Chronic meningococcal meningitis. An association with C5 deficiency

Rosen, Michael S.; Lorber, Bennett; Myers, Allen R.

doi:10.1001/archinte.148.6.1441

Cited by 12 publications

(4 citation statements)

References 21 publications

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“…In the study reported by Platonov et al, none of the TCCD patients presenting with invasive meningococcal disease died, and only 39% had severe disease, in comparison with mortality rates of 8% and 61% of severe disease in a control group of individuals without complement deficiencies. Similar observations were reported by other authors (53,175,176).…”

Section: Congenital Immunodeficienciessupporting

confidence: 93%

Epidemiology, Etiology, Pathogenesis, and Diagnosis of Recurrent Bacterial Meningitis

2008

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SUMMARY Recurrent bacterial meningitis is a rare phenomenon and generally poses a considerable diagnostic challenge to the clinician. Ultimately, a structured approach and early diagnosis of any underlying pathology are crucial to prevent further episodes and improve the overall outcome for the affected individual. In this article, we are reviewing the existing literature on this topic over the last two decades, encompassing 363 cases of recurrent bacterial meningitis described in 144 publications. Of these cases, 214 (59%) were related to anatomical problems, 132 (36%) were related to immunodeficiencies, and 17 (5%) were related to parameningeal infections. The review includes a detailed discussion of the underlying pathologies and microbiological aspects as well as recommendations for appropriate diagnostic pathways for investigating this unusual entity.

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Section: Congenital Immunodeficienciessupporting

confidence: 93%

Epidemiology, Etiology, Pathogenesis, and Diagnosis of Recurrent Bacterial Meningitis

2008

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“…C5-deficient patients possibly develop meningococcal meningitis more often than patients with other terminal component deficiency states; otherwise clinical features appear to be similar (70). Few granulocytes were found in initial spinal fluid samples from an unusual C5-deficient patient with chronic meningococcal meningitis (67), which might be ascribed to impaired chemotactic function.…”

Section: Bacterial Infection Encapsulated Bacteria In-mentioning

confidence: 93%

Inherited complement deficiency states: implications for immunity and immunological disease

Sjöholm

1990

APMIS

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The study of complement deficiency states and their influence on immune function has generated new insights and still provides a challenge to continued investigation. The association of classical pathway deficiencies (C1, C4, C2 or C3) with immunological diseases such as SLE and glomerulonephritis has contributed to current knowledge concerning complement‐dependent immune complex handling and elimination. Susceptibility to systemic infection with encapsulated bacteria is encountered in most forms of inherited complement deficiency. Recurrent neisserial infection is the only clinical manifestation clearly associated with defects of the mem‐branolytic sequence C5‐C9, while deficiency of properdin, a component of the alternative activation pathway, appears to predispose to nonrecurrent meningococcal disease. Inherited complement deficiency is rare, but the perspective is widened by the more common occurence of acquired defects in immunological diseases, and the apparent requirement for efficient complement recruitment in host defense. Another aspect is the possibility that complement deficiency might alleviate or prevent inflammatory symptoms. Notably, complement deficiency has not been reported in classical rheumatoid arthritis. Considerations of this kind would be refuted or modified by findings of complement deficiency in single patients.

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“…One patient had C5 deficiency (6), four patients had C6 deficiency (7, 8, 9, this report), two patients had C7 deficiency (8,10), and one patient had properdin deficiency (11). Two of the patients, both children, had a previous history of meningococcal meningitis (6,11). In the remaining patients no additional history of meningococcal disease, recurrent infection, or rheumatologic abnormalities were given.…”

Section: Literature Reviewmentioning

confidence: 81%

Chronic meningococcemia in a child with a deficiency of the sixth component of complement

Fasano

Sullivan

Ibsen

et al. 1993

Pediatric Allergy Immunology

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Chronic meningococcemia represents an uncommon manifestation of meningococcal disease. Microbial and host factors which may predispose to this form of meningococcal disease are not understood. Although acute meningococcal disease is frequently found in patients with terminal complement deficiencies, the relationship of chronic meningococcemia to complement deficiencies is unclear. We present a case report and a review of the literature describing chronic meningococcemia in association with deficiencies of the complement system. A total of eight cases were identified, all of whom were male. Six of the eight patients were children and two of the eight had a previous history of meningococcal disease. This case report, in conjunction with the previously reported cases, suggests an association between complement deficiencies and chronic meningococcemia.

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Chronic meningococcal meningitis. An association with C5 deficiency

Cited by 12 publications

References 21 publications

Epidemiology, Etiology, Pathogenesis, and Diagnosis of Recurrent Bacterial Meningitis

Epidemiology, Etiology, Pathogenesis, and Diagnosis of Recurrent Bacterial Meningitis

Inherited complement deficiency states: implications for immunity and immunological disease

Chronic meningococcemia in a child with a deficiency of the sixth component of complement

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