Chronic lymphocytic leukaemia is a risk factor for venous thromboembolism

Venous and arterial thrombosis in patients with haematological malignancy during treatment with ibrutinib

“…Our data supported that, in patients treated with ibrutinib, the rate of thrombosis was low (3·9%) and the cumulative incidence of VTE was lower than expected as compared to historical controls (0·6 per 100 person‐years in our study compared to 1·5 per 100 person‐years in prior studies of CLL patients) (Whittle et al , ; Simkovic et al , )’. However, many patients in our study received concomitant antiplatelet agents or AC (39·6% and 8·3%, respectively), which may have reduced the risk of thrombosis even though the median overlap was short.…”

Risk of Venous Thromboembolism in Patients with Cancer: A Systematic Review and Meta-Analysis

“…Of the 38 cohorts, 31 were categorised as high risk and seven were categorised as average risk because they were judged to be representative of all patients with a cancer diagnosis [30],[33],[36],[40],[57],[61],[64]. Studies were classed as high risk when follow-up commenced following outpatient chemotherapy ( n  = 9), surgery ( n  = 8), inpatient hospitalisation (not specifically for surgery, n  = 2), or a receipt of a mixture of treatment types ( n  = 7), or because either all or the majority of patients had advanced or metastatic cancer at baseline ( n  = 5).…”

Paraneoplastic Pemphigus in A Patient with Chronic Lymphocytic Leukemia: A Case Report

“…Recent reports have shown that the major reasons for mortality in PNP cases are sepsis, progression of malignancies and respiratory failure [1,7,10]. Venous thromboembolism is one of the most common causes of morbidity and mortality in cancer patients with incidence of approximately 11% in CLL cases [11]. Hyperleukocytosis may contribute to thrombosis in CLL patients.…”