Chronic light deprivation induces different effects on spatial and fear memory and hippocampal BDNF/TRKB expression during light and dark phases of rat diurnal rhythm

Asadian, Nader; Parsaie, Houman; Vafaei, Abbas Ali; Dadkhah, Masoomeh; Omoumi, Samira; Sedaghat, Katayoun

doi:10.1016/j.bbr.2021.113638

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…These areas show a strong daily rhythm in their activity [17][18][19][20]. In the striatum, the expression levels of BDNF-TrkB pathway exhibit a circadian rhythm, and contributes to the pathogenesis of anxiety and depression [21][22][23][24]. Thus, we hypothesized that dysfunction in the suprachiasmatic nucleus, which affects the circadian rhythm, can induce anxiety-and depression-like behaviors via the BDNF-TrkB pathway in the striatum.…”

Section: Introductionmentioning

confidence: 99%

Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum

Xie,

Ding

et al. 2024

Preprint

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The circadian rhythm system consists of a master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks dispersed throughout other brain areas (including striatum, Str) as well as various tissues and organs. Circadian rhythm disturbance is a major risk factor and common comorbidity for mood disorders, especially anxiety and depression. Bmal1 is one of the fundamental clock protein genes that is required to maintain circadian rhythm. Recent research has revealed a link between suprachiasmatic nucleus dysfunction and anxiety and depression, but the underlying mechanisms remain to be fully elucidated. This study aimed to investigate how circadian rhythm disturbance may lead to anxiety and depression-like behaviors. Through behavioral tests, virus tracing, molecular biology and other techniques, we found neural connection from the suprachiasmatic nucleus to the striatum. SCN lesions and Bmal1flox/flox+pAAV-hSyn-Cre-GFP (conditional knockout, cKO) mice exhibited disruptions in core body temperature rhythm, as well as anxiety- and depression-like behaviors. Importantly, these mice displayed altered expression patterns of clock protein genes and an upregulation of the Brain-Derived Neurotrophic Factor (BDNF) - Tyrosine Kinase receptor B (TrkB) signaling pathway within the striatum. Microinjection of the TrkB inhibitor ANA-12 can effectively reverse anxiety and depression-like behaviors. These findings indicate that suprachiasmatic nucleus dysfunction may contribute to the pathogenesis of anxiety and depression through upregulation of the BDNF-TrkB pathway in the striatum, potentially mediated by neural projections from the SCN. Bmal1 gene within SCN may represent a novel therapeutic target for mood disorders.

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Section: Introductionmentioning

confidence: 99%

Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum

Xie,

Ding

et al. 2024

Preprint

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“…PFC and hippocampus are vital in controlling behaviour, including anxiety and depression‐like behaviour (Albrecht & Stork, 2017; Cha et al, 2016; Hare & Duman, 2020; Snider et al, 2018). For example, altering the standard light–dark cycle for an extended period of time may lead to changes in behaviour, brain function and physiological processes (Asadian et al, 2022; Bedrosian et al, 2013; Tapia‐Osorio et al, 2013; Vandewalle et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of constant darkness on behaviour and physiology of male and female mice

Singh

Pandey

Ghosh

et al. 2023

Eur J of Neuroscience

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A healthy state of life suggests not only a disease-free condition but also normal psychological functioning and behaviour. To maintain a healthy life, the duration of light exposure is a crucial factor. Perturbation of the standard light-dark cycle (LD: 12 h light-12 h dark in mice) may result in brain, behavioural and physiological abnormalities. The current study determined the effects of 3 and 5 weeks of constant darkness (DD: 00 h light-24 h dark) on the behaviour, hormones, prefrontal cortex (PFC) and metabolome of male and female C57BL/6 J mice. We also studied 3 weeks of restoration in LD following 5 weeks of DD exposure. The results revealed that 3 weeks of DD affected male mice more than females, and 5 weeks of DD had a comparable impact on behaviour, hormones and the PFC of male and female mice. After restoration in LD, the DD-induced changes reverted to time-matched LD conditions in male and female mice. Furthermore, metabolome analysis corroborated male and female mice's behavioural and molecular kinetics. The present study laid the foundation for understanding how DD affects behaviour and the PFC as a function of (a) time and (b) sex and described the roles of stress and sex hormones, cytokines, neurotrophins and metabolic pathways.

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Photobiomodulation therapy mitigates depressive-like behaviors by remodeling synaptic links and mitochondrial function

Chen,

Shi,

Liu

et al. 2024

Journal of Photochemistry and Photobiology B: Biology

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Chronic light deprivation induces different effects on spatial and fear memory and hippocampal BDNF/TRKB expression during light and dark phases of rat diurnal rhythm

Cited by 7 publications

References 33 publications

Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum

Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum

Effects of constant darkness on behaviour and physiology of male and female mice

Photobiomodulation therapy mitigates depressive-like behaviors by remodeling synaptic links and mitochondrial function

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