Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats

Grippo, Angela J.; Sullivan, Nicole R.; Damjanoska, Katerina J.; Crane, James W.; Carrasco, Gonzalo; Ju, Shaoqing; Chen, Zhuo; García, Francisca; Muma, Nancy A.; Kar, Louis D. Van de

doi:10.1007/s00213-004-2103-4

Cited by 144 publications

(103 citation statements)

References 52 publications

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“…Depression is associated with altered corticotropinreleasing factor (CRF), elevated hypothalamic-pituitary-adrenal (HPA) axis hormones, and impaired feedback regulation of the HPA axis (Asnis et al, 1987;Banki et al, 1992;Raadsheer et al, 1995;Sullivan Hanley & Van de Kar, 2003;Young et al, 2004). Similar changes, including alterations in corticosterone and adrenocorticotropic hormone (ACTH), impaired feedback control of HPA axis functioning, impaired glucorticoid receptor binding (increased mRNA expression and density of binding sites) in the hippocampus, cortex and dorsal raphe nucleus, and altered CRF input to the dorsal raphe nucleus, have been observed in several validated animal models of depression (Froger et al, 2004;Maier & Watkins, 2005;Grippo et al, 2005a;Grippo et al, 2005b) [but see (Azpíroz et al, 1999) for negative findings regarding circulating corticosterone levels]. Some of these responses are sexually dimorphic, with female rodents possibly showing increased sensitivity to stressors (Dalla et al, 2005).…”

Section: Introductionmentioning

confidence: 86%

Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles

Grippo

Gerena

Huang

et al. 2007

Psychoneuroendocrinology

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302

279

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SummarySupportive social interactions may be protective against stressors and certain mental and physical illness, while social isolation may be a powerful stressor. Prairie voles are socially monogamous rodents that model some of the behavioral and physiological traits displayed by humans, including sensitivity to social isolation. Neuroendocrine and behavioral parameters, selected for their relevance to stress and depression, were measured in adult female and male prairie voles following 4 weeks of social isolation versus paired housing. In Experiment 1, oxytocin-immunoreactive cell density was higher in the hypothalamic paraventricular nucleus (PVN) and plasma oxytocin was elevated in isolated females, but not males. In Experiment 2, sucrose intake, used as an operational definition of hedonia, was reduced in both sexes following 4 weeks of isolation. Animals then received a residentintruder test, and were sacrificed either 10 minutes later for the analysis of circulating hormones and peptides, or two hours later to examine neural activation, indexed by c-Fos expression in PVN cells immunoreactive for oxytocin or corticotropin-releasing factor (CRF). Compared to paired animals, plasma oxytocin, ACTH and corticosterone were elevated in isolated females and plasma oxytocin was elevated in isolated males, following the resident-intruder test. The proportion of cells doublelabeled for c-Fos and oxytocin or c-Fos and CRF was elevated in isolated females, and the proportion of cells double-labeled for c-Fos and oxytocin was elevated in isolated males following this test. These findings suggest that social isolation induces behavioral and neuroendocrine responses relevant to depression in male and female prairie voles, although neuroendocrine responses in females may be especially sensitive to isolation.

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Section: Introductionmentioning

confidence: 86%

Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles

Grippo

Gerena

Huang

et al. 2007

Psychoneuroendocrinology

Self Cite

302

279

View full text Add to dashboard Cite

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“…The relationship between stress and reduced 5-HT 1A receptor function has been documented in several ways. Chronic mild stress reduced adrenocorticotrophic hormone responses to 8-OH-DPAT, a 5-HT 1A receptor agonist (Grippo et al, 2005). Stress reduces 5-HT 1A messenger RNA gene expression in hippocampus in rats (Lopez et al, 1999) and 5-HT 1A receptor binding, as measured by autoradiography, in the hippocampus in rats and humans (Lopez et al, 1998).…”

Section: 12mentioning

confidence: 92%

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Tomie

Grimes

Pohorecky

2008

Brain Research Reviews

153

134

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Drug abuse researchers have noted striking similarities between behaviors elicited by Pavlovian signtracking procedures and prominent symptoms of drug abuse. In Pavlovian sign-tracking procedures, repeated paired presentations of a small object (conditioned stimulus, CS) with a reward (unconditioned stimulus, US) elicits a conditioned response (CR) that typically consists of approaching the CS, contacting the CS, and expressing consummatory responses at the CS. Signtracking CR performance is poorly controlled and exhibits spontaneous recovery and long-term retention, effects that resemble relapse. Sign-tracking resembles psychomotor activation, a syndrome of behavioral responses evoked by addictive drugs, and the effects of sign-tracking on corticosterone levels and activation of dopamine pathways resemble the neurobiological effects of abused drugs. Finally, the neurobiological profile of individuals susceptible to sign-tracking resembles the pathophysiological profile of vulnerability to drug abuse, and vulnerability to sign-tracking predicts vulnerability to impulsive responding and alcohol self-administration. Implications of sign-tracking for models of drug addiction are considered.

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“…The sucrose preference test (SPT) was performed as described previously (Grippo et al, 2005). In brief, an SPT consisted of first removing the food and water from each mouse's cage for a period of 20 h. Water and 1% sucrose were then placed on the cages in preweighed plastic bottles, and animals were allowed to consume the fluids for a period of 10 h. The bottles were then removed and weighed.…”

Section: Chronic Mild Stress and Behavioral Measuresmentioning

confidence: 99%

Hippocampal Telomerase Is Involved in the Modulation of Depressive Behaviors

Zhou¹,

Hu²,

Wu³

et al. 2011

J. Neurosci.

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Telomere and telomerase alterations have been reported in mood disorders. However, the role of telomerase in depression remains unclear. Here we show that chronic mild stress (CMS) led to a significant decrease in telomerase reverse transcriptase (TERT) level and telomerase activity in the hippocampus. Treatment with antidepressant fluoxetine reversed the CMS-induced TERT and telomerase activity changes. Inhibiting telomerase by systemic administration (100 mg ⅐ kg Ϫ1 ⅐ d Ϫ1 , i.p., for 14 d), intrahippocampal microinjection (0.7 mol, 2 l), or infusion (using an osmotic minipump, 0.134 g/l, 0.25 l/h) of 3Ј-azido-deoxythymidine (AZT) resulted in depression-like behaviors and impaired hippocampal neurogenesis in mice. In contrast, overexpressing telomerase by intrahippocampal infusion of recombinant adenovirus vector expressing mouse TERT (Ad-mTERT-GFP) led to neurogenesis upregulation, produced antidepressant-like behaviors, and prevented the CMS-induced behavioral modifications. Disrupting neurogenesis in the dentate gyrus by X-irradiation (15 Gy) of a restricted region of mouse brain containing the hippocampus abolished the antidepressant-like effect of Ad-mTERT-GFP. Additionally, AZT had no effect on DNA polymerase activity and did not cause cell damage in vitro and in vivo. Microinjection of AZT into the subventricular zone of lateral ventricle (0.7 mol, 2 l) inhibited local neurogenesis but had no behavioral effect. These results suggest that hippocampal telomerase is involved in the modulation of depression-related behaviors, possibly by regulating adult neurogenesis.

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Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats

Cited by 144 publications

References 52 publications

Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles

Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Hippocampal Telomerase Is Involved in the Modulation of Depressive Behaviors

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