Chronic Intracortical Recording and Electrochemical Stability of Thiol-ene/Acrylate Shape Memory Polymer Electrode Arrays

Stiller, Allison M.; Usoro, Joshua O.; Frewin, Christopher L.; Danda, Vindhya; Ecker, Melanie; Joshi‐Imre, Alexandra; Musselman, Kate C.; Voit, Walter; Modi, Romil; Pancrazio, Joseph J.; Black, Bryan

doi:10.3390/mi9100500

Cited by 51 publications

(56 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the past decade, there has been a renewed interest in the use of thin films and other “soft” electrode materials to create high‐channel, yet low geometric area electrodes with a Young's modulus closer to native tissue to minimize initial surgical trauma and the chronic immune response . These electrode development strategies include the use of PDMS substrates with conductive traces and electrode contacts to develop stretchable multicontact electrode arrays for stimulation and recording .…”

Section: Resultsmentioning

confidence: 99%

“…These electrode development strategies include the use of PDMS substrates with conductive traces and electrode contacts to develop stretchable multicontact electrode arrays for stimulation and recording . Additionally, shape memory polymer (SMP) or other “shuttles” have been used to create a stiff carrier to facilitate implantation of electrodes into the brain, yet leave a soft electrode chronically to minimize the immune response of tissue . Similarly, the Charles Lieber group has demonstrated that a ultraflexible open mesh electrode array can be injected into the rodent brain via syringe and minimize the chronic immune response, enabling high‐quality chronic recordings for periods of at least 12 weeks .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

An Injectable Neural Stimulation Electrode Made from an In‐Body Curing Polymer/Metal Composite

Trevathan

Baumgart

Nicolai

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

Implanted neural stimulation and recording devices hold vast potential to treat a variety of neurological conditions, but the invasiveness, complexity, and cost of the implantation procedure greatly reduce access to an otherwise promising therapeutic approach. To address this need, a novel electrode that begins as an uncured, flowable prepolymer that can be injected around a neuroanatomical target to minimize surgical manipulation is developed. Referred to as the Injectrode, the electrode conforms to target structures forming an electrically conductive interface which is orders of magnitude less stiff than conventional neuromodulation electrodes. To validate the Injectrode, detailed electrochemical and microscopy characterization of its material properties is performed and the feasibility of using it to stimulate the nervous system electrically in rats and swine is validated. The silicone-metal-particle composite performs very similarly to pure wire of the same metal (silver) in all measures, including exhibiting a favorable cathodic charge storage capacity (CSC C ) and charge injection limits compared to the clinical LivaNova stimulation electrode and silver wire electrodes. By virtue of its simplicity, the Injectrode has the potential to be less invasive, more robust, and more cost-effective than traditional electrode designs, which could increase the adoption of neuromodulation therapies for existing and new indications.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

An Injectable Neural Stimulation Electrode Made from an In‐Body Curing Polymer/Metal Composite

Trevathan

Baumgart

Nicolai

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…In previous works, the Voit Lab has presented in vitro and in vivo biocompatibility test results assessing cytotoxicity and neurotoxicity of the substrate SMP material 19,22–24 . Cytotoxcity tests using NCTC fibroblasts and primary cortical neurons 24 , and neurotoxicity tests using MEA-based functional assays 19,24 and in vitro glial scarring assays 24 were carried out.…”

Section: Introductionmentioning

confidence: 99%

A softening laminar electrode for recording single unit activity from the rat hippocampus

Zátonyi

Orbán

Modi

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Softening neural implants that change their elastic modulus under physiological conditions are promising candidates to mitigate neuroinflammatory response due to the reduced mechanical mismatch between the artificial interface and the brain tissue. Intracortical neural probes have been used to demonstrate the viability of this material engineering approach. In our paper, we present a robust technology of softening neural microelectrode and demonstrate its recording performance in the hippocampus of rat subjects. The 5 mm long, single shank, multi-channel probes are composed of a custom thiol-ene/acrylate thermoset polymer substrate, and were micromachined by standard MEMS processes. A special packaging technique is also developed, which guarantees the stable functionality and longevity of the device, which were tested under in vitro conditions prior to animal studies. The 60 micron thick device was successfully implanted to 4.5 mm deep in the hippocampus without the aid of any insertion shuttle. Spike amplitudes of 84 µV peak-to-peak and signal-to-noise ratio of 6.24 were achieved in acute experiments. Our study demonstrates that softening neural probes may be used to investigate deep layers of the rat brain.

