Chronic Lymphocytic Leukemia in the Colon

Burris, Ashley; Latham, Charles; Bal, Bikram

doi:10.1038/ajg.2014.278

Cited by 3 publications

(2 citation statements)

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“…Ten cohort studies reported 1663 anorectal testing assessments in patients presenting with chronic constipation symptoms. [25][26][27][28][29][30][31][32][33][34] Summary diagnostic accuracy is described in Table 3. The AUC was 0.72 (95% CI 0.66-0.77) with 86% summary sensitivity (95% CI 64-95) and 49% summary specificity (95% CI 30-68) to diagnose dyssynergic defecation using anorectal manometry alone with a diagnostic OR of 6 (95% CI 2-15) (Figure 2A).…”

Section: Estimating Real-world Diagnostic Accuracy Of Anorectal Manometry In Broader Practicementioning

confidence: 99%

“…In combining case-control studies with cohort studies, 15 studies enrolling 2140 patients were included. [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] The AUC was 0.78 (0.72-0.82) with summary sensitivity of 79% (95% CI 61-90) and summary specificity of 64% (95% CI 44-79) in diagnosing dyssynergic defecation, with a diagnostic OR of 6 (95% CI 3-14) (Figure 2B).…”

Section: Estimating Optimal Diagnostic Accuracy Of Anorectal Manometry In Enriched Tertiary Care Populationsmentioning

confidence: 99%

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Anorectal manometry to diagnose dyssynergic defecation: Systematic review and meta‐analysis of diagnostic test accuracy

Ortengren

Ramkissoon

Chey

et al. 2021

Neurogastroenterology Motil

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Background: Chronic constipation is a common condition, and dyssynergic defecation underlies up to 40% of cases. Anorectal manometry is recommended to assess for dyssynergic defecation among chronically constipated patients but remains poorly standardized. We aimed to evaluate the diagnostic accuracy of anorectal manometry and determine optimal testing parameters. Methods:We performed a systematic review with meta-analysis of diagnostic test accuracy including cohort studies of chronically constipated patients and case-control studies of patients with dyssynergic defecation or healthy controls. Meta-analysis was performed to determine summary sensitivity, specificity, and area under the curve (AUC) with 95% confidence intervals (CI).

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Section: Estimating Real-world Diagnostic Accuracy Of Anorectal Manometry In Broader Practicementioning

confidence: 99%

Section: Estimating Optimal Diagnostic Accuracy Of Anorectal Manometry In Enriched Tertiary Care Populationsmentioning

confidence: 99%

Anorectal manometry to diagnose dyssynergic defecation: Systematic review and meta‐analysis of diagnostic test accuracy

Ortengren

Ramkissoon

Chey

et al. 2021

Neurogastroenterology Motil

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Amoxicillin/clavulanic acid

2015

Reactions Weekly

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Previous studies have demonstrated that Nocardia brasiliensis is susceptible to amoxicillin-clavulanic acid and that its I8-lactamases are inhibited in vitro by, clavulanic acid. A cardiac transplant patient with disseminated infection caused by N. brasiliensis was treated with this drug combination with good response, but relapsed while still on therapy. The relapse isolate was found to be identical to the initial isolate by using genomic DNA restriction fragment patterns obtained by pulsed field gel electrophoresis, but it was resistant to amoxicillin-clavulanic acid. On isoelectric focusing, the ,I-lactamase from the relapse isolate exhibited a shift in the isoelectric point (pl) of its major band from 5.10 to 5.04 compared with the enzyme from the pretreatment isolate. As determined by using values of the amount of ,-lactamase inhibitor necessary to give 50 5% inhibition of P-lactamase-mediated hydrolysis of 50 FM nitrocefin, the I8-lactamase of the relapse isolate was also 200-fold more resistant than the enzyme from the pretreatment isolate to clavulanic acid and was more resistant to sulbactam, tazobactam, cloxacillin, and imipenem. The I-lactamase of the relapse isolate exhibited a 10-fold decrease in hydrolytic activity for cephaloridine and other hydrolyzable cephalosporins compared with that for nitrocefin. Acquired resistance to amoxicillin-clavulanic acid in this isolate of N. brasiliensis appears to have resulted from a mutational change affecting the inhibitor and active site(s) in the

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Lubiprostone Is Effective in Treating Functional Bowel Disease With Constipation

Littlehales

Ford

2015

Clinical Gastroenterology and Hepatology

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Chronic Lymphocytic Leukemia in the Colon

Cited by 3 publications

References 0 publications

Anorectal manometry to diagnose dyssynergic defecation: Systematic review and meta‐analysis of diagnostic test accuracy

Anorectal manometry to diagnose dyssynergic defecation: Systematic review and meta‐analysis of diagnostic test accuracy

Amoxicillin/clavulanic acid

Lubiprostone Is Effective in Treating Functional Bowel Disease With Constipation

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