Chronic kidney disease and the olfactory system

Robles‐Osorio, Ludivina; Corona, Rebeca; Morales, Teresa; Sabath, Ernesto

doi:10.1016/j.nefroe.2020.03.005

Cited by 12 publications

(22 citation statements)

References 22 publications

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“…ese characteristics lead to greater mental stress for patients, which further increases the possibility of patients suffering from mental illness. Depression is a common psychological and physical abnormal response that CKD patients often experience [19][20][21]. Once such emotion appears, the person is indifferent to the people or things around him, the appetite decreases, and the compliance decreases during the treatment and does not follow the doctor [22,23].…”

Section: Factors Affecting Mental Health Of Patientsmentioning

confidence: 99%

Diagnosis and Treatment Rules of Chronic Kidney Disease and Nursing Intervention Models of Related Mental Diseases Using Electronic Medical Records and Data Mining

Wang

Sun

et al. 2021

Journal of Healthcare Engineering

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Objective. On the basis of electronic medical records, the data mining technology was adopted to explore the law of chronic kidney disease (CKD) and the intervention mode of mental health of patients. Methods. Based on the electronic medical records, the corresponding data extraction, database establishment, and data cleaning of CKD were performed. After that, the related data analysis, frequency analysis, cluster analysis, and nonparametric analysis were used to explore the laws of CKD diagnosis and treatment and nursing intervention mode of mental illness. The most common causes of CKD were chronic glomerulonephritis (43.76%), aristolochic acid nephritis (16.34%), diabetic nephritis (12.87%), and hypertensive nephritis (11.58%). The major treatment method for end-stage patients was alternative therapies, accounting for 46%. Compared with the depression score before intervention, that of the patients after the mindfulness therapy (50.99 ± 9.77 vs. 47.01 ± 9.33, P = 0.024 < 0.5 ) and target behaviour nursing intervention (52.21 ± 8.12 vs. 48.01 ± 9.33, P = 0.032 < 0.05 ) was obviously decreased. Conclusion. The data mining technology based on electronic records showed a good application prospect in the analysis of the diagnosis and treatment of CKD; and target behaviour nursing and mindfulness intervention were effective psychological intervention models.

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Section: Factors Affecting Mental Health Of Patientsmentioning

confidence: 99%

Diagnosis and Treatment Rules of Chronic Kidney Disease and Nursing Intervention Models of Related Mental Diseases Using Electronic Medical Records and Data Mining

Wang

Sun

et al. 2021

Journal of Healthcare Engineering

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“…Previous literature supported the role of uremia on olfactory dysfunction as there was an improvement in olfactory function among kidney transplant recipients and post dialysis. Additionally, it also suggested high plasticity and recovery capacity of the olfactory neurons after elimination of uremic toxins [ 1 , 25 , 26 ]. Interestingly, olfactory G protein-coupled receptors are also found in kidneys.…”

Section: Discussionmentioning

confidence: 99%

“…The dysfunction in smell leads to food aversion, decreased appetite and inadequate food intake, which predisposes to poor nutritional status and malnutrition. Alternatively, poor nutritional status leads to vitamins and trace elements deficiencies which attribute to olfactory dysfunction [ 1 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Olfactory and gustatory dysfunction are common in the general population, especially among the elderly, but are rarely recognized and addressed [ 1 ]. Previous analyses of National Health and Nutrition Examination Survey (NHANES) have reported the prevalence of olfactory dysfunction was 14% and gustatory dysfunction was 18% among general population [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Olfactory and gustatory dysfunction have been shown to be associated with anorexia and food aversion. These symptoms lead to poor nutritional status, fatigue, weakness, and malnutrition which contribute to increased morbidity and mortality [ 1 , 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

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The association between olfactory and gustatory dysfunction and chronic kidney disease

et al. 2022

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Background Olfactory and gustatory changes may contribute to poor appetite and food aversion in chronic kidney disease (CKD), though the prevalence of olfactory and gustatory dysfunction is not known in the CKD population. Methods We conducted a cross-sectional study among 3527 US adults aged ≥40 years old in the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2014. We measured the prevalence of olfactory and gustatory dysfunction among patients with CKD defined as eGFR < 60 ml/min/1.73m2 using the “scratch and sniff” NHANES Pocket Smell Test and quinine whole-mouth test. We also examined the association between CKD and olfactory/gustatory dysfunction, and nutritional markers. Results The prevalence of olfactory dysfunction was 30% among CKD and 15% among non-CKD (p < 0.001). The prevalence of gustatory dysfunction was 13% among CKD and 17% among non-CKD (p = 0.10). After adjusting for confounders, CKD was significantly associated with olfactory dysfunction (OR = 1.47, 95% CI [1.07, 2.01]; p = 0.02) but not gustatory dysfunction (OR = 1.76, 95%CI [0.99, 3.11]; p = 0.05). Among the CKD population, the odds of olfactory dysfunction was 72% higher for every 10 kg decrease in grip strength (OR = 1.72, 95% CI [1.39, 2.13]; adjusted p = 0.005). Conclusion CKD was associated with higher odds of olfactory but not gustatory dysfunction. Olfactory dysfunction was associated with lower grip strength among those with CKD. Screening and early intervening on olfactory dysfunction among CKD may preserve muscle strength and improve nutritional status in this vulnerable population.

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International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

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Background:The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. Results:The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. Conclusion:This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

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Chronic kidney disease and the olfactory system

Cited by 12 publications

References 22 publications

Diagnosis and Treatment Rules of Chronic Kidney Disease and Nursing Intervention Models of Related Mental Diseases Using Electronic Medical Records and Data Mining

Diagnosis and Treatment Rules of Chronic Kidney Disease and Nursing Intervention Models of Related Mental Diseases Using Electronic Medical Records and Data Mining

The association between olfactory and gustatory dysfunction and chronic kidney disease

International consensus statement on allergy and rhinology: Olfaction

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