Chronic Kidney Disease and Cataract: Seeing the Light

Mack, Heather G; Savige, Judy

doi:10.1159/000475556

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…CKD is an emerging health problem worldwide affecting about 10% of the world`s population[ 20 ] and is associated with serious cardiovascular and renal problems and decreased quality of life. CKD is a progressive and irreversible problem resulting in end-stage renal disease (ESRD), which increases with increasing age and with chronic diseases such as diabetes, hypertension, and obesity.…”

Section: Anatomymentioning

confidence: 99%

Ocular manifestations in renal diseases

Gupta

Goyal

Gandhi

2023

Indian Journal of Ophthalmology

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The eyes and kidneys are the targets for end-organ damage in multiple pathologies. Both these organs develop during the same embryonic stage around the fourth to sixth week of gestation, thus sharing a strong correlation between both eye and kidney diseases. Both the eyes and kidneys can be the target of the systemic disease process; however, the eyes can also be affected as a consequence of renal disease or its treatment. Risk factors such as diabetes, hypertension, and smoking are commonly shared between kidney and eye diseases. Ocular manifestations can be predictive of renal disease, and/or patients with renal disease are at higher risk for developing ocular manifestations. Various congenital anomalies of the eyes and kidneys can also present as an oculorenal syndrome. This article summarizes the ocular pathology, which can be seen in renal diseases.

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Section: Anatomymentioning

confidence: 99%

Ocular manifestations in renal diseases

Gupta

Goyal

Gandhi

2023

Indian Journal of Ophthalmology

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“…Many factors with different mechanisms cause denaturing or proteolysis of lens proteins, resulting in loss of lens transparency and cataract formation (Nizami & Gulani, 2022). Some factors are genetic factors (Hejtmancik & Kantorow, 2004), maternal and fetal factors (Khurana, 2007), ocular trauma, radiation and prolonged exposure to sunlight (ultraviolet ray) (Wong et al, 2000), diabetes (Javadi & Zarei‐Ghanavati, 2008), kidney failure (Mack & Savige, 2017), NO production (Ito et al, 2001; Yadav et al, 2018), and oxidative stress (Truscott, 2005). Recent studies show that NO production has an important role in cataract development via signal transduction pathways or/and by induction of oxidative stress and apoptosis (Ito et al, 2001; Yadav et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The protective effect of pomegranate peel aqueous extract on selenite‐induced cataract in rats

Asl

Ashrafi

Aminlari

et al. 2022

Journal of Food Biochemistry

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The present study was performed to evaluate the preventive effect of pomegranate peel extract on sodium‐induced cataract in rats. Sprague–Dawley suckling male rats were divided into four groups: group C: rats received no treatment, group P: rats received pomegranate peel aqueous extract (PPE) orally, group Se: rats received an injection of sodium selenite, group Se + P: rats received PPE and sodium selenite concomitantly. After 4 weeks, rats were sacrificed, and their lenses were homogenized and evaluated for biochemical parameters and sodium dodecyl sulfate‐polyacrylamide gel electrophoresis. In the Se group, developed cataract with significant lens opacity was observed. Other changes in enzymatic and non‐enzymatic antioxidants, oxidative parameters, solubility of proteins, in NO and Ca levels and the electrophoresis pattern of proteins were observed in lenses of the Se group compared to control groups. After the preventive administration of PPE, most of these parameters were normalized due to antioxidant and anti‐inflammatory activities of the extract. Practical applications Cataract is one of the leading causes of vision impairment among the elderly, and surgery is the major therapeutic step taken to cure it. However, surgery has its limitations and complications. Therefore, prevention of cataract development, especially in high‐risk individuals, can be better than cure. Pomegranate peel extract has a high potential to prevent cataract in these people.

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“…Chronic kidney disease (CKD) is an emerging health problem worldwide affecting about 10% of the world`s population. [ 1 ] Diabetes and hypertension contribute to about two-third cases of CKD in the world. [ 2 ] CKD is irreversible and progressive process that results in end-stage renal disease (ESRD) where patient has to be dependent on renal replacement therapy for survival.…”

mentioning

confidence: 99%

Evaluation of changes in corneal endothelium in chronic kidney disease

Kanawa

Jain

Sagar

et al. 2021

Indian Journal of Ophthalmology

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Purpose: Chronic kidney disease (CKD) is an emerging health problem worldwide. In CKD corneal endothelial changes also occur probably due to accumulation of inflammatory cytokines and increased multiple toxic products. The aim of this study was to analyze the effect of CKD on corneal endothelium and correlate the findings with severity of disease with help of noninvasive technique. Methods: The study comprised 75 eyes of 75 cases divided into three groups with group A comprising of CKD cases on dialysis, group B of nondialysis CKD cases, and group C of controls. Each group had 25 cases each of either sex and between 15–80 age groups. All patients were investigated for blood urea, serum creatinine, and blood sugar and underwent complete ophthalmic examination of both eyes along with wide-field specular microscopy examination. Results: The majority of patients (33.3%) belonged to age range of 61–70 years with male predominance and the most common cause of CKD was found to be diabetes with 17 (34%) cases. We found normal corneal endothelial cell density (ECD) with the mean ECD of 2364.52 ± 397.72 mm 2 in the dialysis group, 2467.8 ± 352.88 mm 2 in nondialysis group, and 2521.68 ± 250.26 mm 2 in the control group of patients. However, we found significant increase in coefficient of variation (CV) with 36 ± 5.8% in dialysis group, 37 ± 4.5% in nondialysis group and 32 ± 0.8% in controls ( P = 0.001) and decreased hexagonality (Hx) with 47 ± 7.3% in dialysis group, 46 ± 4.7% in nondialysis group and 51 ± 6.7% in the controls ( P = 0.031). This showed increased tendency of pleomorphism and polymegathism in corneal endothelial cells in CKD cases. No correlation was found between blood urea or serum creatinine levels with endothelial parameters in any group. Conclusion: CKD causes morphological changes like polymegathism and pleomorphism in corneal endothelium and hence these cases are more vulnerable and special care should be taken before any intraocular surgical procedure.

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Chronic Kidney Disease and Cataract: Seeing the Light

Cited by 5 publications

References 6 publications

Ocular manifestations in renal diseases

Ocular manifestations in renal diseases

The protective effect of pomegranate peel aqueous extract on selenite‐induced cataract in rats

Evaluation of changes in corneal endothelium in chronic kidney disease

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