Chronic Kidney Disease Progression in Elderly Iranian Patients: a Cohort Study

Shojamoradi, Mohammad Hossein; Isfeedvajani, Mohsen Saberi; Mahdavi‐Mazdeh, Mitra; Ahmadi, Farrokhlagha; Gatmiri, Seyed Mansour; Larki, Rozina Abbasi

doi:10.5812/numonthly.20748

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…In a 3.322 adults patients cohort, 13% of the patients that declined kidney function 77% were elderly [8]. However, like ours, other studies [8, 13, 17] showed that the eGFR slope and its magnitude were higher in younger patients. A possible explanation for that, suggested by O´Hare et al, [18] is the competing risk for death over end renal stage kidney disease present in the elderly population.…”

Section: Discussionsupporting

confidence: 45%

Associated factors related to chronic kidney disease progression in elderly patients

et al. 2019

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Background Chronic Kidney Disease (CKD) is a worldwide public health problem. The prevalence of CKD is rising especially in elderly, as consequence of population-ageing related to socioeconomic development and better life expectancy. There are scarce studies evaluating CKD progression and its associated factors in elderly patients. Methods This is a retrospective observational study including 340 patients (≥ 65 years old) CKD stages 3a–5 non-dialysis, incidents in an outpatient CKD clinic, followed by 2.1 years. CKD progression was assessed by the slope of eGFR calculated by CKD-EPI and BIS 1 equations. The patients were divided in progressor and non-progressor groups (eGFR slope < or ≥ 0 mL/min/1.73 m 2 /year, respectively). Results Kidney function declined in 193 (57%) patients. In this group, the progression rate was -2.83 (-5.1 / -1.1) mL /min /1.73 m 2 /year. Compared to non progressor, the progressor patients were younger [72 (69–78) vs. 76 (69–80) years; p = 0.02]; had higher proportion of diabetic nephropathy, higher serum phosphorus [3.8 (3.3–4.1) vs. 3.5 (3.9–4.1) mg/dL; p = 0.04] and proteinuria [0.10 (0–0.9 vs. 0 (0–0.3)] g/L; p = 0.007)] at the admission. In the logistic regression analysis adjusted for gender and eGFR, proteinuria was independently associated with CKD progression [OR (Odds Ratio) (1.83; 95% CI, 1.17–2.86; p < 0.01)]. Conclusion CKD progression was observed in the majority of elderly CKD patients and proteinuria was the most important factor associated to the decline of kidney function in this population.

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Section: Discussionsupporting

confidence: 45%

Associated factors related to chronic kidney disease progression in elderly patients

et al. 2019

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“…Aunque la relación de la edad avanzada con la aparición y la mayor progresión de la ERC se ha encontrado de manera sistemática en otros estudios [16,17], otros reportes, al igual que este, han mostrado que la pérdida de TFG es mayor en los pacientes más jóvenes [18,19]. O'Hare et al [20] han aportado una posible explicación para este hallazgo y es el riesgo competitivo de la muerte sobre la llegada a enfermedad renal terminal presente en la población mayor.…”

Section: Discussionunclassified

Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean Coast

Pereira-Morales,

Buelvas,

De la Espriella

et al. 2023

Rev. Colomb. Nefrol.

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Background: Chronic Kidney Disease (CKD) is a global public health problem with increasing prevalence and a substantial burden on healthcare systems. The characteristics of rapid progressors and factors that may predict accelerated CKD progression require further exploration, especially since there are no published studies about this topic in Colombia. Purpose: To identify the clinical and sociodemographic factors associated with the rapid progression of CKD in a large cohort of Colombian patients. Methods: This retrospective observational study included two cohorts of G1 to G4 stage CKD patients without dialysis from the Colombian North Coast. Follow-up was conducted for 18 months (n=14,420) and 24 months (n=10,042). Patients were divided into rapid progressors and stable progressors based on the glomerular filtration rate (GFR) slope <?5 mL/min/1.73m2/year or ?-5 mL/min/1.73 m2/year, respectively. Results: 37.68% of the cohort was classified as rapid progressors at 24 months and 28.41% at 18 months. An R2=0.77 was found in both cohorts for GFR measurements, indicating a linear trend toward loss. Furthermore, accelerated progression was observed in younger patients and those with higher diastolic blood pressure values. Conclusion: In two large cohorts of renal patients, approximately 4 out of 10 patients were classified as rapid progressors at 24 months of follow-up and 3 out of 10 at 18 months of follow-up. It is important to identify patients at higher risk of accelerated CKD progression in the short term to provide them with personalized and effective care.

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“…According to the report provided by the National Organization for Civil Registration of Iran, 2,243,249 individuals were referred to all health-care centers in Isfahan from 2017 to 2019. The sample size of this study included 3374 individuals that were selected from the mentioned population at 95% confidence interval, the test power of 80%, and considering the prevalence of CKD reported in recent studies[ 4 ] conducted in our country equal to 6%, and the error level of 0.008.…”

Section: Methodsmentioning

confidence: 99%

“…Considering that the progression of CKD can be prevented by controlling some modifiable risk factors such as blood pressure, cardiovascular events, blood sugar, nephrotoxic drugs, obesity, and salt intake,[ 4 5 6 ] it seems essential to pay due attention to the potential risk factors in this regard to prevent the development of CKD. In this regard, excessive or prolonged alcohol consumption as one of the most common psychedelics in the world is considered a potential risk factor for cardiovascular diseases such as hypertension (HTN) and cerebrovascular accidents.…”

Section: Introductionmentioning

confidence: 99%

Association of alcohol consumption with the prevalence and various stages of chronic kidney disease

Vahdat

Moeinzadeh

Shahidi

et al. 2023

Journal of Research in Medical Sciences

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Background: Considering that the effect of alcohol consumption trend on the prevalence of kidney damage and its progression has not been determined yet, the study aimed at investigating the association between alcohol consumption and the risk of chronic kidney disease (CKD) prevalence and progression at various stages of the disease. Materials and Methods: This cross-sectional study was performed on 3374 participants that referred to health-care centers in Isfahan from 2017 to 2019. Participants' basic and clinical characteristics (such as sex, age, education level, marital status, body mass index, blood pressure, alcohol consumption, comorbidities, and laboratory parameters) were evaluated and recorded. The alcohol consumption trend was classified as never, occasional (<6 drinks/week), and frequent (≥6 drinks/week) based on the amount of alcohol consumption over the last 3 months. Moreover, CKD stages were recorded based on the Kidney Disease: Improving Global Outcomes guideline, as well. Results: In the present study, the occasional and frequent drinking of alcohol did not have a significant effect on the odds of CKD prevalence (odds ratio [OR]: 1.32 and 0.54; P > 0.05) and the odds of stage 2 CKD prevalence as compared to stage 1 CKD prevalence (OR: 0.93 and 0.47; P > 0.05). However, adjusting the confounding factors revealed that occasional drinking as compared to nondrinking increased the odds of stage 3 and 4 CKD prevalence as compared to stage 1 CKD prevalence by 3.35 folds, respectively ( P < 0.05). Conclusion: According to the results of this study, occasional drinking as compared to nondrinking significantly increased the odds of stage 3 and 4 CKD prevalence as compared to stage 1 CKD prevalence.

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Chronic Kidney Disease Progression in Elderly Iranian Patients: a Cohort Study

Cited by 6 publications

References 12 publications

Associated factors related to chronic kidney disease progression in elderly patients

Associated factors related to chronic kidney disease progression in elderly patients

Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean Coast

Association of alcohol consumption with the prevalence and various stages of chronic kidney disease

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