Chronic melatonin treatment reverses disruption of prepulse inhibition in pinealectomized and pinealectomized-plus-ovariectomized rats

Uzbay, Tayfun; Parlakpınar, Hakan; Akdag, Elvin; Çelik, Tuncay; Yararbaş, Görkem; Ulusoy, Kemal Gokhan; Acet, Ahmet; Köse, Ayşe Merve; Kayır, Hakan

doi:10.1016/j.bbr.2012.10.008

Cited by 6 publications

(3 citation statements)

References 60 publications

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“…regarded as a valid exploration when the nose of the mouse was touching the object or was directed toward the object at a distance of no more than 2 cm. Sitting on the object was not considered to be exploratory behavior (20). The relative discrimination index (DI) was calculated by subtracting the exploration time of the familiar object from that of the novel object divided by the total exploration time (21).…”

Section: Vaginal Smear Examinationmentioning

confidence: 99%

Effects of estrogen deprivation on memory and expression of related proteins in ovariectomized mice

et al. 2020

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Background: The ovariectomized (OVX) rodent model is most widely used for studying the influence of estrogen deprivation on memory. However, the results of these studies are inconsistent, in that the memory of OVX rodents shows either impairment or no change. These inconsistent outcomes increase the difficulty of researching neurochemical mechanisms and evaluating drug efficacy. One possible explanation for these discrepancies might be that the time point for memory examination after OVX varies considerably among studies. The aim of our study was to investigate the effects of estrogen deprivation on memory and the expression of memory-related proteins at different times after OVX.Methods: Novel object recognition (NOR), step-through passive avoidance (STPA) and the Morris water maze (MWM) were performed to evaluate the memory performance of mice at different times after OVX.The expressions of BDNF, TrkB, ULK1 and LC3II/LC3I in the hippocampus were also assessed to explore the relevant mechanisms.Results: After OVX, a significant memory impairment was found in the STPA test at 4 weeks. In the NOR and MWM tests, however, memory deficits were not observed until 8 weeks post-OVX. Interestingly, at 8 weeks, a memory rebound was found in the STPA test. In the hippocampus, the levels of BDNF and TrkB in OVX mice were markedly decreased at 4 and 8 weeks. Subsequently, a significant decrease in the ULK1 and LC3II/LC3I level in OVX mice was observed at 8 weeks.Conclusions: Memory impairment in mice was observed as early as 4 weeks after OVX, although there was a possibility of memory rebound with the prolongation of estrogen deprivation. Eight weeks of estrogen deprivation would be more likely to induce hippocampus-dependent memory impairment. This progressive impairment of memory might be due to the downregulation of the BDNF/TrkB signaling pathway at the early post-OVX stage, while the decrease of autophagy level in the later stage might also contribute to these progressive alterations. The underlying relationship between the BDNF/TrkB signaling pathway and autophagy in this progressive impairment of memory requires further study.

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Section: Vaginal Smear Examinationmentioning

confidence: 99%

Effects of estrogen deprivation on memory and expression of related proteins in ovariectomized mice

et al. 2020

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“…All drugs were administered as a single dose. The dosage of ASA and melatonin were selected based on previous dose-response studies [4,23,24]. ASA and melatonin were purchased from Sigma Chemical Co. (St. Louis, MO).…”

Section: Materials and Methods Animals And Experimental Designmentioning

confidence: 99%

“…GSH content was measured as nonprotein sulfhydryls in the liver tissue using the described method described by Uzbay et al (2013). Aliquots of tissue homogenate were mixed with distilled water and 50% trichloroacetic acid in glass tubes and centrifuged at 3000 rpm for 15 min.…”

Section: Gsh Contentmentioning

confidence: 99%

Beneficial effects of melatonin on acetylsalicylic acid induced liver damage in rats

Sarıhan¹,

Parlakpınar²,

Polat³

et al. 2017

Med-Science

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We investigated the effects of acute high doses of acetylsalicylic acid (ASA) on liver tissue and the protective and therapeutic effects of melatonin on ASA related damage. Forty rats were randomly divided into five groups of eight: group 1, control; group 2, administered 200 mg/kg ASA; group 3, administered 5 mg/kg melatonin 45 min before ASA; group 4, administered 5 mg/kg melatonin 45 min after ASA; group 5, administered 5 mg/kg melatonin. We measured malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), myeloperoxidase (MPO) aspartate aminotransferase (AST) and alanine transaminase (ALT) in the liver. ASA treatment significantly increased MDA and MPO production, whereas it significantly decreased levels of SOD, CAT, GPx and GSH in the liver. Melatonin significantly decreased MDA and MPO production, whereas it caused increased levels of antioxidants. AST and ALT levels were higher after ASA treatment, whereas these levels were reduced significantly after melatonin administration. Our histopathological findings, including apoptosis, were consistent with the biochemical results. Melatonin exhibits beneficial effects against high dose ASA induced hepatotoxicity.

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Pharmacotherapy and Emerging Treatment Strategies for Schizophrenia

Sinha

Sachdeva

Ahmad

et al. 2023

Cognizance of Schizophrenia:: A Profound Insight Into the Psyche

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Chronic melatonin treatment reverses disruption of prepulse inhibition in pinealectomized and pinealectomized-plus-ovariectomized rats

Cited by 6 publications

References 60 publications

Effects of estrogen deprivation on memory and expression of related proteins in ovariectomized mice

Effects of estrogen deprivation on memory and expression of related proteins in ovariectomized mice

Beneficial effects of melatonin on acetylsalicylic acid induced liver damage in rats

Pharmacotherapy and Emerging Treatment Strategies for Schizophrenia

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