Chronic kidney disease, lipids and apolipoproteins, and coronary heart disease: The ARIC Study

Lamprea‐Montealegre, Julio A.; Sharrett, A. Richey; Matsushita, Kunihiro; Selvin, Elizabeth; Szklo, Moysés; Astor, Brad C.

doi:10.1016/j.atherosclerosis.2014.02.006

Cited by 50 publications

(61 citation statements)

References 19 publications

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“…Although non-HDL-c/HDL-c is a well-studied risk factor for CVD [13-15], this study is one of the first reporting its association with kidney disease [26]. Our study is also one of the first to relate varying lipid parameters to kidney disease using the novel CKD-EPI equation, which is as accurate as the MDRD Study equation at GFR<60 ml/min/1.73 m 2 but is more accurate at higher GFRs [17].…”

Section: Discussionmentioning

confidence: 99%

“…Non-HDL-c is calculated as TC minus HDL-c and includes all of the atherogenic lipoproteins [13], such as TG-rich lipoproteins, intermediate-density lipoprotein cholesterol (IDL-c), LDL-c, and lipoprotein(a) (Lp(a)). Data from the Third National Health and Nutrition Examination Survey [14], the Swedish National Diabetes Register [15], and the Atherosclerosis Risk in Communities study [13] confirmed that the predictive value of non-HDL-c/HDL-c for cardiovascular risk is as good as, if not better than, that of non-HDL-c, implying that non-HDL-c/HDL-c more closely reflects the complex interactions of lipoprotein metabolism and can better predict plasma atherogenicity than isolated lipid values. However, few studies have demonstrated whether non-HDL-c/HDL-c can predict renal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have also revealed that the TG/HDL-c ratio is more closely correlated with the incidence of hypertension [9], coronary heart disease [10], CVD [11] and albuminuria [12] than individual lipid profiles are. Meanwhile, non-HDL-c is calculated as TC minus HDL-c and includes all the atherogenic lipoproteins [13]. Several prospective studies have shown that non-HDL-c/HDL-c may be a better predictor of CVD than LDL-c, non-HDL-c, apolipoprotein B (apoB) or apolipoprotein A1 (apoA1) [13-15].…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, non-HDL-c is calculated as TC minus HDL-c and includes all the atherogenic lipoproteins [13]. Several prospective studies have shown that non-HDL-c/HDL-c may be a better predictor of CVD than LDL-c, non-HDL-c, apolipoprotein B (apoB) or apolipoprotein A1 (apoA1) [13-15]. However, published data on the association between non-HDL-c/HDL-c and CKD are limited.…”

Section: Introductionmentioning

confidence: 99%

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Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Wen

Chen

Huang

et al. 2017

Kidney Blood Press Res

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Background/Aims: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. Methods: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m² or dipstick-positive proteinuria. Logistic regression models were used to examine the relationship between lipid variables and CKD. Results: The prevalence of CKD in this study was 3.7%. When the participants exhibited higher serum triglyceride (TG), a higher TG/high-density lipoprotein cholesterol (TG/HDL-c) ratio or a higher non-HDL-c/HDL-c ratio or HDL-c in a lower quartile, the prevalence of CKD tended to be higher. The multivariate adjusted odds ratios for CKD per 1 standard deviation increase in lipid level were 1.17 (1.10-1.23) for TG, 0.86 (0.79-0.93) for HDL-c, 1.21 (1.13-1.31) for the TG/HDL-c ratio, and 1.14 (1.06-1.22) for the non-HDL-c/HDL-c ratio. No significant association was detected between CKD and total cholesterol (TC), non-HDL-c or the low-density lipoprotein cholesterol/HDL-c (LDL-c/HDL-c) ratio. Conclusion: In this relatively healthy adult Chinese population, the CKD-EPI equation determined that the TG/HDL-c and non-HDL-c/HDL-c ratios as well as TG and HDL-c correlate with the prevalence of CKD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Wen

Chen

Huang

et al. 2017

Kidney Blood Press Res

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“…Non-HDL-cholesterol, which is estimated by subtracting HDLc from total cholesterol, corresponds closely to measurements of ApoB [9]. With respect to the NonHDLc/HDLc ratio, the UK Prospective Diabetes Study found NonHDLc/HDLc ratio to be better than NonHDLc as a predictor of coronary heart disease (CHD) in patients with type 2 diabetes [10].…”

Section: Introductionmentioning

confidence: 99%

Non-HDL-cholesterol to HDL-cholesterol ratio as an independent risk factor for the development of chronic kidney disease

Zuo¹,

Chen²,

Liu

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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Total‐, LDL‐, and HDL‐cholesterol, apolipoproteins, and triglycerides with risk of total and fatal prostate cancer in Black and White men in the ARIC study

et al. 2023

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Background: Cholesterol reduction is considered a mechanism through which cholesterol-lowering drugs including statins are associated with a reduced aggressive prostate cancer risk. While prior cohort studies found positive associations between total cholesterol and more advanced stage and grade in White men, whether associations for total cholesterol, low (LDL)-and high (HDL)density lipoprotein cholesterol, apolipoprotein B (LDL particle) and A1 (HDL particle), and triglycerides are similar for fatal prostate cancer and in Black men, who experience a disproportionate burden of total and fatal prostate cancer, is unknown. Methods:We conducted a prospective study of 1553 Black and 5071 White cancerfree men attending visit 1 (1987)(1988)(1989) of the Atherosclerosis Risk in CommunitiesStudy. A total of 885 incident prostate cancer cases were ascertained through 2015, and 128 prostate cancer deaths through 2018. We estimated multivariable-adjusted hazard ratios (HRs) of total and fatal prostate cancer per 1-standard deviation increments and for tertiles (T1-T3) of time-updated lipid biomarkers overall and in Black and White men.

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Chronic kidney disease, lipids and apolipoproteins, and coronary heart disease: The ARIC Study

Cited by 50 publications

References 19 publications

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Non-HDL-cholesterol to HDL-cholesterol ratio as an independent risk factor for the development of chronic kidney disease

Total‐, LDL‐, and HDL‐cholesterol, apolipoproteins, and triglycerides with risk of total and fatal prostate cancer in Black and White men in the ARIC study

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