Chronic low-grade inflammation in polycystic ovary syndrome: is there a (patho)-physiological role for interleukin-1?

Popović, Milica; Sartorius, Gideon

doi:10.1007/s00281-019-00737-4

Cited by 58 publications

(50 citation statements)

References 102 publications

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“…In recent years, some studies reported that this process could be stimulated by the pro-inflammatory interleukin-1 (IL-1), which is overexpressed in women with PCOS [50].…”

Section: Discussionmentioning

confidence: 99%

“…Poly-unsaturated fatty acids (PUFAs), the precursors of eicosanoids, were significantly increased in women with PCOS compared with the control subjects, which may be due to the presence of low-grade systemic inflammation. In recent years, some studies reported that this process could be stimulated by the pro-inflammatory interleukin-1 (IL-1), which is overexpressed in women with PCOS [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

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Metabolomic Insight into Polycystic Ovary Syndrome—An Overview

Rajska

Buszewska-Forajta

Rachoń

et al. 2020

IJMS

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Searching for the mechanisms of the polycystic ovary syndrome (PCOS) pathophysiology has become a crucial aspect of research performed in the last decades. However, the pathogenesis of this complex and heterogeneous endocrinopathy remains unknown. Thus, there is a need to investigate the metabolic pathways, which could be involved in the pathophysiology of PCOS and to find the metabolic markers of this disorder. The application of metabolomics gives a promising insight into the research on PCOS. It is a valuable and rapidly expanding tool, enabling the discovery of novel metabolites, which may be the potential biomarkers of several metabolic and endocrine disorders. The utilization of this approach could also improve the process of diagnosis and therefore, make treatment more effective. This review article aims to summarize actual and meaningful metabolomic studies in PCOS and point to the potential biomarkers detected in serum, urine, and follicular fluid of the affected women.

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“…In recent years, some studies reported that this process could be stimulated by the pro-inflammatory interleukin-1 (IL-1), which is overexpressed in women with PCOS [50].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metabolomic Insight into Polycystic Ovary Syndrome—An Overview

Rajska

Buszewska-Forajta

Rachoń

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder commonly found in women of childbearing age. Common clinical criteria include menstrual disorder, infrequent ovulation, chronic anovulation, hirsutism, hyperandrogenism (HA), insulin resistance (IR) and ovarian polycystic changes [1,2]. Currently, the mechanism of PCOS is still under debate.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, the mechanism of PCOS is still under debate. However, it is acknowledged that low-grade inflammation and IR are involved in the pathological process of PCOS [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

PCOS without hyperandrogenism is associated with higher plasma Trimethylamine N-oxide levels

et al. 2020

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Background: Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder, and its pathogenesis is still under debate. Trimethylamine-N-oxide (TMAO) is a small, organic compound generated by the gut microbiome with a hypothesized relation to insulin resistance (IR) and low-grade inflammation in PCOS. By comparing plasma TMAO levels in non-PCOS participants and PCOS patients without hyperandrogenism (HA), we aimed to determine whether plasma TMAO levels correlate with PCOS without HA and to analyze their relationship with low-grade inflammation and IR. Methods: A total of 27 PCOS patients without HA and 23 non-PCOS participants were enrolled in this study and subdivided into "nonobese" and "obese" arms for each group. Levels of plasma TMAO were quantified, and basic clinical characteristics and plasma biomarkers of inflammation were assessed. Results: First, plasma TMAO levels, insulin levels and homeostatic model assessment of insulin resistance (HOMA-IR) values were higher in PCOS patients without HA, especially in the obese subgroup. Second, the levels of the inflammatory factors interleukin (IL)-17A, IL-18 and interferon gamma (IFN-γ) were significantly increased in obese PCOS patients without HA. Third, plasma TMAO levels were associated with body mass index (BMI) in the normalweight groups, and the obese groups had higher fasting plasma insulin (FINS) and HOMA-IR values. Finally, logistic regression showed that the plasma levels of TMAO and luteinizing hormone/follicle-stimulating hormone (LH/FSH) were independent predictors of PCOS and indicated an increased risk of PCOS. Conclusions: Elevated plasma TMAO levels may be associated with the pathogenesis of PCOS without HA and correlated with increased systemic inflammation. Further studies are needed to determine the suitability of TMAO as a predictive biomarker and to identify possible therapies for PCOS.

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“…Furthermore, several conditions associated with a metabolic syndrome such as rheumatoid arthritis are driven by the innate system and may benefit from targeted anti-inflammatory treatment [8]. This may be the case for the pathogenesis of polycystic ovary syndrome, as proposed in the original contribution of Popovic and co-authors [12]. Understanding the role of inflammation and of the gut microbiome in type 2 diabetes may also provide an explanation for the impressive benefit of bariatric surgery in metabolism.…”

mentioning

confidence: 99%

Inflammation and type 2 diabetes: from basic science to treatment

Donath

2019

Semin Immunopathol

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Chronic low-grade inflammation in polycystic ovary syndrome: is there a (patho)-physiological role for interleukin-1?

Cited by 58 publications

References 102 publications

Metabolomic Insight into Polycystic Ovary Syndrome—An Overview

Metabolomic Insight into Polycystic Ovary Syndrome—An Overview

PCOS without hyperandrogenism is associated with higher plasma Trimethylamine N-oxide levels

Inflammation and type 2 diabetes: from basic science to treatment

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