Chronic mercury at low doses impairs white adipose tissue plasticity

Rizzetti, Danize Aparecida; Corrales, Patricia; Piagette, Janaina; Uranga, José Antonio; Medina-Gómez, Gema; Peçanhã, Franck Maciel; Vassallo, Dalton Valentim; Miguel, Marta; Wiggers, Giulia Alessandra

doi:10.1016/j.tox.2019.02.013

Cited by 25 publications

(28 citation statements)

References 72 publications

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“…Few previous studies have investigated the mechanisms underlying the effects of Hg in dyslipidemia. One possible mechanism involves the homeostasis of lipid metabolism and adipocytes [23]. Adipocytes are involved in lipid metabolism by producing adipokines [24], and Hg reportedly produced functional abnormalities in the adipose tissue of mice [25].…”

Section: Discussionmentioning

confidence: 99%

Association between Dyslipidemia and Mercury Exposure in Adults

Kang

Shin

Kim

2021

IJERPH

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Background—Dyslipidemia is one of the prominent risk factors for cardiovascular disease, which is the leading cause of death worldwide. Dyslipidemia has various causes, including metabolic capacity, genetic problems, physical inactivity, and dietary habits. This study aimed to determine the association between dyslipidemia and exposure to heavy metals in adults. Methods—Using data from the seventh Korean National Health and Nutrition Examination Survey (2016–2017), 5345 participants aged ≥20 years who were tested for heavy metal levels were analyzed in this study. Multiple logistic regression was conducted to assess the factors affecting the prevalence of dyslipidemia. Results—The risks of dyslipidemia among all and male participants with mercury (Hg) levels of ≥2.75 μg/L (corresponding to the Korean average level) were 1.273 and 1.699 times higher than in those with levels of <2.75 μg/L, respectively. The factors that significantly affected the dyslipidemia risk were age, household income, body mass index, and subjective health status in both males and females. Conclusions—In adult males, exposure to Hg at higher-than-average levels was positively associated with dyslipidemia. These results provide a basis for targeted prevention strategies for dyslipidemia using lifestyle guidelines for reducing Hg exposure and healthy behavioral interventions.

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Section: Discussionmentioning

confidence: 99%

Association between Dyslipidemia and Mercury Exposure in Adults

Kang

Shin

Kim

2021

IJERPH

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“…50 Moreover, ω-3 fatty acids and mercury can alter adipokine secretion and modulate inflammatory response through changes in endoplasmic reticulum stress and the peroxisome proliferator-activated receptor signaling pathway. 6,51 Further studies are needed to replicate these results and identify the underlying biological mechanisms that may explain the association of prenatal fish intake and mercury exposure with metabolic health in children.…”

