2000
DOI: 10.1016/s0006-8993(00)02797-9
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Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain

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Cited by 155 publications
(92 citation statements)
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“…41,42 The confirmation of this result adds confidence to the validity of our technical approach and analysis.…”
Section: Post-mortem Brain Tissue Analysissupporting
confidence: 62%
See 2 more Smart Citations
“…41,42 The confirmation of this result adds confidence to the validity of our technical approach and analysis.…”
Section: Post-mortem Brain Tissue Analysissupporting
confidence: 62%
“…53,54 Decreased creatine levels have previously been observed in rat brain after a short treatment course of mood stabilizers. 42 However, a second study with a short treatment course found creatine to be unchanged, but also failed to identify myo-inositol depletion after lithium treatment. 55 This is the first report to show creatine decreasing after long-term treatment with mood-stabilizing medications.…”
Section: Post-mortem Brain Tissue Analysismentioning
confidence: 99%
See 1 more Smart Citation
“…Among those, inhibition of the inositol monophosphatase was suggested to be a common mechanism of action of three mood stabilizers (Williams et al, 2002). Inhibition of the inositol monophosphatase has been shown to increase inositol monophosphates and to decrease myoinositol concentrations in rat brain (O'Donnell et al, 2000), although in humans, this effect has not consistently been observed (Silverstone et al, 2005). In our study, chronic lithium treatment did not result in significant changes in the levels of those inositol phosphates that have specific roles in cell signalling (Table 3 and Figure 5a).…”
Section: Discussionmentioning
confidence: 99%
“…8,17,18 A number of 1 H MRS studies have demonstrated reduced NAA levels in patients with bipolar disorder compared to normal controls 2,5,[19][20][21] (Table 1). Although the use of Cr as a reference peak has been criticized due to observations of alterations in this signal following treatment with lithium and/or sodium valproate, 22 findings of decreased NAA/ Cr þ PCr ratios in bipolar subjects have been corroborated by observations of similarly significant reductions in NAA levels measured relative to voxel H 2 O levels. 5,19 Furthermore, a number of studies have noted negative correlations between NAA/Cr þ PCr or NAA levels and illness duration, 2,5,20 which implies that reductions in NAA levels in bipolar subjects may become more pronounced with time.…”
mentioning
confidence: 99%