Chronic low-dose glucocorticoid treatment increases subcutaneous abdominal fat, but not visceral fat, of male Wistar rats

Nunes, Pedro Murilo Sales; Andreotti, Sandra; Silva, Flaviane de Fatima; Sertié, Rogério Antônio Laurato; Caminhotto, Rennan de Oliveira; Komino, Ayumi Cristina Medeiros; Reis, Gabriela Boltes; Lima, Fábio Bessa

doi:10.1016/j.lfs.2017.09.030

Cited by 6 publications

(6 citation statements)

References 34 publications

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“…However, in both in vivo studies, these results were not compared to those in subcutaneous WAT. Others have demonstrated that there are differential sensitivities of subcutaneous and visceral depots in rats treated with high or low doses of corticoids ( Nunes et al, 2017 ). At low doses, only subcutaneous fat depots had increased their lipid storage capability and activity of lipid synthesising enzymes while these parameters were increased in visceral fat at high doses ( Nunes et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…Others have demonstrated that there are differential sensitivities of subcutaneous and visceral depots in rats treated with high or low doses of corticoids ( Nunes et al, 2017 ). At low doses, only subcutaneous fat depots had increased their lipid storage capability and activity of lipid synthesising enzymes while these parameters were increased in visceral fat at high doses ( Nunes et al, 2017 ). Another study confirmed genetic and metabolic differences between subcutaneous and visceral locations at the level of the corresponding adipose-derived stem cells using gene expression analysis ( Kim et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

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Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate

Ishaq

Tchkonia

Kirkland

et al. 2022

Experimental Gerontology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate

Ishaq

Tchkonia

Kirkland

et al. 2022

Experimental Gerontology

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“…[49][50][51] In addition, it is also known that glucocorticoid-induced redistribution in adipose tissue may be considered a form of iatrogenic lipodystrophy. It is well known that oral glucocorticoids drugs are associated with abnormal deposits in abdominal subcutaneous adipose tissue, and a recent experimental study showed that, even at chronic low-doses, this pattern occurs.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that oral glucocorticoids drugs are associated with abnormal deposits in abdominal subcutaneous adipose tissue, and a recent experimental study showed that, even at chronic low-doses, this pattern occurs. [49][50][51] In addition, it is also known that glucocorticoid-induced redistribution in adipose tissue may be considered a form of iatrogenic lipodystrophy. 52 According to Pickering by which dexamethasone could promote the preferential storage of fat in visceral deposits.…”

Section: Considering This Difference Between Groups and The Differencmentioning

confidence: 99%

High abdominal adiposity and low phase angle in overweight renal transplant recipients

Ferreira

Silva

Costa

et al. 2019

Clinical Transplantation

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Obesity is associated with increased risk of cardiovascular disease (CVD). Body mass index (BMI) is the most used parameter for obesity screening. However, the evaluation of CVD risk in overweight individuals should include the assessment of body fat distribution and body composition. Renal transplant recipients (RTR) have a high CVD risk and frequently present weight gain and loss of lean mass. The aim of this study was to evaluate body fat distribution and body composition in overweight RTR. This cross‐sectional study was conducted with 86 RTR and 86 hypertensive individuals (comparison group, CG) presenting BMI 25‐35 Kg/m2 and 45‐70 years. Anthropometric evaluation included BMI, waist circumference, waist‐to‐height ratio, and a body shape index. Body composition was evaluated with bioelectrical impedance analysis (BIA). Glomerular filtration rate was estimated (eGFR) by CKD‐EPI equation. RTR group (RTRG) and CG presented similar age and BMI. RTRG when compared to CG presented lower percentage of women and eGFR; higher central adiposity; and lower values of reactance, intracellular water, body cell mass and phase angle, more consistently observed in women. This study suggests that overweight RTR present higher abdominal adiposity and impairment in BIA parameters that are sensitive indicators of impaired membrane integrity, water distribution, and body cell mass.

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“…At high doses, GCs increase lipolysis, antagonize the lipolytic effect of insulin, and increase appetite. GCs increase protein synthesis in the liver but inhibit it in other tissues (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Various Doses of Prednisolone Administration on Serum Vaspin Levels in Rats

et al. 2018

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Aim. The aim of this study was to investigate the dose-dependent effects of prednisolone administration on serum vaspin levels and correlate this with changes in the BMI and lipogenesis in rats.Materials and Methods. Twenty-four albino Wistar male rats weighing between 190-240 g were divided into four groups, three experimental (5 mg/kg, 10 mg/kg, and 20 mg/kg prednisolone) and one control. The prednisolone groups were given once-daily doses for 30 days, orally. In addition, the rats were weighed, and their height and waist circumferences were measured once a week. At the end of 30 days, vaspin and glucose levels were measured from blood samples.Results. In the prednisolone groups, the vaspin levels significantly increased when compared with the control group. The control group has a serum vaspin level of 155 ± 20.99 pg/mL and this level has been increased by prednisolone administration in a dose dependent manner. In the prednisolone groups, especially the 10 mg/kg and 20 mg/ kg groups, the glucose levels increased in a dose dependent fashion. Conclusion.Prednisolone administration significantly increased serum glucose and vaspin levels in a dose dependent manner, indicating that the increase in the serum vaspin levels could be related to the increase in the serum glucose concentration. Vaspin can be a molecule that is released in response to increased glucose and can be a rebound defense mechanism to modulate the blood glucose concentration. We suggest vaspin as a potential target for the treatment and diagnosis of diabetes mellitus and other metabolic disorders.

show abstract

Chronic low-dose glucocorticoid treatment increases subcutaneous abdominal fat, but not visceral fat, of male Wistar rats

Cited by 6 publications

References 34 publications

Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate

Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate

High abdominal adiposity and low phase angle in overweight renal transplant recipients

The Effects of Various Doses of Prednisolone Administration on Serum Vaspin Levels in Rats

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