show abstract

“…Comparison among different strategies of stimulation of PNS to evoke tactile percepts. Parameters that have been considered are: i) number of subjects (S) and implant duration; ii) type of implanted electrode, number of channels, nerve target; iii) impedance measurement; iv) type of stimulation pattern; v) threshold charge/current over time; vi) …”

Section: Implantable Neuroprostheses In Clinical Applicationsmentioning

confidence: 99%

“…Plexon offers solutions data acquisition and stimulation systems but also electrodes for research needs for cortical recordings (channel counts up to 32 with platinum–iridium contacts) …”

Section: Future Of Neuroprostheticsmentioning

confidence: 99%

Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems

Cutrone

Micera

2019

Adv Healthcare Materials

View full text Add to dashboard Cite

functions of nervous system when damages occur. Moreover, in case of physical impairments, the use of artificial tactile sensors is also paramount to ensure the possibility to restore the sense of touch to the patient. Bioinspiration from human natural touch could help in the release of enhanced tactile sensors to be used in neuroprosthetics. Technological and biological advancements brought serious improvements in the quality of these devices, such as miniaturization and increased biocompatibility. This article reviews the essential design criteria, working principles, materials, and technical considerations on neural interfaces and tactile sensors; their clinical application in neuroprosthetics and their future progress toward optimized solutions. Neural InterfacesA neural interface device (NID) is an implantable tool that aims at restoring nervous system functions in case of impairments or communicates with external components (e.g., limb prostheses); its main objective is to record neural signal from a small group of axons/cells or to stimulate a selected area of the nervous system. The clinical potentialities of NIDs range from their applications in central nervous system (CNS) for treating epilepsy seizures, mitigating Parkinson's disease; in peripheral nervous system (PNS) for controlling limb prostheses in amputees and restore sensory feedback; in autonomous nervous system such as vagus nerve to treat drug-resistant epilepsy and chronic depression to finally auditory and vision systems to restore the perception of specific sounds and phosphenes. An ideal NID should be biocompatible, highly selective, low invasive and stable over long time. If intended for clinical applications, the functionality of a NID should be reliable and should last decades. Considering the different implantation sites of interest of the device, various solutions have been proposed to optimize the communication between the NID and the surrounding environment. Figure 1 highlights the main applications of most common used NIDs in neuroprosthetics. With a special focus on implantable neuroprostheses and motor system, this paragraph will portray the design criteria, the materials and technical considerations heretofore used for the development of diverse types of NID used in CNS and PNS.Neuroprosthetics and neuromodulation represent a promising field for several related applications in the central and peripheral nervous system, such as the treatment of neurological disorders, the control of external robotic devices, and the restoration of lost tactile functions. These actions are allowed by the neural interface, a miniaturized implantable device that most commonly exploits electrical energy to fulfill these operations. A neural interface must be biocompatible, stable over time, low invasive, and highly selective; the challenge is to develop a safe, compact, and reliable tool for clinical applications. In case of anatomical impairments, neuroprosthetics is bound to the need of exploring the surrounding environment by fast-responsive and ...

show abstract

Chronic Intracortical Recording and Electrochemical Stability of Thiol-ene/Acrylate Shape Memory Polymer Electrode Arrays

Cited by 51 publications

References 50 publications

An Injectable Neural Stimulation Electrode Made from an In‐Body Curing Polymer/Metal Composite

An Injectable Neural Stimulation Electrode Made from an In‐Body Curing Polymer/Metal Composite

A softening laminar electrode for recording single unit activity from the rat hippocampus

Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems

Contact Info

Product

Resources

About