2006
DOI: 10.1007/s10194-006-0339-6
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Chronic migraine prevention with topiramate

Abstract: Chronic migraine (CM) is a disabling condition with not many treatment strategies available. Topiramate is effective in episodic migraine prevention, however little is known about its effect in CM. An open label study was performed. Sixty-four patients diagnosed with CM or probable CM according to the IHS diagnostic criteria were enrolled, 50 patients were available for analysis and an intention-to-treat methodology was applied. The primary endpoint considered was the number of patients with a decrease in head… Show more

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Cited by 18 publications
(16 citation statements)
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“…Finally, and related to the previous idea is the perception that these patients were very difficult to treat and refractory to all preventatives. The paper by Peres et al [3] appearing in this issue supports those of us who think that chronic migraine patients may specifically improve with preventatives, especially on topiramate, even if they continue overusing symptomatic treatments.…”
supporting
confidence: 51%
See 1 more Smart Citation
“…Finally, and related to the previous idea is the perception that these patients were very difficult to treat and refractory to all preventatives. The paper by Peres et al [3] appearing in this issue supports those of us who think that chronic migraine patients may specifically improve with preventatives, especially on topiramate, even if they continue overusing symptomatic treatments.…”
supporting
confidence: 51%
“…Peres et al [3] treated 64 chronic migraine patients, both with and without analgesic overuse, with topiramate (median dose 100 mg/day). A reduction in frequency higher than 50% occurred in 66% of these patients after 12 weeks and was not different in overusers vs. those who were not overusers.…”
mentioning
confidence: 99%
“…Pregnancy and renal colic were the reasons for stopping topiramate after more than two years in a total of four patients. On the other hand, our experience surely reflects the results obtained with topiramate in daily practice in headache clinics when treating migraineurs with frequent headaches: around 15% of patients do not tolerate the drug (mainly due to cognitive side effects), 10%-15% do not respond, while the remaining 70% exhibit good (and long-term) efficacy [7,8].…”
Section: Discussionmentioning
confidence: 72%
“…These chronic migraine patients have been shown to respond satisfactorily to topiramate [7,8], even in the presence of overuse and in controlled conditions [9,10]. Interestingly, among the group of responders in long-term treatment there was only one patient whose headaches became worse while on topiramate.…”
Section: Discussionmentioning
confidence: 99%
“…The primary endpoint consisted of the number of patients with a reduction in headache frequency of [50-66% of patients showed such a response, with no difference in the response related to drugs of abuse [32].…”
Section: Topiramatementioning
confidence: 99%