Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease

Yang, Jingang; Li, Jue; Lu, Chang; Hasimu, Buaijiaer; Yang, Yuejin; Hu, Dayi

doi:10.5551/jat.3061

Cited by 26 publications

(19 citation statements)

References 37 publications

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“…The importance of kidney disease as a risk factor for atherosclerotic disease is increasingly recognized 5,6) . Albuminuria has been shown to be linked to increased risks of cardiovascular disease, systemic atherosclerosis, and death not only in patients with diabetes or hypertension, but also in general populations 4,[7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Albuminuria as a Risk Factor for Peripheral Arterial Disease in a General Population

Usui

Ninomiya

Nagata

et al. 2011

JAT

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Aims: To elucidate the relationship between albuminuria and the prevalence of peripheral arterial disease (PAD), and to examine the effect of albuminuria on the ability to assess the likelihood of PAD in a general Japanese population.Methods: In 3,061 community-dwelling subjects aged ≥ 40 years, we investigated the association of urinary albumin-creatinine ratio (UACR) levels with the prevalence of PAD, defined as an anklebrachial index 0.9. The odds ratio for the presence of PAD was estimated using the logistic regression model. To compare the accuracy of the assessment for the likelihood of prevalent PAD between models adjusted for potential risk factors with and without UACR levels, the receiver operating characteristic (ROC) curves were plotted.Results: Overall, 1.47% of the study participants had PAD. The age-and sex-adjusted prevalence of PAD increased linearly for UACR levels of 5.6, 5.6-10.8, 10.9-29.9, 30.0-300.0, and 300.0 mg/g, being 0.34, 0.80, 2.02, 2.50, and 2.53%, respectively ( p for trend 0.001). The multivariateadjusted odds ratio for the presence of PAD was 1.85 (95% confidence interval 1.12-3.06) for every 10-fold increment in UACR. The area under the ROC curve significantly increased when UACR levels were incorporated into a model with potential risk factors for PAD (0.80 vs. 0.77, p 0.02).Conclusion: Greater UACR levels are associated linearly with a higher prevalence of PAD, even within the normoalbuminuric range, in the general Japanese population, and combining UACR levels with potential risk factors substantially improves the performance to assess the likelihood of PAD. J Atheroscler Thromb, 2011; 18:705-712.

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Section: Introductionmentioning

confidence: 99%

Albuminuria as a Risk Factor for Peripheral Arterial Disease in a General Population

Usui

Ninomiya

Nagata

et al. 2011

JAT

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“…One year after the onset of CLI, 25% patients have died and another 25% have had the limb amputated; amputation-free survival after one year is estimated to be as low as 50%. Despite such a poor prognosis of CLI patients, its prognostic risk factors remains to be elucidated, which is in contrast to other cardiovascular diseases, including PAD other than CLI [2][3][4][5][6] . Diabetes mellitus (DM), one of the major risk factors for other cardiovascular diseases, is prevalent among the CLI population and its presence has been believed to have some association with the prognosis of CLI.…”

Section: Introductionmentioning

confidence: 99%

No Association of Diabetic Duration or Insulin Use with the Prognosis of Critical Limb Ischemia after Endovascular Therapy

Takahara

Kaneto

Iida

et al. 2011

JAT

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“…Chronic kidney disease (CKD) has received considerable attention as an important risk factor for cardiovascular disorders, including ischemic heart disease, heart failure, cerebrovascular disease, and peripheral arterial disease, and all-cause mortality [1][2][3][4] . In addition, CKD patients are likely to develop end-stage kidney disease (ESKD), which can reduce their quality of life (QOL) and has become a socioeconomic concern.…”

Section: Introductionmentioning

confidence: 99%

Associations between Healthy Lifestyle Behaviors and Proteinuria and the Estimated Glomerular Filtration Rate (eGFR)

Fujibayashi

Fukuda

Yokokawa

et al. 2012

JAT

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Aim:The aim was to investigate the respective associations between lifestyle and proteinuria and the estimated glomerular filtration rate (eGFR). Methods: The lifestyle habits of 25,493 middle-aged participants were investigated in a cross-sectional study to find habits that are associated with a low eGFR (＜60 mL/min/1.73 m 2 ) and/or the presence of proteinuria. The lifestyle habits of the participants were evaluated using a questionnaire. Unhealthy lifestyle habits were defined as follows: 1. obesity, 2. being a current/former smoker, 3. eating irregular meals, 4. having less than 5 hours sleep, 5. exercising less than once a week, and 6. drinking more than once a week. The associations among unhealthy habits, eGFR, and proteinuria were evaluated using multivariate analysis.

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Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease

Cited by 26 publications

References 37 publications

Albuminuria as a Risk Factor for Peripheral Arterial Disease in a General Population

Albuminuria as a Risk Factor for Peripheral Arterial Disease in a General Population

No Association of Diabetic Duration or Insulin Use with the Prognosis of Critical Limb Ischemia after Endovascular Therapy

Associations between Healthy Lifestyle Behaviors and Proteinuria and the Estimated Glomerular Filtration Rate (eGFR)

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