2015
DOI: 10.1007/s00774-014-0639-x
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Chronic kidney disease and bone metabolism

Abstract: Chronic kidney disease-related mineral and bone disease (CKD-MBD) is a syndrome defined as a systemic mineral metabolic disorder associated with CKD, and the term renal osteodystrophy indicates a pathomorphological concept of bone lesions associated with CKD-MBD. Cortical bone thinning, abnormalities in bone turnover and primary/secondary mineralization, elevated levels of circulating sclerostin, increased apoptosis in osteoblasts and osteocytes, disturbance of the coupling phenomenon, iatrogenic factors, accu… Show more

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Cited by 43 publications
(22 citation statements)
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“…Thus, the fragility fractures in CKD patients do not seem to be mainly caused by CKD-MBD, but by an osteoporotic condition specifically caused by uremia. We have designated this disease condition "uremic osteoporosis" [47,48]. If the results of the present animal experiment are reproducible in humans, increased pentosidine-to-matrix ratio and decreased BAp orientation are likely candidates for the pathogenesis of uremic osteoporosis.…”
Section: Discussionmentioning
confidence: 91%
“…Thus, the fragility fractures in CKD patients do not seem to be mainly caused by CKD-MBD, but by an osteoporotic condition specifically caused by uremia. We have designated this disease condition "uremic osteoporosis" [47,48]. If the results of the present animal experiment are reproducible in humans, increased pentosidine-to-matrix ratio and decreased BAp orientation are likely candidates for the pathogenesis of uremic osteoporosis.…”
Section: Discussionmentioning
confidence: 91%
“…However, a controversy still remains on the relationship between parathyroid function and structure-related bone strength [29, 30]. One possible explanation for this issue is that extremely high plasma level of PTH is required to cause evident cortical thinning in dialysis patients [31], because skeletal resistance to PTH stimuli is increased in uremic condition [3234]. …”
Section: What Happens In Bone When Kidney Is Injured?mentioning
confidence: 99%
“…For comparison, patients with cancer who did not receive HSCT during the same period were randomly selected and matched with the study cohort at a 4:1 ratio by propensity score. The common comorbidities that could be associated with osteoporosis or fracture were included for analysis, namely diabetes mellitus (ICD-9-CM 250) [17], hyperlipidemia (ICD-9-CM 272) [18], hypertension (ICD-9-CM 401–405) [19], coronary artery disease (ICD-9-CM 410–414) [19], depression (ICD-9-CM 296.2, 296.3, 300.4, 311) [20], stroke (ICD-9-CM 430–438) [21], chronic obstructive pulmonary disease (ICD-9-CM 491–493, 496) [22], and chronic kidney disease (ICD-9-CM 580–589) [23]. …”
Section: Methodsmentioning
confidence: 99%