Chronic kidney disease post-liver transplantation

O'Riordan, Aisling; Wong, Vincent Wai‐Sun; McCormick, Peter; Hegarty, John E.; Watson, Alan J.

doi:10.1093/ndt/gfl247

Cited by 100 publications

(95 citation statements)

References 39 publications

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“…1,[5][6][7][8] This wide range is partly explained by a lack of consensus criteria as to what constitutes CKD in these populations and by shortcomings of estimating equations that depend on serum creatinine. 9 Transplant candidates and recipients often have lower muscle mass and less creatinine generation than the populations in which these equations were developed, limiting the accuracy of the equations.…”

Section: Prevalence Of Ckd After Nonrenal Organ Transplantationmentioning

confidence: 99%

“…More recently, using the Kidney Disease Outcomes Quality Initiative (KDOQI) classification system, O'Riordan et al 8 examined the risk for CKD by stage among 230 liver recipients who were followed for a mean of approximately 6 yr. Overall point prevalences of CKD among survivors at 10 yr was 2.26% with stage 5, 6.11% with stage 4, 56.77% with stage 3, 23.71% with stage 2, and the rest with minimal or no renal function deficit.…”

Section: Prevalence Of Ckd After Nonrenal Organ Transplantationmentioning

confidence: 99%

“…101 By conventional criteria, current United Network for Organ Sharing regulations mandate that patients can be listed for kidney transplantation alone only once their estimated GFR is Յ20 ml/min, representing advanced stage 4 CKD. Recognizing that 90% of liver recipients will have some degree of CKD after transplantation, 8 our institutional practice has been to restrict SLKT to patients who are projected to need listing for a kidney within 12 mo after receiving a liver. Our pretransplantation nephrologic assessment entails a thorough medical record review to (1) establish baseline kidney function, (2) ascertain any evidence of previous reversibility, and (3) determine the duration of kidney injury.…”

Section: Simultaneous Solid-organ Kidney Transplantationmentioning

confidence: 99%

See 2 more Smart Citations

Chronic Kidney Disease after Nonrenal Solid-Organ Transplantation

Bloom

Reese

2007

Journal of the American Society of Nephrology

164

138

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Section: Prevalence Of Ckd After Nonrenal Organ Transplantationmentioning

confidence: 99%

Section: Prevalence Of Ckd After Nonrenal Organ Transplantationmentioning

confidence: 99%

Section: Simultaneous Solid-organ Kidney Transplantationmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Kidney Disease after Nonrenal Solid-Organ Transplantation

Bloom

Reese

2007

Journal of the American Society of Nephrology

164

138

View full text Add to dashboard Cite

“…19 On the other hand, the female gender has been identified by other authors as more commonly associated with CKD post-LT than males. 2,20,22,23 These non-modifiable factors should be used to help identify patients at higher risk of CKD in our population of post-LT patients.…”

Section: B Discussionmentioning

confidence: 99%

Early serum tacrolimus levels predict long-term chronic kidney disease after liver transplantation

Brandão¹,

Faria²,

Bicalho³

et al. 2014

Medical Express

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OBJECTIVE: To investigate risk factors for the development of chronic kidney disease and death two years postliver transplantation. METHOD: Associations between clinical and laboratory parameters and the development of chronic kidney disease and survival two years post-liver transplant were analyzed in a cohort of 148 adult patients with hepatic cirrhosis consecutively submitted to liver transplantation in a referral Brazilian center. RESULTS: Median age at liver transplantation was 56 (range, 20-73) years, and 105 (70.9%) patients were males. The prevalence of chronic kidney disease at two years post-liver transplantation was: stage 1 or no chronic kidney disease, 27.5%; stage 2, 33.8%; stage 3, 34.6%; stages 4-5, 4.7%. Four variables were independently associated with the stage of chronic kidney disease two years after liver transplantation: (i) age (at liver transplantation), (ii) male gender, (iii) median tacrolimus levels in the first three months post-liver transplantation, and (iv) median of serum creatinine in the first six months post-liver transplantation. Two variables showed independent association with death in two years post-liver transplantation: (i) stay in Intensive Care Unit for three or more days after the liver transplantation surgery and (ii) median of serum creatinine levels in the first six months postliver transplantation equal or higher than 1.3 mg/dL. CONCLUSIONS: Administration of the lowest effective dose of tacrolimus and adoption of strategies to spare renal function are important measures to reduce the risk of late chronic kidney disease and death post-liver transplantation especially in high risk patients.

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“…8 Importantly, several series have shown that liver transplant recipients who develop chronic renal failure have worse outcomes than those who do not. [8][9][10] Kidney biopsy samples from liver transplant recipients with impaired renal function in the long term have shown that interstitial fibrosis and glomerular sclerosis may each be present in 45%. 11 Calcineurin inhibitor (CNI)-induced arteriolopathy may also be present in approximately 45% of these patients 5 years after transplantation.…”

Section: Continuing Burden Of Impaired Renal Function After Liver Tramentioning

confidence: 99%