Chronic Manganism: Fourteen Years of Follow-up

Bleich, Stefan; Degner, Detlef; Sprung, R; A, Riegel; Poser, W.; Rüther, Eckart

doi:10.1176/jnp.11.1.117

Cited by 19 publications

(9 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been recommended that for symptomatic treatment, L-dopa or 5-hydroxytryptophan may relieve some Parkinson type of syndromes such as lessened muscular tension during the course of drug application, yet the original signs recurred soon after discontinuation of the drugs. 9 To the best of our knowledge, this group is the first in the literature to demonstrate an effective treatment of severe Mn intoxication in humans by using antibacterial PAS. [18][19][20] More importantly, our 17-year follow-up study reported here clearly shows that PAS treatment not only significantly alleviates clinical symptoms and signs of manganism at the time of treatment, but appears also to have a beneficial prognostic effect.…”

Section: Discussionmentioning

confidence: 99%

“…Patients' symptoms, including disturbed rigor, muscle pain or cramps, sweating, fatigue, and anxiety, may be improved; however, most extrapyramidal syndromes in gait, rigidity, and writing remain unchanged. [9][10][11] Some investigators suggest that clinical progression in patients with manganese parkinsonism can continue even 10 years after cessation of exposure. 11 Recent evidence indicates that Mn intoxication may trigger a neurodegenerative process.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effective Treatment of Manganese-Induced Occupational Parkinsonism With p-Aminosalicylic Acid: A Case of 17-Year Follow-Up Study

Jiang

Mo²,

Feng-qi³

et al. 2006

Journal of Occupational and Environmental Medicine

131

103

View full text Add to dashboard Cite

Objective-Chronic manganese (Mn) intoxication induces syndromes resembling Parkinson disease. The clinical intervention has largely been unsuccessful. We report a 17-year follow-up study of effective treatment of occupational Mn parkinsonism with sodium para-aminosalicylic acid (PAS).Methods-The patient, female and aged 50 at the time of treatment, was exposed to airborne Mn for 21 years . The patient had palpitations, hand tremor, lower limb myalgia, hypermyotonia, and a distinct festinating gait. She received 6 g PAS per day through an intravenous drip infusion for 4 days and rested for 3 days as one therapeutic course. Fifteen such courses were carried out between March and June 1987.Results-At the end of PAS treatment, her symptoms were significantly alleviated, and handwriting recovered to normal. Recent follow-up examination at age 67 years (in 2004) showed a general normal presentation in clinical, neurologic, brain magnetic resonance imaging, and handwriting examinations with a minor yet passable gait.Conclusions-This case study suggests that PAS appears to be an effective drug for treatment of severe chronic Mn poisoning with a promising prognosis.Occupational exposure to manganese (Mn) takes place in ore extraction and processing, steel and alloy production, welding, chemical synthesis, ceramic production, and dry battery fabrication. Mn is also used in water purification, as bactericidal and fungicide agents, and recently used as an antiknock agent in gasoline. Neurotoxicities resulting from occupational

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effective Treatment of Manganese-Induced Occupational Parkinsonism With p-Aminosalicylic Acid: A Case of 17-Year Follow-Up Study

Jiang

Mo²,

Feng-qi³

et al. 2006

Journal of Occupational and Environmental Medicine

131

103

View full text Add to dashboard Cite

show abstract

“…This type of effect may be more likely to occur in the elderly. By the oral route, manganese is often regarded as one of the least toxic elements, although there are several case reports of oral exposure to high doses of manganese that have described neurological impairment as an effect (ATSDR 2000b;Banta and Markesbery 1977;Bleich et al 1999;Holzgraefe et al 1986).…”

Section: Principal Component Analysismentioning

confidence: 99%

Human health risk assessment via drinking water pathway due to metal contamination in the groundwater of Subarnarekha River Basin, India

