Chronic mild eosinophilia and severe cardiomyopathy

Acute heart failure with dilated cardiomyopathy as the first manifestation of eosinophilic granulomatosis with polyangiitis

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melanogenesis and the melanocyte cell cycle. 5,6 Tryptase activates MMP1 and MMP-9, which degrade type I and IV collagens leading to extracellular matrix degradation (solar elastosis) and basement membrane damage. 7 Mast cells also induce vascular proliferation by secreting VEGF, FGF-2 and TGF-b.

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“…A literature search for English articles in PubMed was conducted using the terms 'eosinophilic granulomatosis with polyangiitis' OR 'Churg-Strauss Syndrome' AND 'dilated cardiomyopathy'. Seven previously reported EGPA cases complicated with DCM [3][4][5][6][7][8][9] together with our case were reviewed and summarized in Table 1.…”