Chronic kidney disease of unknown etiology: Mystery unsolved

Mangala, P; Silva, CS De

doi:10.4038/jur.v2i1-2.7848

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…Ribavirin is a guanosine analogue antiviral with activity against DNA and RNA viral polymerases that has been showing promising results against SARS-CoV-2 (Alhazzani et al, 2020;Khalili et al, 2020;Yousefi et al, 2020;. Although this compound is established among the first five antiviral drugs tested in vitro against SARS-CoV-2 due to its promising results against previous SARS and MERS infections (Morgenstern et al, 2005;Wohlford-Lenane et al, 2009;Khalili et al, 2020), some authors indicated a need of dose reduction on the new coronaviruses treatment (McCray et al, 2020). The prophylactic use of this drug includes the association with lopinavir and ritonavir, or interferon-α (INFα), instead of monotherapy.…”

Section: Discussionmentioning

confidence: 99%

Repurposing Approved Drugs for Guiding COVID-19 Prophylaxis: A Systematic Review

et al. 2020

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The SARS-CoV-2 outbreak originally appeared in China in December 2019 and became a global pandemic in March 2020. This infectious disease has directly affected public health and the world economy. Several palliative therapeutic treatments and prophylaxis strategies have been used to control the progress of this viral infection, including pre-(PrEP) and post-exposure prophylaxis. On the other hand, research groups around the world are still studying novel drug prophylaxis and treatment using repurposing approaches, as well as vaccination options, which are in different pre-clinical and clinical testing phases. This systematic review evaluated 1,228 articles from the PubMed and Scopus indexing databases, following the Kitchenham bibliographic searching protocol, with the aim to list drug candidates, potentially approved to be used as new options for SARS-CoV-2 prophylaxis clinical trials and medical protocols. In searching protocol, we used the following keywords: “Covid-19 or SARS-CoV-2” or “Coronavirus or 2019 nCoV,” “prophylaxis,” “prophylactic,” “pre-exposure,” “COVID-19 or SARS-CoV-2 Chemoprophylaxis,” “repurposed,” “strategies,” “clinical,” “trials,” “anti-SARS-CoV-2,” “anti-covid-19,” “Antiviral,” “Therapy prevention in vitro,” in cells “and” human testing. After all protocol steps, we selected 60 articles that included: 15 studies with clinical data, 22 studies that used in vitro experiments, seven studies using animal models, and 18 studies performed with in silico experiments. Additionally, we included more 22 compounds between FDA approved drugs and drug-like like molecules, which were tested in large-scale screenings, as well as those repurposed approved drugs with new mechanism of actions. The drugs selected in this review can assist clinical studies and medical guidelines on the rational repurposing of known antiviral drugs for COVID-19 prophylaxis.

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Section: Discussionmentioning

confidence: 99%

Repurposing Approved Drugs for Guiding COVID-19 Prophylaxis: A Systematic Review

et al. 2020

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“…Higher levels of arsenic have been observed in rice produced in CKDu endemic areas and groundwater there, also in urine, hair, and other parts of the patient body, supporting the hypothesis. Palms and soles keratosis and hyperpigmentation which are symptoms of arsenic poisoning have also been observed in CKDu patients (Mangala and De Silva, 2014). This arsenic which is coming from pesticides and other fertilizers react with calcium in hard water forming calcium arsenate crystals which interrupts renal tissues' antioxidant defense system when get into kidneys.…”

Section: Relationship Between Social and Occupation Risk Factorsmentioning

confidence: 98%

Identification of Social and Occupational Risk Factors Associated with CKDu Patients in an Agricultural Community in Kebithigollewa, Sri Lanka

Lowe

Kumarasinghe

2021

Preprint

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Aim: To identify the social and occupational risk factors associated with CKDu patients living in an agricultural community in Kebithigollewa, Sri Lanka.Methods: A three months community based cross sectional study was done involving 30 CKDu diagnosed patients who were attending the CKDu Ayurvedic Clinic at Kebithigollewa, North Central Province (NCP), Sri Lanka and 30 controls were taken from the same region. Socioeconomic and socio-demographic data was collected from the participants with the use of an interview administered questionnaire. Heights and weights were the anthropometric data measured for the study. Blood samples were collected as biochemical data which was later analysed using an automated blood analyser. Data collected was computerized and analysed using software Graphpad Prism 8 and SPSS version 20.Results: All the participants of the research were active residents living in the North Central Province (NCP) since birth. 83.34% of the CKDu affected individuals were from the 4th to 7th decade of life and 70% of them were males. 86.66% of the affected population carried out agricultural practices as their main source of income with chena and paddy cultivation being the common practice followed. 96.66% of the affected were from low income families who earned 0-20000 LKR per month. 40% of the affected have had only up to five years of school education. 63.33% of the CKDu patients were overweight. A significant correlation of 0.642218 was shown by Cramer’s V square test between Number of working hours/day and serum creatinine, indicating a strong association, but did not have a significant nominal logistic regression.Conclusion: Serum creatinine was high in farmers and laborers indicating that occupation impacts CKDu occurrence and progression. It was also high in age group 31-50yrs showing a significant relationship with serum creatinine which indicates the social impact on CKDu occurrence. A statistically significance of P<0.05 was shown by number of working hours and BMI.

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“…Higher levels of arsenic have been observed in rice produced in CKDu endemic areas and groundwater there, also in urine, hair, and other parts of the patient body, supporting the hypothesis. Palms and soles keratosis and hyperpigmentation which are symptoms of arsenic poisoning have also been observed in CKDu patients [22]. This arsenic which is coming from pesticides and other fertilizers react with calcium in hard water forming calcium arsenate crystals which interrupts renal tissues' antioxidant defense system when get into kidneys.…”

Section: Important Findings On Ckdu In Sri Lanka Over the Yearsmentioning

confidence: 98%

Identification of Social and Occupational Risk Factors Associated with CKDu (Chronic Kidney Disease of Unknown Etiology) Patients Living in an Agricultural Community in Kebithigollewa, Sri Lanka

Lowe¹,

Kumarasinghe²

2021

Int J Nephrol Kidney Fail

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Chronic kidney disease of unknown etiology: Mystery unsolved

Abstract: DOI: http://dx.doi.org/10.4038/jur.v2i1-2.7848J. Univ. Ruhuna 2014 2:1-3

Cited by 4 publications

References 9 publications

Repurposing Approved Drugs for Guiding COVID-19 Prophylaxis: A Systematic Review

Repurposing Approved Drugs for Guiding COVID-19 Prophylaxis: A Systematic Review

Identification of Social and Occupational Risk Factors Associated with CKDu Patients in an Agricultural Community in Kebithigollewa, Sri Lanka

Identification of Social and Occupational Risk Factors Associated with CKDu (Chronic Kidney Disease of Unknown Etiology) Patients Living in an Agricultural Community in Kebithigollewa, Sri Lanka

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