerebral blood flow, oxidative stress, systemic inflammation, hypercoagulability, and endothelial dysfunction (34,35). However, recent research has proposed the possibility of a causal relationship between OSA and stroke being non-existent.…”

Section: Discussionmentioning

confidence: 99%

Correlation between obstructive sleep apnea and hypoperfusion in patients with acute cerebral infarction

Zhou,

Jin,

Liu

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

PurposeTo explore the relationship between obstructive sleep apnea (OSA) and hypoperfusion during ultra-early acute cerebral infarction.Patients and methodsData were retrospectively collected from patients admitted to our hospital with acute cerebral infarction between January 2020 and January 2022, who underwent comprehensive whole-brain computed tomography perfusion imaging and angiography examinations within 6 h of onset. The F-stroke software automatically assessed and obtained relevant data (Tmax). The patients underwent an initial screening for sleep apnea. Based on their Apnea-Hypopnea Index (AHI), patients were categorized into an AHI ≤15 (n = 22) or AHI >15 (n = 25) group. The pairwise difference of the time-to-maximum of the residue function (Tmax) > 6 s volume was compared, and the correlation between AHI, mean pulse oxygen saturation (SpO2), oxygen desaturation index (ODI), percentage of time with oxygen saturation < 90% (T90%), and the Tmax >6 s volume was analyzed.ResultsThe Tmax >6 s volume in the AHI > 15 group was significantly larger than that in the AHI ≤ 15 group [109 (62–157) vs. 59 (21–106) mL, p = 0.013]. Spearman’s correlation analysis revealed Tmax >6 s volume was significantly correlated with AHI, mean SpO2, ODI, and T90% in the AHI > 15 group, however, no significant correlations were observed in the AHI ≤ 15 group. Controlling for the site of occlusion and Multiphase CT angiography (mCTA) score, AHI (β = 0.919, p < 0.001), mean SpO2 (β = −0.460, p = 0.031), ODI (β = 0.467, p = 0.032), and T90% (β =0.478, p = 0.026) remained associated with early hypoperfusion in the AHI > 15 group.ConclusionIn patients with acute cerebral infarction and AHI > 15, AHI, mean SpO2, ODI and T90% were associated with early hypoperfusion. However, no such relationship exists among patients with AHI ≤ 15.

show abstract