2017
DOI: 10.1016/j.jnutbio.2017.01.008
|View full text |Cite
|
Sign up to set email alerts
|

Chronic maternal calcium and 25-hydroxyvitamin D deficiency in Wistar rats programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
9
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 16 publications
(10 citation statements)
references
References 62 publications
1
9
0
Order By: Relevance
“…Low calcium intake during maternal pregnancy and lactation resulted in increased plasma concentrations of TG and TC, and hepatic lipid accumulation in female instead of male. This is consistent with Sharma’s reports showing that chronic maternal calcium deficiency in Wistar rat programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring 38 . Clinical studies demonstrated that calcium intake might have an effect on serum lipid concentrations predominantly in women instead of men 39 , 40 .…”
Section: Discussionsupporting
confidence: 93%
“…Low calcium intake during maternal pregnancy and lactation resulted in increased plasma concentrations of TG and TC, and hepatic lipid accumulation in female instead of male. This is consistent with Sharma’s reports showing that chronic maternal calcium deficiency in Wistar rat programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring 38 . Clinical studies demonstrated that calcium intake might have an effect on serum lipid concentrations predominantly in women instead of men 39 , 40 .…”
Section: Discussionsupporting
confidence: 93%
“…A recent study used a VDD Wistar rat model to explore this area. F1 generation adult (34 weeks old) female offspring exhibited severe hepatic steatosis, abnormal lipid metabolism, increased markers of inflammation and oxidative stress and downregulation of hepatic Ppara and Ucp2 expression (Sharma et al 2017). Interestingly, male F1 offspring were affected to a lesser extent with only mild hepatic steatosis but showed similar downregulation of Ucp2 and the positive regulator of oxidative stress superoxide dismutase 1 (Sod1), demonstrating sex differences.…”
Section: Rodent Modelsmentioning
confidence: 99%
“…Similarly, prenatal vitamin D deficiency is associated with increased insulin resistance and inflammatory mediators in the childhood 74,75 . A study of rat revealed that offspring who were born from mothers under vitamin D deficiency had increased fatty acid and markers of inflammation and oxidative stress in liver and higher prevalence of liver steatosis 76 . In a mouse study, maternal vitamin D deficiency‐induced structural remodeling of pancreas and impaired insulin secretion due to reduced gene expression of PDX‐1, which regulates the expression of GLUT2, glucokinase and insulin in adult offspring 77 .…”
Section: Development Origin Of Health and Diseasementioning
confidence: 99%