Chronic Kidney Disease as an Independent Risk for Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan  Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, Sanae; Tsuchihashi-Makaya, Miyuki; Kinugawa, Shintaro; Yokota, Takashi; Ide, Tomomi; Takeshita, Akira; Tsutsui, Hiroyuki

doi:10.1253/circj.cj-09-0062

Cited by 83 publications

(47 citation statements)

References 21 publications

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“…4 In our previous study using the same patient JCARE-CARD database, there was a 1.4% increase in the risk for all-cause death or rehospitalization due to worsening HF for each 1-ml · min -1 · 1.73 m -2 decrease in eGFR after multivariable adjustment, and lower eGFR was associated with poor outcomes even in the subgroup of patients older than 65 years. 7 Therefore, EHFS II as well as JCARE-CARD confirmed prognostic implications of renal dysfunction in elderly patients with HF. These findings indicate the need to manage and care for renal dysfunction to prevent adverse outcomes, especially in elderly patients with HF.…”

Section: Discussionmentioning

confidence: 74%

Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) -

Hamaguchi

Kinugawa

Goto

et al. 2011

Circ J

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Section: Discussionmentioning

confidence: 74%

Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) -

Hamaguchi

Kinugawa

Goto

et al. 2011

Circ J

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“…The risks of CKD included not only the progression to end-stage renal failure but also the occurrence of adverse cardiovascular outcomes. [5][6][7][8][9] Previous studies have demonstrated that CKD is an independent risk factor for morbidity and mortality in the general population, 10 as well as in patients with cardiovascular diseases such as post acute myocardial infarction (AMI). 11 Anavekar et al 11 reported that CKD was a common and significant independent risk factor for cardiovascular events in AMI patients based on data from the Valsartan in Acute Myocardial Infarction Trial (VALIANT).…”

Section: Introductionmentioning

confidence: 99%

Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction: report from the Hokkaido acute myocardial infarction registry

et al. 2012

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on behalf of Hokkaido Acute Myocardial Infarction Registry InvestigatorsRenal dysfunction is a significant risk factor in the prognosis of patients with cardiovascular diseases. We sought to determine the relationship between estimated glomerular filtration rate (eGFR) values and in-hospital mortality in Japanese acute myocardial infarction (AMI) patients. A total of 2266 consecutive AMI patients admitted to 22 hospitals in Hokkaido were registered. The eGFR values were determined using the following equation: eGFR¼194Â(serum creatinine) À1.094 Â(age) À0.287 (Â0.739 if female). Patients were classified into four groups according to their eGFR values: X60 (n¼1304), 30-59 (n¼810), 15-29 (n¼87) and o15 ml min À1 per 1.73 m 2 (n¼65). A total of 110 patients (4.9%) died during hospitalization. The in-hospital mortality rate was significantly higher in patients with reduced eGFR values at 2.3, 5.4, 24.1 and 23.1% for eGFR values of X60, 30-59, 15-29, and o15 ml min À1 per 1.73 m 2 , respectively. The odds ratios for in-hospital all cause death were 8.26 (95% confidence interval (CI): 2.22-30.77) for eGFRo15 ml min À1 per 1.73 m 2 and 3.42 (95% CI: 1.01-11.61) for eGFR 15-29 ml min À1 per 1.73 m 2 compared with eGFR X60 ml min À1 per 1.73 m 2 . Similarly, the odds ratios for in-hospital cardiac death were 8.43 (95% CI: 1.82-39.05) for eGFRo15 ml min À1 per 1.73 m 2 and 5.47 (95% CI: 1.51-19.80) for eGFR 15-29 ml min À1 per 1.73 m 2 . In conclusion, the eGFR of o30 ml min À1 per 1.73 m 2 was a significant and independent risk for in-hospital mortality in abroad cohort of Japanese patients with AMI.

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“…6 HF patients with CKD or ESRD show a worse prognosis. 7 In the Acute Decompensated Heart Failure National Registry (ADHERE), 30% of hospitalized patients with acute HF had a history of chronic renal failure (serum creatinine level >2 mg/dl). 8 It also showed that admission levels of serum creatinine and blood urea nitrogen were among the strongest independent risk predictors for in-hospital mortality.…”

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confidence: 99%

Heart Failure, Chronic Kidney Disease, and Biomarkers - An Integrated Viewpoint -

Iwanaga

Miyazaki

2010

Circ J

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Chronic kidney disease (CKD) is frequently associated with a progressive decrease in the glomerular filtration rate, which leads to endstage renal disease (ESRD). Heart failure (HF) is a complex syndrome rather than a primary diagnosis, and considered as the endpoint of all cardiovascular disorders. It is the leading cause of death among the cardiovascular diseases in patients with CKD and ESRD. There is some interaction between the heart and kidney (the so-called "cardiorenal syndrome"), and HF patients with the complication of CKD or ESRD show a worse prognosis. Thus, early diagnosis and aggressive management of HF are needed in patients with CKD and ESRD. A number of biomarkers appear to have growing clinical importance and are reported for detection and stratification of HF. Although HF and CKD have a close interrelationship, the utility of the biomarkers has not been adequately studied with regard to the relationship with renal dysfunction. This paper reviews of the current evidence about laboratory biomarkers in patients with HF or CKD, emphasizing the emerging cardiac biomarkers (ie, BNPs and cardiac troponins), and the biomarkers of renal injury (ie, cystatin C and neutrophil gelatinase-associated lipocalin). Furthermore, it discusses the potential role of these markers in terms of heart -kidney interactions and their utility in the diagnostic and therapeutic strategies for cardiorenal syndrome. (Circ J 2010; 74: 1274 - 1282

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Chronic Kidney Disease as an Independent Risk for Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Cited by 83 publications

References 21 publications

Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) -

Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) -

Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction: report from the Hokkaido acute myocardial infarction registry

Heart Failure, Chronic Kidney Disease, and Biomarkers - An Integrated Viewpoint -

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