Chronic kidney disease and the risk of incident hearing loss

Gupta, Shruti; Curhan, Sharon G.; Cruickshanks, Karen J.; Klein, Barbara E.K.; Klein, Ronald; Curhan, Gary C.

doi:10.1002/lary.28088

Cited by 11 publications

(11 citation statements)

References 45 publications

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“…Moreover, Lin et al [37] used data extracted from the Taiwan National Health Insurance Research Database, and found that the incidence of sudden sensorineural hearing loss (SSHL) was 1.57 times higher in the CKD group compared to the non-CKD group. In a prospective study of 1843 individuals, Gupta et al [38] found that lower eGFR was significantly associated with incident hearing loss at speech frequencies when estimated GFR with an equation that includes both SCr and cystatin C, but no significant association was found when GFR was estimated using SCr-based equation. The result was kind of inconsistent with ours and it may be due to the different study populations, different definition of hearing loss, and different SCr measurement.…”

Section: Discussionmentioning

confidence: 99%

The association between kidney function decline and hearing loss: a cross-sectional study

Liu

Meng

Wang

et al. 2019

Preprint

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Background The relationship between kidney function and hearing loss has long been recognized, but evidence mostly come from small observational studies. The aim of this study is to explore the association between kidney function decline and hearing loss in a large population-based study.Methods Data collected in the Chinese Health and Retirement Longitudinal Study (CHARLS) in 2015 was used for analysis. A cross-sectional study was conducted among 12508 participants aged 45 years and older. Hearing loss, the outcome of this study, was defined based on interviewees' responses to three survey questions about hearing in the CHARLS study. Estimated glomerular filtration rate (eGFR) was employed to assess kidney function, and participants were classified into three categories based on eGFR: ≥ 90, 60-89 and < 60 mL/min/1.73m2. Multivariable Logistic regression was employed to adjust for potential confounders, including demographics, health related behaviors, and cardiovascular risk factors.Results The overall prevalence of self-reported hearing loss in the study population was 23.55%. Compared with participants having eGFR ≥ 90 mL/min/1.73m2, there was an increased risk of hearing loss among those participants with eGFR of 60-89 mL/min/1.73m2 (odds ratio: 1.11, 95% confidence interval: 1.00-1.22) and eGFR < 60 mL/min/1.73m2 (odds ratio: 1.26, 95% confidence interval: 1.05-1.51) after adjusting for potential confounders.Conclusions Kidney function decline was independently associated with hearing loss.Testing for hearing should be included in the integrated management among patients with chronic kidney disease. BackgroundThe World Health Organization (WHO) reported that around 432 million adults suffer from disabling hearing loss in 2018, and it is estimated that over 900 million people will have disabling hearing loss by 2050 [1]. Hearing loss in adults not only bring communication difficulties in daily life, but also have negative impacts on cognitive and psychosocial function, lead to social isolation, cause financial strain and finally lower health-related quality of life indirectly [2][3][4]. As most hearing loss are acquired and hard to get recovered, but could be prevented, exploring the risk factors of hearing loss has great significance.

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Section: Discussionmentioning

confidence: 99%

The association between kidney function decline and hearing loss: a cross-sectional study

Liu

Meng

Wang

et al. 2019

Preprint

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“…Besides age and sex, we also considered the insurance fee and area of residence of the subjects. The common comorbidities including HT (ICD-9-CM codes 401-405) [30,31], DM (ICD-9-CM code 250) [32,33], stroke (ICD-9-CM codes 430-438) [34], head injury (ICD-9-CM codes 850-854) [22,23], CKD (ICD-9-CM code 585) [35,36], IHD (ICD-9-CM codes 410-414) [37,38], alcoholism (ICD-9-CM codes 305.0 and 303) [39,40], nicotine dependence (ICD-9-CM code 305.1) [41,42], asthma (ICD-9-CM code 493) [43][44][45], COPD (ICD-9-CM codes 490-492, 494, and 496) [46], and RA (ICD-9-CM code 714) [47] were considered as potential confounders.…”

Section: Main Outcome and Covariatesmentioning

confidence: 99%

“…Several etiological factors can cause SHL, such as loud noise [17,18], viral infection [14,19], genetic mutations [20,21], accidental events [22,23], ototoxicity [24][25][26], autoimmune diseases [27] and unknown illness-induced sudden SHL [28,29]. Several diseases such as hypertension (HT) [30,31], diabetes mellitus (DM) [32,33], stroke [34], chronic kidney disease (CKD) [35,36], ischemic heart disease (IHD) [37,38], alcoholism [39,40], nicotine dependence [41,42], asthma [43][44][45], chronic obstructive pulmonary disease (COPD) [46], and rheumatoid arthritis (RA) [47] are associated with SHL. Notably, some of these diseases can cause defects in the vascular system and microcirculation in the cochlea, subsequently resulting in hypoxia [48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Sensorineural Hearing Loss as a Result of Exposure to Air Pollution