Giri

Singh

2015

Environ Monit Assess

205

View full text Add to dashboard Cite

Groundwater samples were collected from 30 sampling sites throughout the Subarnarekha River Basin for source apportionment and risk assessment studies. The concentrations of As, Ba, Cd, Cr, Co, Cu, Fe, Mn, Mo, Ni, Se, Sr, V and Zn were determined using inductively coupled plasma-mass spectrometry (ICP-MS). The results demonstrated that concentrations of the metals showed significant spatial variation with some of the metals like As, Mn, Fe, Cu and Se exceeding the drinking water standards at some locations. Principal component analysis (PCA) outcome of four factors that together explained 84.99 % of the variance with >1 initial eigenvalue indicated that both innate and anthropogenic activities are contributing factors as source of metal in groundwater of Subarnarekha River Basin. Risk of metals on human health was then evaluated using hazard quotients (HQ) and cancer risk by ingestion for adult and child, and it was indicated that Mn was the most important pollutant leading to non-carcinogenic concerns. The carcinogenic risk of As for adult and child was within the acceptable cancer risk value of 1 × 10(-4). The largest contributors to chronic risks were Mn, Co and As. Considering the geometric mean concentration of metals, the hazard index (HI) for adult was above unity. Considering all the locations, the HI varied from 0.18 to 11.34 and 0.15 to 9.71 for adult and child, respectively, suggesting that the metals posed hazard by oral intake considering the drinking water pathway.

show abstract

“…Although long‐term overexposure to Mn 2+ has been proven to be detrimental as it leads to Mn poisoning with the brain as a major compromised organ , research regarding the acute influence of systemically administered Mn 2+ on organs of interest is limited. One recent study revealed that subcutaneous use of a single high‐dose MnCl 2 at 500 μmol/kg in rats could lead to mild but detectable neurophysiological and behavioral changes, whereas a single low‐dose administration at 100 μmol/kg did not cause this occurrence, although it did not mention the status of other important organs such as liver, kidneys and heart .…”

Section: Discussionmentioning

confidence: 99%

Dynamic manganese‐enhanced magnetic resonance imaging can detect chronic cryoinjury‐induced infarction in pig hearts in vivo

Yang

Gervai

Sun

et al. 2011

Contrast Media & Molecular

View full text Add to dashboard Cite

The purpose was to investigate whether MnCl2 can serve as an MRI contrast agent to detect chronic cryoinjury infarction in pigs in vivo and whether MnCl2 causes significant hemodynamic disturbances. Hearts were subjected to a topical 2 min cryothermia to establish myocardial infarction (MI). Thereafter GdDTPA‐enhanced MRI was performed at 0, 1, 2 and 3 weeks using a 3 T scanner. Four weeks post‐cryoinjury the pigs underwent in vivo Mn‐enhanced magnetic resonance imaging (MEMRI). MnCl2 (70 μmol/kg, 14 min) was infused i.v. intermittently (n = 4) or continuously (n = 5) and T1‐weighted images were acquired every 2 min simultaneously recording heart rate and arterial blood pressure. Either infusion scheme led to an immediate increment in MR signal intensity (SI) within the left ventricular (LV) blood pool and LV normal and cryoinjured myocardium, which reached a maximum at the end of infusion. No significant difference was observed between the normal and cryoinjured myocardium. After infusion termination, SI decreased faster within the LV blood pool and the MI, as compared with the normal myocardium in either group, resulting in significant contrast between the MI and normal tissue (intermittent: 18 ± 7 vs 49 ± 13%, p = 0.002; continuous: 19 ± 8 vs 36 ± 9%, p = 0.004). Infarction sizes were similar in Mn2+‐ and GdDTPA‐enhanced images at 4 and 3 weeks post injury, respectively. Thus, in vivo MEMRI differentiated infarcted from normal myocardium in pig hearts subjected to 4‐week cryoinjury. Compared with intermittent infusion, continuous infusion minimized hemodynamic fluctuations. Copyright © 2011 National Research Council Canada.

show abstract

Chronic Manganism: Fourteen Years of Follow-up

Cited by 19 publications

References 4 publications

Effective Treatment of Manganese-Induced Occupational Parkinsonism With p-Aminosalicylic Acid: A Case of 17-Year Follow-Up Study

Effective Treatment of Manganese-Induced Occupational Parkinsonism With p-Aminosalicylic Acid: A Case of 17-Year Follow-Up Study

Human health risk assessment via drinking water pathway due to metal contamination in the groundwater of Subarnarekha River Basin, India

Dynamic manganese‐enhanced magnetic resonance imaging can detect chronic cryoinjury‐induced infarction in pig hearts in vivo

Contact Info

Product

Resources

About