Section: Jama Network Open | Nutrition Obesity and Exercisementioning

confidence: 99%

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

et al. 2020

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IMPORTANCE The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown.OBJECTIVE To assess the associations of fish intake and mercury exposure during pregnancy with metabolic syndrome in children and alterations in biomarkers of inflammation in children. DESIGN, SETTING, AND PARTICIPANTSThis population-based prospective birth cohort study used data from studies performed in 5 European countries (France, Greece, Norway, Spain, and the UK) between April 1, 2003, and February 26, 2016, as part of the Human Early Life Exposome (HELIX) project. Mothers and their singleton offspring were followed up until the children were aged 6 to 12 years. Data were analyzed between March 1 and August 2, 2019.EXPOSURES Maternal fish intake during pregnancy (measured in times per week) was assessed using validated food frequency questionnaires, and maternal mercury concentration (measured in micrograms per liter) was assessed using maternal whole blood and cord blood samples. MAIN OUTCOMES AND MEASURESAn aggregate metabolic syndrome score for children was calculated using the z scores of waist circumference, systolic and diastolic blood pressures, and levels of triglyceride, high-density lipoprotein cholesterol, and insulin. A higher metabolic syndrome score (score range, −4.9 to 7.5) indicated a poorer metabolic profile. Three protein panels were used to measure several cytokines and adipokines in the plasma of children. RESULTSThe study included 805 mothers and their singleton children. Among mothers, the mean (SD) age at cohort inclusion or delivery of their infant was 31.3 (4.6) years. A total of 400 women (49.7%) had a high educational level, and 432 women (53.7%) were multiparous. Among children, the mean (SD) age was 8.4 (1.5) years (age range, 6-12 years). A total of 453 children (56.3%) were boys, and 734 children (91.2%) were of white race/ethnicity. Fish intake consistent with health recommendations (1 to 3 times per week) during pregnancy was associated with a 1-U decrease in metabolic syndrome score in children (β = −0.96; 95% CI, −1.49 to −0.42) compared with low fish consumption (<1 time per week) after adjusting for maternal mercury levels and other covariates. No further benefit was observed with fish intake of more than 3 times per week. A higher maternal mercury concentration was independently associated with an increase in the metabolic syndrome score of their offspring (β per 2-fold increase in mercury concentration = 0.18; 95% CI, 0.01-0.34).Compared with low fish intake, moderate and high fish intake during pregnancy were associated with reduced levels of proinflammatory cytokines and adipokines in children. An integrated analysis identified a cluster of children with increased susceptibility to metabolic disease, which was (continued) Key Points Question Is fish consumption during pregnancy associated with benefits for the metabolic health of children? Findings In this cohort study of 805 mothers and their singleton offspring, ...

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“…Contradictory results were found in literature regarding the effects of mercury on these transcription factors. In 3T3-L1 cell line, inorganic mercury significantly decreased the level of PPARg protein (5 and 10 mM, 48 h) (Barnes et al, 2003) whereas the PPARg mRNA level increased in Hgexposed rats (first dose of 4.6 mg/kg and subsequent doses of 0.07 mg/kg/day, 60 days) (Rizzetti et al, 2019). The implication of these transcription factors in the toxicity of mercury requires further research.…”

Section: Modulation Of Adipocyte Differentiation By Mehgmentioning

confidence: 95%

“…As previously described, this lipid storage might be associated with the adipocyte differentiation induced by the production of ROS as well as the upregulation of lipogenic genes. A recent study showed that chronic mercury contamination (HgCl 2 , first dose of 4.6 mg/kg and subsequent doses of 0.07 mg/kg/day, 60 days) impaired rat epididymal white adipose tissue metabolism even though the mercury concentration in the adipose tissue of treated rats was not significantly different from untreated animals (Rizzetti et al, 2019). The authors suggested the implication of the oxidative and endoplasmic reticulum stresses in adipose tissue.…”

Section: Accumulation Of Neutral Lipids Persisted After the Onset Of mentioning

confidence: 99%

“…On the other hand, MeHg did not affect lipid accumulation in human preadipocytes and mesenchymal stem cells up to 100 nM (van den Dungen et al, 2017). If the impact of MeHg has only been scarcely investigated, several studies highlighted the impairment of adipogenesis by inorganic mercury via in vitro and in vivo experiments in rodents (Barnes et al, 2003;Kawakami et al, 2012;Rizzetti et al, 2019). MeHg has also been shown to affect cellular energy metabolism in other organs.…”

Section: Introductionmentioning

confidence: 99%

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Methylmercury displays pro-adipogenic properties in rainbow trout preadipocytes

et al. 2021

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h i g h l i g h t s MeHg induced a dose-dependent accumulation of neutral lipids in preadipocytes. Accumulation of lipids persisted beyond the cellular exposure to MeHg. MeHg increased n-3 PUFA levels in lipid droplets and dropped AA levels in membranes. Expression of adipocyte-and lipid-specific genes was modulated by MeHg. Total mercury accumulated in cells was released when MeHg exposure stopped.

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Chronic mercury at low doses impairs white adipose tissue plasticity

Cited by 25 publications

References 72 publications

Association between Dyslipidemia and Mercury Exposure in Adults

Association between Dyslipidemia and Mercury Exposure in Adults

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

Methylmercury displays pro-adipogenic properties in rainbow trout preadipocytes

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