Chronic Kidney Disease and Nonalcoholic Fatty Liver Disease Proven by Transient Elastography

Abstract

Background/Aim: Preliminary data suggest an association between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to further investigate the association between NAFLD and decreased kidney function. Methods: A total of 62 patients with CKD were enrolled in the study. Liver stiffness was used to detect liver fibrosis and CAP (controlled attenuation parameter) was used to detect and quantify liver steatosis (Fibroscan®). NAFLD was defined by CAP values ≥238 dB.m^-1. Results: CKD stage III was present in 29 patients (46.8%) and CKD stage IV in 33 patients (53.2%). Out of 62 CKD patients 53 (85.5%) had NAFLD and of these 14/53 patients (26.4%) had also liver stiffness >7 kPa. The severity of liver steatosis was positively correlated with serum creatinine (r=0.399;p<0.01) and CRP (r=0.261; p<0.05) and negatively correlated with eGFR (r=-0.413; p<0.01) and serum iron concentration (r=-0.365; p<0.01). Conclusion: The results suggest a high prevalence of NAFLD in CKD patients. The severity of liver steatosis is negatively correlated with kidney function. The study documents the value of ultrasonographic elastography as an effective non-invasive screening method for the diagnosis of NAFLD.

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

“…Renal dysfunction is a major complication that accompanies NAFLD (Mikolasevic et al, 2013), which agrees our results (Table 2). Serum creatinine is increasingly being incorporated into prognostic models for patients with decompensated cirrhosis (Czaja, 2011;De Souza et al, 2014).…”

Non-Alcoholic Fatty Liver Disease Proven by Transient Elastography in Hemodialysis Patients: Is It a New Risk Factor for Adverse Cardiovascular Events?

“…We have also found a high prevalence of NAFLD in CKD patients. In our study the severity of liver steatosis was negatively correlated with kidney function [10]. …”

Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

“…In the last 5 years, a number of cross-sectional community-based and hospital-based studies have consistently demonstrated that NAFLD, as diagnosed either by imaging [16][17][18][19][20][21][22][23][24] or by histology [25][26][27][28][29] , is associated with an increased prevalence of CKD (defined as presence of decreased estimated glomerular filtration rate [eGFR] or abnormal albuminuria or overt proteinuria) in patients with NAFLD. In these studies, the prevalence of CKD in patients with NAFLD ranged from approximately 20% to 55% compared to 5%-30% in those without NAFLD [16][17][18][19][20][21][22][23][24][25][26][27][28][29] .…”

“…In these studies, the prevalence of CKD in patients with NAFLD ranged from approximately 20% to 55% compared to 5%-30% in those without NAFLD [16][17][18][19][20][21][22][23][24][25][26][27][28][29] . Notably, in most of these studies the association between NAFLD and CKD was independent of common cardio-renal risk factors across a wide range of patient populations.…”