Chang

Tsai

Lee

et al. 2020

IJERPH

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Whether exposure to air pollution is associated with developing sensorineural hearing loss (SHL) remains controversial. Using data from the National Health Insurance Research Database, we recruited a total of 75,767 subjects aged older than 20 years with no history of SHL from 1998 to 2010, and they were followed up until SHL was observed, they withdrew from the National Health Insurance program, or the study ended. The subjects were evenly exposed to low-level, mid-level, and high-level carbon monoxide (CO) and nitrogen dioxide (NO2). The incidence rate ratio of SHL for patients exposed to high-level CO was 1.24 (95% confidence interval (CI) = 1.14–1.36). The NO2 pollutants increased the incidence rate ratios of SHL in mid-level NO2 and high-level NO2 exposures by 1.10 (95% CI = 1.10–1.32) and 1.36 (95% CI = 1.24–1.49) times, respectively. The adjusted hazard ratio (adj. HR) of SHL in patients exposed to high-level CO was 1.45 (95% CI = 1.31–1.59), relative to that of patients exposed to low-level CO. Compared to patients exposed to low-level NO2, patients exposed to mid-level NO2 (adj. HR = 1.40, 95% CI = 1.27–1.54) and high-level NO2 (adj. HR = 1.63, 95% CI = 1.48–1.81) had a higher risk of developing SHL. The increased risk of SHL following the increased concentrations of air pollutants (CO and NO2) was statistically significant in this study. In conclusion, the subjects’ exposure to air pollution exhibited a significantly higher risk of developing SHL in Taiwan.

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“…But the sample size of their study was also relatively small and only the hearing status of two eGFR groups, i.e., ≥60 and <60 mL/min/1.73 m 2 were compared. However, Gupta et al [23] found that there is no significant association between GFR estimated using the serum creatinine-based equation and risk of incident hearing loss.…”

Section: Introductionmentioning

confidence: 99%

“…moderate CKD and hearing loss with an OR of 1.43 (95%CI, 1.10-1.84). In a prospective study of 1843 individuals, Gupta et al[23] estimated GFR by using an equation that considers SCr and cystatin C and found that lower eGFR is significantly associated with incident hearing loss at speech frequencies but not at high frequencies. However, when they estimated GFR by using an SCr-based equation, no significant association could be found between either lower baseline eGFR or decline in eGFR and incident hearing loss.…”

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confidence: 99%

The association between kidney function decline and hearing loss: a cross-sectional study

Liu

Meng

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The relationship between kidney function and hearing loss has long been recognized, but evidence of this association mostly comes from small observational studies or other populations. The aim of this study is to explore the association between kidney function decline and hearing loss in a large population-based study among the middle-aged and elderly Chinese. Methods: Data collected from the Chinese Health and Retirement Longitudinal Study (CHARLS) in 2015 were used for analysis. A cross-sectional study was conducted among 12508 participants aged 45 years and older. Hearing loss, the outcome of this study, was defined according to interviewees’ responses to three survey questions related to hearing in the CHARLS. Estimated glomerular filtration rate (eGFR) was employed to assess kidney function, and participants were classified into three categories based on eGFR: ≥90, 60-89 and <60 mL/min/1.73 m 2 . Multivariable logistic regression was employed to adjust for potential confounders, including demographics, health-related behaviors, and cardiovascular risk factors. Results: The overall prevalence of self-reported hearing loss in the study population was 23.55%. Compared with participants with eGFR ≥90 mL/min/1.73 m 2 , participants with eGFR of 60–89 mL/min/1.73 m 2 (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 1.00–1.23) and eGFR <60 mL/min/1.73 m 2 (OR: 1.25, 95% CI: 1.04–1.49) showed increased risk of hearing loss after adjusting for potential confounders. Conclusions: Kidney function decline is independently associated with hearing loss. Testing for hearing should be included in the integrated management of patients with chronic kidney disease.

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Chronic kidney disease and the risk of incident hearing loss

Cited by 11 publications

References 45 publications

The association between kidney function decline and hearing loss: a cross-sectional study

The association between kidney function decline and hearing loss: a cross-sectional study

Increased Risk of Sensorineural Hearing Loss as a Result of Exposure to Air Pollution

The association between kidney function decline and hearing loss: a cross-sectional study

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