Chronic kidney disease in HIV infection: an urban epidemic

Wyatt, Christina M.; Winston, Jonathan; Malvestutto, Carlos; Fishbein, Dawn; Barash, Irina; Cohen, Alan; Klotman, Mary E.; Klotman, Paul E.

doi:10.1097/qad.0b013e3282ef1bb4

Cited by 154 publications

(139 citation statements)

References 11 publications

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“…HIV-infected persons are at higher risk for proteinuria, CKD, and ESRD compared with uninfected individuals, even after controlling for traditional kidney disease risk factors (1)(2)(3)(4)(5)(6). However, standard clinical measures of kidney disease, such as serum creatinine and dipstick proteinuria, are inadequate in their ability to detect early kidney damage (7).…”

Section: Introductionmentioning

confidence: 99%

Association of Urine α1-Microglobulin with Kidney Function Decline and Mortality in HIV-Infected Women

Jotwani

Scherzer

Abraham

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives Despite advances in therapy, HIV-infected individuals remain at higher risk for kidney dysfunction than uninfected individuals. It was hypothesized that urine levels of a1-microglobulin, a biomarker of proximal tubular dysfunction, would predict kidney function decline and mortality risk in HIV-infected and uninfected women.Design, setting, participants, & measurements In the Women's Interagency HIV Study, urine a1-microglobulin and creatinine concentrations were measured in 903 HIV-infected and 287 uninfected women using stored urine from 1999 to 2000, when prevalence of tenofovir use was ,1%. Participants were categorized into three categories by level of a1-microglobulin-to-creatinine ratio, and associations with kidney decline and all-cause mortality over 8 years were evaluated.Results Urine a1-microglobulin was detectable in 60% of HIV-infected and 40% of uninfected women (P,0.001). Among HIV-infected women, there were 177 (22%), 61 (7%), and 128 (14%) patients with incident CKD, with 10% annual eGFR decline, and who died, respectively. Compared with HIV-infected women in the lowest a1-microglobulin category, HIV-infected women in the highest a1-microglobulin category had a 2.1-fold risk of incident CKD (95% confidence interval, 1.3 to 3.4), 2.7-fold risk of 10% annual eGFR decline (95% confidence interval, 1.2 to 5.9), and 1.6-fold mortality risk (95% confidence interval, 1.0 to 2.6) in models adjusting for kidney risk factors, baseline eGFR, and albuminuria. Among uninfected women, the highest a1-microglobulin category was associated with 3% (relative risk, 2.2; 95% confidence interval, 1.4 to 3.5) and 5% (relative risk, 2.2; 95% confidence interval, 1.1 to 4.3) annual eGFR decline relative to the lowest a1-microglobulin category.Conclusions Proximal tubular dysfunction, indicated by urine a1-microglobulin, was independently associated with kidney function decline in HIV-infected and uninfected women and mortality risk among HIV-infected women.

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Section: Introductionmentioning

confidence: 99%

Association of Urine α1-Microglobulin with Kidney Function Decline and Mortality in HIV-Infected Women

Jotwani

Scherzer

Abraham

et al. 2015

Clinical Journal of the American Society of Nephrology

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“…Krawczyk et al had found in the United States that taking anti-hypertensive treatment is a factor associated with chronic kidney failure (p=0.004) [18]. It's important to note also that hypertension is one of the criteria used by the Infectious Diseases Society of America (IDSA) to describe HIV patients with a high risk of developing kidney disease [19].…”

Section: Prevalence Of Chronic Kidney Failure In People With Hivmentioning

confidence: 99%

Prevalence of Chronic Kidney Failure and Associated Factors in Patients Treated by Antiretroviral in the National Teaching Hospital of Cotonou

Dm¹,

Vigan²,

Azon-Kouanou³

et al. 2015

J Nephrol Ther

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“…The risk of both acute kidney injury and chronic renal disease is increased in human immunodeficiency virus (HIV) patients compared with the general population [1]. After the introduction of highly active antiretroviral treatment (HAART), arterial hypertension, diabetes, atherosclerosis and drug toxicity are gaining relevance in the HIV patient as risk factors for the development of kidney disease.…”

Section: Introductionmentioning

confidence: 99%

Long-term comparative and prospective cohort study of renal function in patients with HIV infection treated with tenofovir disoproxil fumarate

Calle¹,

Pulido²,

Sánchez-Conde³

et al. 2017

HIV & AIDS Review

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Chronic kidney disease in HIV infection: an urban epidemic

Cited by 154 publications

References 11 publications

Association of Urine α1-Microglobulin with Kidney Function Decline and Mortality in HIV-Infected Women

Association of Urine α1-Microglobulin with Kidney Function Decline and Mortality in HIV-Infected Women

Prevalence of Chronic Kidney Failure and Associated Factors in Patients Treated by Antiretroviral in the National Teaching Hospital of Cotonou

Long-term comparative and prospective cohort study of renal function in patients with HIV infection treated with tenofovir disoproxil fumarate

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