Chronic intestinal ischemia and splanchnic blood-flow: Reference values and correlation with body-composition

Henriksen, Jens H.; Abrahamsen, Jan

doi:10.3748/wjg.v19.i6.882

Cited by 12 publications

(15 citation statements)

References 22 publications

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“…Catheterization in this group was performed on suspicion of intestinal ischaemia with the measurement of splanchnic oxygen uptake during a meal stimulation test [23], but was ruled out during the haemodynamic investigation.…”

Section: Study Populationmentioning

confidence: 99%

“…As a control group served 15 patients (seven men and eight women) without signs of liver disease and liver enzymes within the normal range at the time of investigation. Catheterization in this group was performed on suspicion of intestinal ischaemia with the measurement of splanchnic oxygen uptake during a meal stimulation test [23], but was ruled out during the haemodynamic investigation.…”

Section: Study Populationmentioning

confidence: 99%

See 1 more Smart Citation

New vasoactive peptides in cirrhosis: organ extraction and relation to the vasodilatory state

Kimer

Goetze

Bendtsen

et al. 2014

Eur J Clin Investigation

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Background Patients with cirrhosis have substantial circulatory imbalance between vasoconstrictive and vasodilating forces. The study of circulatory vasoactive peptides may provide important pathophysiological information. This study aimed to assess concentrations, organ extraction and relations to haemodynamic changes in the pro-peptides copeptin, proadrenomedullin and pro-atrial natriuretic peptide (proANP) in patients with cirrhosis.

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Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

New vasoactive peptides in cirrhosis: organ extraction and relation to the vasodilatory state

Kimer

Goetze

Bendtsen

et al. 2014

Eur J Clin Investigation

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show abstract

“…Splanchnic oxygen consumption has been observed in normal humans to increase in the first hour following a mixed meal by over 50%[29147272] and postprandial O 2 consumption by the gastric mucosa during secretory periods, along with the thick gastric muscle requirement for O 2 during contraction, contribute significantly to lowering portal O 2 following a meal. [37128165184] Hepatic oxygen delivery is further compromised following a meal by increased hepatic artery resistance leading to lower arterial flow.…”

Section: Hepatic Oxygen Deliverymentioning

confidence: 99%

Metabolic syndrome and the hepatorenal reflex

Wider¹

2016

Surg Neurol Int

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Insufficient hepatic O2 in animal and human studies has been shown to elicit a hepatorenal reflex in response to increased hepatic adenosine, resulting in the stimulation of renal as well as muscle sympathetic nerve activity and activating the renin angiotensin system. Low hepatic ATP, hyperuricemia, and hepatic lipid accumulation reported in metabolic syndrome (MetS) patients may reflect insufficient hepatic O2 delivery, potentially accounting for the sympathetic overdrive associated with MetS. This theoretical concept is supported by experimental results in animals fed a high fructose diet to induce MetS. Hepatic fructose metabolism rapidly consumes ATP resulting in increased adenosine production and hyperuricemia as well as elevated renin release and sympathetic activity. This review makes the case for the hepatorenal reflex causing sympathetic overdrive and metabolic syndrome in response to exaggerated splanchnic oxygen consumption from excessive eating. This is strongly reinforced by the fact that MetS is cured in a matter of days in a significant percentage of patients by diet, bariatric surgery, or endoluminal sleeve, all of which would decrease splanchnic oxygen demand by limiting nutrient contact with the mucosa and reducing the nutrient load due to loss of appetite or dietary restriction.

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“…Portal blood flow to the liver increases over 100% following a meal[ 236 237 238 239 240 241 242 243 244 245 ] depending on the type of nutrient,[ 239 246 247 248 249 ] but the portal hemoglobin saturation can be very low due to increased oxygen demand from gut secretory and contractile activity. Splanchnic oxygen consumption has been observed in normal humans to increase in the first hour following a mixed meal by over 50%[ 270 271 272 ] and postprandial O 2 consumption by the gastric mucosa during secretory periods, along with the thick gastric muscle requirement for O 2 during contraction, contribute significantly to lowering portal O 2 following a meal. [ 273 274 275 276 ] Hepatic oxygen delivery is further compromised following a meal by increased hepatic artery resistance leading to lower arterial flow.…”

Section: Hepatic Oxygen Deliverymentioning

confidence: 99%

Metabolic syndrome and the hepatorenal reflex

Wider

2016

Surg Neurol Int

View full text Add to dashboard Cite

Insufficient hepatic O2 in animal and human studies has been shown to elicit a hepatorenal reflex in response to increased hepatic adenosine, resulting in stimulation of renal as well as muscle sympathetic nerve activity and activating the renin angiotensin system. Low hepatic ATP, hyperuricemia, and hepatic lipid accumulation reported in metabolic syndrome (MetS) patients may reflect insufficient hepatic O2 delivery, potentially accounting for the sympathetic overdrive associated with MetS. This theoretical concept is supported by experimental results in animals fed a high fructose diet to induce MetS. Hepatic fructose metabolism rapidly consumes ATP resulting in increased adenosine production and hyperuricemia as well as elevated renin release and sympathetic activity. This review makes the case for the hepatorenal reflex causing sympathetic overdrive and metabolic syndrome in response to exaggerated splanchnic oxygen consumption from excessive eating. This is strongly reinforced by the fact that MetS is cured in a matter of days in a significant percentage of patients by diet, bariatric surgery, or endoluminal sleeve, all of which would decrease splanchnic oxygen demand by limiting nutrient contact with the mucosa and reducing the nutrient load due to the loss of appetite or dietary restriction.

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Chronic intestinal ischemia and splanchnic blood-flow: Reference values and correlation with body-composition

Abstract: A direct correlation between body weight and the postprandial increase in SBF was observed. The effect of body weight should be considered in the diagnosis of chronic intestinal ischemia.

Cited by 12 publications

References 22 publications

New vasoactive peptides in cirrhosis: organ extraction and relation to the vasodilatory state

New vasoactive peptides in cirrhosis: organ extraction and relation to the vasodilatory state

Metabolic syndrome and the hepatorenal reflex

Metabolic syndrome and the hepatorenal reflex

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