Chronic lung disease of the newborn is not associated with <i>Ureaplasma urealyticum</i>

Ollikainen, Jukka; Korppi, Matti; Heiskanen‐Kosma, Tarja; Heinonen, Kirsti

doi:10.1002/ppul.1123

Cited by 35 publications

(8 citation statements)

References 30 publications

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“…Studies in infants with mean birth weights of 827-1000 g demonstrated OR of 2.0 -3.8 (24,26 -28), yet in studies of larger infants (975-1300 g) there was no association detected between Ureaplasma sp. and BPD (14,33,35). This ambiguity may be related to the difference in size, as smaller, more gestationally immature infants are at higher risk of BPD.…”

Section: Discussionmentioning

confidence: 99%

Detection of Ureaplasma DNA in Endotracheal Samples Is Associated With Bronchopulmonary Dysplasia After Adjustment for Multiple Risk Factors

et al. 2007

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Microorganisms are hypothesized to contribute to the pathogenesis of bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW) infants. This hypothesis remains controversial. We sought to determine whether endotracheal colonization with Ureaplasma sp., adenovirus, or Chlamydia sp. increases the risk of BPD. Intubated VLBW infants were included. Polymerase chain reaction (PCR) analysis was used to detect Ureaplasma sp., adenovirus, and Chlamydia sp. The outcome measure was BPD or death due to lung disease. Detection of microorganisms was compared between subjects with and without BPD. Logistic regression was used to control for covariates. Of 139 subjects, 33 (25%) screened positive for Ureaplasma sp., 22 of 136 (16%) were positive for adenovirus; eight of 133 (6%) were positive for Chlamydia sp. At 36 wk postmenstrual age, 14 patients had died, 68 (57%) had BPD. Detection of Ureaplasma sp. was associated with BPD or death (p < 0.001); adenovirus (p = 0.52) and Chlamydia sp. (p = 0.33) were not. Controlling confounding factors, the odds ratio for Ureaplasma sp. and BPD or death was 4.2 (95% CI 1.03, 17). In our population, detection of Ureaplasma sp., but not adenovirus or Chlamydia sp. was associated with BPD or death due to lung disease.

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Section: Discussionmentioning

confidence: 99%

Detection of Ureaplasma DNA in Endotracheal Samples Is Associated With Bronchopulmonary Dysplasia After Adjustment for Multiple Risk Factors

et al. 2007

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“…The studies were also grouped by definition of BPD, oxygen requirement at 28 days postnatal age (BPD28) and/or 36 weeks postmenstrual age (BPD36). Twenty-three articles reported Ureaplasma colonization and BPD28 (2,6,7,13,45,49,62,89,109,111,123,128,134,137,208,209,215,216,241,247,250,307,329) and eight reported BPD36 (49, 89, 109, 111, 127, 208, 209, 216). There were 2216 infants included in the BPD28 group and 751 infants in the BPD36 group.…”

Section: Association Of Ureaplasma Spp With Development Of Chronic Lmentioning

confidence: 99%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

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SUMMARY The genital mycoplasmas represent a complex and unique group of microorganisms that have been associated with a wide array of infectious diseases in adults and infants. The lack of conclusive knowledge regarding the pathogenic potential of Mycoplasma and Ureaplasma spp. in many conditions is due to a general unfamiliarity of physicians and microbiology laboratories with their fastidious growth requirements, leading to difficulty in their detection; their high prevalence in healthy persons; the poor design of research studies attempting to base association with disease on the mere presence of the organisms in the lower urogenital tract; the failure to consider multifactorial aspects of diseases; and considering these genital mycoplasmas only as a last resort. The situation is now changing because of a greater appreciation of the genital mycoplasmas as perinatal pathogens and improvements in laboratory detection, particularly with regard to the development of powerful molecular nucleic acid amplification tests. This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to mycoplasma and ureaplasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.

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“…Meta‐analysis by Wang et al in 1995 found a significant association between U. urealyticum colonization and subsequent development of CLD 2 . Since then the association of CLD and U. urealyticum has been an issue for discussion and is still controversial 3–13 . This may be due to the different definitions of CLD used in varied studies, with differences including patient selection or sites and the time of sampling for the culture.…”

mentioning

confidence: 99%

Certain type of chronic lung disease of newborns is associated with Ureaplasma urealyticum infection in utero

Honma

Yada

Takahashi

et al. 2007

Pediatrics International

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Chronic lung disease of the newborn is not associated with Ureaplasma urealyticum

Cited by 35 publications

References 30 publications

Detection of Ureaplasma DNA in Endotracheal Samples Is Associated With Bronchopulmonary Dysplasia After Adjustment for Multiple Risk Factors

Detection of Ureaplasma DNA in Endotracheal Samples Is Associated With Bronchopulmonary Dysplasia After Adjustment for Multiple Risk Factors

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Certain type of chronic lung disease of newborns is associated with Ureaplasma urealyticum infection in utero

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