Chronic kidney disease is associated with increased carotid artery stiffness without morphological changes in participants of health check-up programs

Makita, Shinji; Abiko, Akihiko; Naganuma, Yujirou; Nagai, Mizuyoshi; Nakamura, Motoyuki

doi:10.1016/j.atherosclerosis.2010.08.057

Cited by 12 publications

(13 citation statements)

References 33 publications

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“…Notably, these results were similar when CKD was defined by creatinine. Another study by Makita et al [6] further expanded the observation by documenting that arterial stiffness increases in early CKD stages even in the absence of disease of the intimal layer of the arterial wall and independently of traditional CV risk factors [6]. …”

Section: Arterial Stiffness and Chronic Kidney Disease: A Vicious mentioning

confidence: 99%

Arterial Stiffness in Chronic Kidney Disease: The Usefulness of a Marker of Vascular Damage

Bellasi

Ferramosca²,

Ratti³

2011

International Journal of Nephrology

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Increased arterial stiffness is a marker of vasculopathy in chronic kidney disease (CKD) patients, suggesting a significant cardiovascular damage. Detection of arterial stiffness provides physicians with useful prognostic information independent of traditional cardiovascular (CV) risk factors. In addition, this knowledge may help guide appropriate therapeutic choices and monitor the effectiveness of antihypertensive therapies. We review the relationship between arterial stiffness and CKD, as well as the prognostic implications of increased arterial stiffness and the potential therapeutic strategies to ameliorate arterial compliance and outcome in CKD.

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Section: Arterial Stiffness and Chronic Kidney Disease: A Vicious mentioning

confidence: 99%

Arterial Stiffness in Chronic Kidney Disease: The Usefulness of a Marker of Vascular Damage

Bellasi

Ferramosca²,

Ratti³

2011

International Journal of Nephrology

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“…Similar observation has been made by a Japanese study. [ 26 ] However, in contrast to our study, this study defined kidney disease as eGFR <60 ml/min/1.73 m 2 and/or presence of proteinuria. While in the absence of proteinuria data (or measured GFR) the diagnosis of mild CKD is less secure, it is interesting to note that the observations are similar in the two studies.…”

Section: Discussionmentioning

confidence: 63%

Measurement of arterial stiffness in subjects with and without renal disease: Are changes in the vessel wall earlier and more sensitive markers of cardiovascular disease than intima media thickness and pulse pressure?

Claridge¹,

Wilmink²,

Ferring³

et al. 2015

Indian J Nephrol

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There is increased cardiovascular (CV) mortality in subjects with chronic kidney disease (CKD). Arterial stiffness in these subjects is increased when compared to a healthy population. Markers of arterial stiffness and intima media thickness (IMT) are predictors of CV mortality. The aim of this study was to investigate whether there is any difference in markers of arterial stiffness and IMT between subjects with normal renal function and those with mild renal disease. The arterial distension waveform, IMT, diameter, and brachial blood pressure were measured to calculate Young's modulus (E) and elastic modulus (Ep) in the common carotid arteries of subjects with normal kidney function (estimated glomerular filtration rate [eGFR] >90) and those mild CKD (stage 2, eGFR 89–60). Data were available for 15 patients with normal kidney function and 29 patients with mild CKD. The subjects with mild CKD were older, but other co-variables were not significantly different. Both arterial wall stiffness parameters (E and Ep), but not IMT were significantly higher in the mild CKD group. Logistic regression demonstrated that only the arterial wall stiffness parameters (Ep and E) were independently associated with mild renal disease compared with normal, in a model adjusting for sex, age and diabetes and history of cardiovascular disease (CVD). E and Ep may be early markers of CVD in subjects with mild CKD that may manifest change before other more recognized markers such as IMT and pulse pressure.

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“… 23 A previous study showed that a reduced eGFR was associated with increased carotid arterial stiffness without progression of intimal disease, such as increased IMT or plaque formation. 24 Additionally, the eGFR is not associated with an increased IMT after adjusting for traditional cardiovascular disease risk factors. 25 , 26 Taken together, these findings suggest that maximum-IMT is not a useful surrogate marker of coronary artery stenosis in patients with renal impairment.…”

Section: Discussionmentioning

confidence: 95%

Risk factors and utility of maximum carotid intima–media thickness as a surrogate marker for coronary artery stenosis

Hirai

Imamura

Hirai

et al. 2018

TCRM

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BackgroundThis study investigated the factors associated with coronary artery stenosis in outpatients. Furthermore, the usefulness of maximum carotid intima–media thickness (maximum-IMT) as a surrogate marker of coronary artery stenosis was evaluated.MethodsWe conducted a single-center retrospective study. A total of 601 outpatients (338 males; 263 females; mean age, 69.8±10.0 years) who underwent coronary computed tomography angiography between April 2006 and March 2012 were analyzed. The associations between coronary artery stenosis (≥75%) as determined by coronary computed tomography angiography and clinical and laboratory parameters were evaluated by multivariate logistic regression. Validation of maximum-IMT as measured by ultrasonography as a surrogate marker of coronary artery stenosis was analyzed by receiver operating characteristic (ROC) curve analysis.ResultsThe estimated glomerular filtration rate (eGFR: mL/min/1.73 m2) (odds ratio [OR] 0.985, p<0.01), diabetes mellitus (OR 1.98, p<0.05), and maximum-IMT (mm) (OR 1.76, p<0.01) were significantly associated with coronary artery stenosis (≥75%). In analysis of each group categorized by identified factors, such as renal impairment (eGFR <60 mL/min/1.73 m2) and diabetes mellitus, the ROC curve of maximum-IMT was significant in the group of patients with diabetes mellitus without renal impairment (p<0.01) (cutoff value of maximum-IMT, 2.0 mm; sensitivity, 0.74; and specificity, 0.54) but not in other groups.ConclusionRenal impairment, diabetes mellitus, and increased maximum-IMT may be significant risk factors of coronary artery stenosis. Maximum-IMT as measured by ultrasonography may be a useful surrogate marker for coronary artery stenosis in patients with diabetes mellitus without renal impairment but not in other patients.

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Chronic kidney disease is associated with increased carotid artery stiffness without morphological changes in participants of health check-up programs

Cited by 12 publications

References 33 publications

Arterial Stiffness in Chronic Kidney Disease: The Usefulness of a Marker of Vascular Damage

Arterial Stiffness in Chronic Kidney Disease: The Usefulness of a Marker of Vascular Damage

Measurement of arterial stiffness in subjects with and without renal disease: Are changes in the vessel wall earlier and more sensitive markers of cardiovascular disease than intima media thickness and pulse pressure?

Risk factors and utility of maximum carotid intima–media thickness as a surrogate marker for coronary artery stenosis

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Chronic kidney disease is associated with increased carotid artery stiffness without morphological changes in participants of health check-up programs

Cited by 12 publications

References 33 publications

Arterial Stiffness in Chronic Kidney Disease: The Usefulness of a Marker of Vascular Damage

Arterial Stiffness in Chronic Kidney Disease: The Usefulness of a Marker of Vascular Damage

Measurement of arterial stiffness in subjects with and without renal disease: Are changes in the vessel wall earlier and more sensitive markers of cardiovascular disease than intima media thickness and pulse pressure?

Risk factors and utility of maximum carotid intima&ndash;media thickness as a surrogate marker for coronary artery stenosis

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Risk factors and utility of maximum carotid intima–media thickness as a surrogate marker for coronary artery stenosis