Chronic Kidney Disease and CHADS2 Score Independently Predict Cardiovascular Events and Mortality in Patients With Nonvalvular Atrial Fibrillation

Impact of Renal Dysfunction on Clinical Outcome in Patients With Low Risk of Atrial Fibrillation

“…Long-term mortality, cardiac events, and stroke risk were more than 8-fold higher when eGFR <60 ml · min −1 · 1.73 m −2 and CHADS2 score ≥2 were combined. 6 In the present study, we also found that decreased eGFR could independently predict thromboembolic events and cardiovascular death in patients with non-valvular AF. Moreover, in low-risk AF patients with CHA2DS2-VASc score 0-1, impaired renal function (eGFR <60 ml · min −1 · 1.73 m −2 ) was associated with significantly higher annual cardiovascular mortality and thromboembolic event rates compared with eGFR ≥60 ml · min −1 · 1.73 m −2 .…”

Renal Dysfunction, Stroke Risk Scores (CHADS 2 , CHA 2 DS 2 -VASc, and R 2 CHADS 2 ), and the Risk of Thromboembolic Events After Catheter Ablation of Atrial Fibrillation

“…28 In the Danish National Patient Registry, renal failure increased stroke risk ≤83%. 25 In another study, eGFR <60 mL/min per 1.73 m 2 was a significant predictor of stroke and cardiovascular events among patients with AF, independent of the CHADS 2 score, 29 in accordance with recently published studies. 25,30 Despite the known association between renal dysfunction and TE in AF, renal dysfunction has not been included in any of the current stroke stratification schemes although it was previously proposed that the small c in CHA 2 DS 2 -VASc score could represent informally chronic renal impairment.…”

Preventing Stroke in Patients With Chronic Kidney Disease and Atrial Fibrillation

“…23 Examining patients with eGFR <60 mL/min and an elevated stroke risk (CHADS 2 score ≥2) revealed an HR of 11.0 for ischemic stroke compared with patients with eGFR ≥60 mL/min and CHADS 2 score <2. 17 The up-to-date largest population is from a Danish national registry of 132 372 patients with AF and CKD and showed that patients with non-end-stage CKD compared with those without had a factor 1.49 increase (95% CI, 1.38-1.59) for stroke and systemic embolism. 24 Consistently, this large population study also showed that a more severe impairment of renal function is associated with a higher stroke risk (HR for patients with renal replacement therapy, 1.83; 95% CI, 1.57-2.14).…”

“…9 In another recently published study of 387 patients with AF, both eGFR and CHADS 2 score were strong independent predictors of all-cause (HR, 3.57; respective 3.16) and cardiovascular mortality (HR, 3.33; respective 5.53) in multivariate analysis. 17 For hemodialysis patients with AF, HRs for death between 1.16 and 2.32 compared with patients without AF were estimated. 14,[18][19][20] Another study found a 4-year mortality rate of 81% in patients with dialysis-dependent CKD and AF.…”