Chronic laminitis: current treatment strategies

Parks, A. H.; O'Grady, Stephen E.

doi:10.1016/s0749-0739(03)00019-1

Cited by 28 publications

(32 citation statements)

References 11 publications

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“…The goal of laminitis pain therapy should be to strike the best possible balance in the spectrum spanning from the maladaptive to the adaptive components of pain and thus require an individualised approach. A modest reduction from high pain levels is probably safe provided that other aspects of the disease are being adequately monitored and managed . On average, the level of improvement obtained with t ‐TUCB in the laminitic horses of the current study is consistent with this notion.…”

Section: Discussionsupporting

confidence: 81%

Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis

Guedes

Galuppo

Hood³

et al. 2016

Equine Veterinary Journal

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Summary Background The roles of soluble epoxide hydrolase and lipid mediators in inflammatory and neuropathic pain could be relevant in laminitis pain management. Objectives To determine soluble epoxide hydrolase (sEH) activity in the digital laminae, sEH inhibitor potency in vitro, and efficacy of a sEH inhibitor as an adjunct analgesic therapy in chronic laminitic horses. Study design In vitro experiments and in vivo case series. Methods sEH activity was measured in digital laminae from euthanized healthy and laminitic horses (n=5–6/group). Potency of seven synthetic sEH inhibitors was determined in vitro using equine liver cytosol. One of them (t-TUCB; 0.1 mg/kg bwt IV every 24 hours) was selected based on potency and stability, and used as adjunct therapy in 10 horses with severe chronic laminitis (Obel grades 2, 1 horse; 3–4, 9 horses). Daily assessments of forelimb lifts, pain scores, physiologic and laboratory examinations were performed before (baseline) and during t-TUCB treatment. Data are presented as mean±SD and 95% confidence intervals (CI). Results sEH activity in the digital laminae from laminitic horses (0.9±0.6 nmol/min/mg; CI: 0.16–1.55 nmol/min/mg) was significantly higher (P=0.01) than in healthy horses (0.17±0.09 nmol/min/mg; CI: 0.07–0.26 nmol/min/mg). t-TUCB as an adjunct analgesic up to 10 days (4.3±3 days) in laminitic horses was associated with significant reduction in forelimb lifts (36 ± 22%; CI: 9–64%) and in pain scores (18±23%; CI: 2–35%) compared to baseline (P=0.04). One horse developed gas colic and another corneal vascularization in a blind eye during treatment. No other significant changes were observed. Main Limitations Absence of control group and evaluator blinding in case series. Conclusions sEH activity is significantly higher in the digital laminae of actively laminitic compared to healthy horses, and use of a potent inhibitor of equine sEH as adjunct analgesic therapy appears to decrease signs of pathologic pain in laminitic horses.

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Section: Discussionsupporting

confidence: 81%

Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis

Guedes

Galuppo

Hood³

et al. 2016

Equine Veterinary Journal

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“…As soon as it is noted radiologically, and the dorsal surface of the distal phalanx and hoof wall are no longer parallel and in line with the other phalanges, the horse has by definition entered the chronic phase of laminitis. The terms capsular rotation and phalangeal rotation are also used to further define the type of dorsal rotation (Parks and O'Grady ).…”

Section: Radiological Interpretation Of the Forefeet In The Laminiticmentioning

confidence: 99%

“…It is also of note that treatment of distal displacement of the distal phalanx varies from treatment of dorsally rotated horses. Horses with distal displacement generally require longer periods of medical management and surgical intervention is seldom indicated (Parks and O'Grady ).…”

Section: Radiological Signs Of Laminitis As Prognostic Indicatorsmentioning

confidence: 99%

Radiographic and radiological assessment of laminitis

Sherlock

Parks

2013

Equine Veterinary Education

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Summary Radiographic studies are an essential component in evaluation of horses with laminitis. The standard radiographs that should be obtained to aid assessment of horses with laminitis are the lateromedial, horizontal dorsopalmar and dorsal 45° proximal palmarodistal oblique views. This article will summarise the assessment of these 3 projections in the laminitic horse as well as discuss the prognostic significance of common radiological abnormalities in horses with laminitis.

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“…The main treatments are the trimming and horseshoes application and similar appliances, and there are questionable effectiveness techniques, especially by individual response and different degrees of involvement hoof (PARKS & O'GRADY, 2003;MORRISON, 2010). The objectives of these practices are to stabilize the phalanx, reduce the pain and stimulate new hoof growth.…”

Section: Treatmentmentioning

confidence: 99%