Chronic interstitial nephritis in agricultural communities: a new perspective on etiology, diagnosis and mechanism

Vervaet, Benjamin A.; Nast, Cynthia C.; Schreurs, Gerd; Jayasumana, Channa; Herath, Chula; Kojc, Nika; Broe, Marc E. De

doi:10.1016/j.nephro.2020.02.010

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Direct immunofluorescence did not reveal any significant deposits in the glomeruli or along the tubular basement membrane [61]. The presence of these lesions in biopsies from individuals with low or no proteinuria living in agricultural environments confirms the diagnosis of CTINAC and highlights the importance of performing biopsies for diagnostic, prognostic, and potential therapeutic purposes [62].…”

Section: Pathophysiology and Pathology Of Ctinacmentioning

confidence: 57%

“…Recently, in their article, Vervaet BA et al [62] stressed addressing new research avenues in order to progress on etiology, mechanism, treatment, prevention, and general awareness. In order to address this issue, continued research is very important and will need collaboration between researchers, the government, various farmer organizations, and the World Health Organisation.…”

Section: Recent Advances and Future Research In The Understanding Of ...mentioning

confidence: 99%

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Chronic Tubulointerstitial Nephropathy of Agricultural Communities

Sharma

Anandh

Gowrishankar

2023

Kidney and Dialysis

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Chronic interstitial nephritis in agricultural communities is an emerging public health concern affecting numerous agricultural communities in tropical countries, including regions in India, with a significant impact on the health and well-being of affected individuals. The affected individuals suffer from various psychosocial, nutritional, and metabolic challenges due to organ failure, which affects their quality of life. The etiology remains poorly understood, and various risk factors, which include various environmental and occupational hazards, have been implicated in its development. The recent discovery of lysosomal proximal tubulopathy has reignited interest in its pathogenesis. Along with the representative feature of chronic interstitial nephritis, changes suggestive of tubular injury have also been reported. It is suggested to use the term “chronic tubulointerstitial nephropathy of agricultural community” instead of chronic interstitial nephritis of the agricultural communities. Chronic tubulointerstitial nephropathy in agricultural communities is a slowly progressive disease that initially does not cause any symptoms in patients and most patients have a delayed onset of symptoms. Several diagnostic criteria have been introduced over the past years and one introduced by the Ministry of Health of Sri Lanka is widely used. The management of this chronic illness is no different from other causes of chronic interstitial nephritis and our focus should be on implementing various preventive strategies to reduce its incidence in agricultural communities and protect the health and well-being of agricultural workers. By disseminating knowledge about chronic tubulointerstitial nephropathy in agricultural communities, we can contribute to the development of evidence-based interventions to reduce the burden of the disease on affected communities. Moreover, we would like to sensitize physicians to this entity to increase awareness and identify potential endemic areas in various agricultural communities.

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Section: Pathophysiology and Pathology Of Ctinacmentioning

confidence: 57%

Section: Recent Advances and Future Research In The Understanding Of ...mentioning

confidence: 99%

Chronic Tubulointerstitial Nephropathy of Agricultural Communities

Sharma

Anandh

Gowrishankar

2023

Kidney and Dialysis

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“…Posteriormente, se propuso el término Nefritis Intersticial Crónica en Comunidades Agrícolas (CINAC) para describir ambas entidades. Para el presente artículo se utilizará (2) el término CINAC, con el cual nos referiremos a esta entidad nosológica .…”

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“…Llamativamente, estos pacientes no presentaban causas tradicionales de ERC como glomerulonefritis, nefropatía diabética o enfermedad poliquística e hipertensión arterial, esta última solo aparecía como un hallazgo tardío. La proteinuria era rara, pero cuando estaba presente, era menor de (2) 1 g o del tipo tubular . Por estas razones, a esta forma clínica de presentación se le denominó inicialmente ERC de causas no tradicionales por la ausencia de comorbilidades frecuentemente asociadas a la etiología del daño renal.…”

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A new challenge for doctors in Paraguay: chronic interstitial nephritis in agricultural communities (CINAC)

Jara

Romero

Gamarra

et al. 2022

Rev. virtual Soc. Parag. Med. Int

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Omics Studies in CKD: Diagnostic Opportunities and Therapeutic Potential

Rroji,

Spasovski

2024

Proteomics

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Omics technologies have significantly advanced the prediction and therapeutic approaches for chronic kidney disease (CKD) by providing comprehensive molecular insights. This is a review of the current state and future prospects of integrating biomarkers into the clinical practice for CKD, aiming to improve patient outcomes by targeted therapeutic interventions. In fact, the integration of genomic, transcriptomic, proteomic, and metabolomic data has enhanced our understanding of CKD pathogenesis and identified novel biomarkers for an early diagnosis and targeted treatment. Advanced computational methods and artificial intelligence (AI) have further refined multi‐omics data analysis, leading to more accurate prediction models for disease progression and therapeutic responses. These developments highlight the potential to improve CKD patient care with a precise and individualized treatment plan .

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Chronic interstitial nephritis in agricultural communities: a new perspective on etiology, diagnosis and mechanism

Cited by 5 publications

References 29 publications

Chronic Tubulointerstitial Nephropathy of Agricultural Communities

Chronic Tubulointerstitial Nephropathy of Agricultural Communities

A new challenge for doctors in Paraguay: chronic interstitial nephritis in agricultural communities (CINAC)

Omics Studies in CKD: Diagnostic Opportunities and Therapeutic Potential

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