Chronic Maxillary Sinusitis Associated with the Mushroom Schizophyllum commune in a Patient with AIDS

Rosenthal, Jonathan; Katz, Rachel; DuBois, Dwight B.; Morrissey, Anne B.; Machicao, Andrea R.

doi:10.1093/clinids/14.1.46

Cited by 65 publications

(36 citation statements)

References 8 publications

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“…125, 0.39, and 12.5 [ig/m\, respectively. Administration ofAMPH-Bwere reported to be effective (8,10). In this case, oral itraconazole (200 mg daily) for one month was ineffective although MICwas within the therapeutic ranges.…”

Section: Discussionmentioning

confidence: 77%

Mucoid Impaction Caused by Monokaryotic Mycelium of Schizophyllum commune in Association with Bronchiectasis.

et al. 2000

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A 51-year-old female was admitted to our hospital because of fever, cough, and hemoptysis. A chest radiograph showed a partial collapse of the left upper division and infected bullae in the left upper lobe. Bronchoscopic examination showed thick mucous plugs in the left upper bronchus. The isolates of the plugs proved to be Schizophyllum commune. Neither accumulation of eosinophils nor Charcot-Leyden crystals were present in the plugs. Mild ectatic changes of the left upper bronchus had been observed 17 years previously. Wedescribe the first case of mucoid impaction, which was independent of the immunological reactions, caused by S. communein association with bronchiectasis.

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Section: Discussionmentioning

confidence: 77%

Mucoid Impaction Caused by Monokaryotic Mycelium of Schizophyllum commune in Association with Bronchiectasis.

et al. 2000

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“…Schizophyllum commune has elicited serious invasive disease in the brain (5, 41), lungs (6,41,53), and hard and soft palates (40). It has also been implicated in allergic bronchopulmonary disease (1,22), chronic sinusitis (4,25,33,45,51,52), and less serious disease of the nails (27). Coprinopsis cinerea (anamorph, Hormographiella aspergillata) (14,18) has been the causative agent in a case of prosthetic valve endocarditis (13,57) and in a fatal pulmonary infection (60).…”

Section: Few Filamentous Basidiomycetes Have Been Authenticated As Humentioning

confidence: 99%

Identification and First Report of Inonotus ( Phellinus ) tropicalis as an Etiologic Agent in a Patient with Chronic Granulomatous Disease

Sutton¹,

Thompson²,

Rinaldi

et al. 2005

J Clin Microbiol

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“…Schizophyllum commune Fries 1821 (Schizophyllaceae, Aphyllophorales) is one of them and has been described elsewhere as a suspected cause of onychomycosis (16), basidioneuromycosis (2), an allergic bronchopulmonary mycosis (12), mucoid impaction of the bronchi (1, 5), a fungus ball in the lung (27), an ulcerative lesion of the hard palate (23), a brain abscess (24), and several cases of both maxillary and allergic fungal sinusitis (4,6,14,18,25,28,29). A review of cases has been published by Kamei et al (13).…”

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Development of Molecular Methods for Identification of Schizophyllum commune from Clinical Samples

et al. 2001

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In the last 50 years, to our knowledge, only 16 cases of diseases caused by Schizophyllum commune in humans have been reported. Within only 6 months, we found four isolates of this basidiomycetous fungus, obtained from patients suffering from chronic sinusitis. The cultures of the isolated fungi showed neither clamp connections nor fruiting bodies (basidiocarps), which are distinctive features for S. commune, but fast-growing cottony white mycelium only. This was harvested, and DNA was extracted. The internal transcribed spacer region of the ribosomal DNA (rDNA) was amplified with fungus-specific primers, and the PCR products were sequenced. Two strains of S. commune, collected from branches of a European hornbeam (Carpinus betulus) and a tree of heaven (Ailanthus altissima), respectively; four specimens from the herbarium of the Institute of Botany, Karl-Franzens-University Graz; and two strains from internationally known culture collections (CBS 340.81 [ATCC 44201] and CBS 405.96) were investigated in the same way. The sequence data of all strains were compared and showed homology of over 99% in this 660-bp-long fragment of rDNA. With these results, a map of restriction enzyme cutting sites and a primer set specific for S. commune were created for reliable identification of this human pathogenic fungus.Compared to the great number of ascomycetous fungi which are the cause of many diseases, filamentous basidiomycetes that cause infections are reported rarely in the medical literature. Schizophyllum commune Fries 1821 (Schizophyllaceae, Aphyllophorales) is one of them and has been described elsewhere as a suspected cause of onychomycosis (16), basidioneuromycosis (2), an allergic bronchopulmonary mycosis (12), mucoid impaction of the bronchi (1, 5), a fungus ball in the lung (27), an ulcerative lesion of the hard palate (23), a brain abscess (24), and several cases of both maxillary and allergic fungal sinusitis (4,6,14,18,25,28,29). A review of cases has been published by Kamei et al. (13). This worldwide-distributed shelf fungus is found quite frequently in nature throughout the year, although it mostly appears during the cold season (22). The commonly known split-gill fungus is found on decaying wood, where it appears with sessile fan-or kidney-shaped fruiting bodies. Typical for S. commune is the hymenium on the lower side, which consists of longitudinally split gills (lamellae), where masses of basidiospores are produced and released into the air. The fungus is easy to cultivate on most of the media generally used in clinical laboratories. The appearance of fruiting bodies, hyphal clamp connections, and spicules makes identification easy. Nevertheless, monokaryotic clinical isolates lack these unambiguous features, and the mycelium shows up only as a cottony white mass of hyphae without any distinctive marks. In these cases, the fungus is often identified as "Mycelia Sterilia" or misidentified as an ascomycete. In the last few years, many molecular methods, such as PCR, sequencing of segments of the genome,...

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Chronic Maxillary Sinusitis Associated with the Mushroom Schizophyllum commune in a Patient with AIDS

Cited by 65 publications

References 8 publications

Mucoid Impaction Caused by Monokaryotic Mycelium of Schizophyllum commune in Association with Bronchiectasis.

Mucoid Impaction Caused by Monokaryotic Mycelium of Schizophyllum commune in Association with Bronchiectasis.

Identification and First Report of Inonotus ( Phellinus ) tropicalis as an Etiologic Agent in a Patient with Chronic Granulomatous Disease

Development of Molecular Methods for Identification of Schizophyllum commune from Clinical Samples

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