Chronic Mitral Regurgitation: Left Atrial Deformation Analysis by Two‐Dimensional Speckle Tracking Echocardiography

Cameli, Matteo; Lisi, Matteo; Giacomin, Elisa; Caputo, Maria Luce; Navarri, Romina; Malandrino, Angela; Ballo, Piercarlo; Agricola, Eustachio; Mondillo, Sergio

doi:10.1111/j.1540-8175.2010.01329.x

Cited by 109 publications

(86 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, a negative correlation was found between the above‐mentioned STE‐derived variables and conventional echocardiographic measurements of left cardiac chamber size. These data are in agreement with previous reports focused on conventional echocardiographic assessment of LA function in dogs with MMVD,2, 7 as well as human studies in patients investigated by STE,38, 39, 40, 41, 42, 43, 44 and suggest progressive LA dysfunction with worsening of MMVD and LA dilatation. These findings might be explained by the progressive LA volume overload due to MR and remodeling and by an increase in LV filling pressures in the advanced phases of the disease.…”

Section: Discussionsupporting

confidence: 93%

Assessment of Left Atrial Deformation and Function by 2‐Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease

Toaldo

Romito

Guglielmini

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundThe assessment of left atrial (LA) function by 2‐dimensional speckle tracking echocardiography (STE) holds important clinical implications in human medicine. Few similar data are available in dogs.ObjectivesTo assess LA function by STE in dogs with and without myxomatous mitral valve disease (MMVD), analyzing LA areas, systolic function, and strain.AnimalsOne hundred and fifty dogs were divided according to the American College of Veterinary Internal Medicine classification of heart failure: 23 dogs in class A, 52 in class B1, 36 in class B2, and 39 in class C + D.MethodsProspective observational study. Conventional morphologic and Doppler variables, LA areas, and STE‐based LA strain analysis were performed in all dogs and results were compared among groups. Correlation analysis was carried out between LA STE variables and other echocardiographic variables.ResultsVariability study showed good reproducibility for all the tested variables (coefficient of variation <16%). Left atrial areas, fractional area change, peak atrial longitudinal strain (PALS), peak atrial contraction strain, and contraction strain index (CSI) differed significantly between groups B2 and C + D and all the other groups (overall P < .001), whereas only PALS differed between groups B1 and A (P = .01). Left atrial areas increased with progression of the disease, whereas LA functional parameters decreased. Only CSI increased nonsignificantly from group A to group B1 and then progressively decreased. Thirty‐one significant correlations (P < .001, r > .3) were found between conventional left heart echocardiographic variables and LA areas and strain variables.Conclusions and Clinical ImportanceLeft atrial STE analysis provides useful information on atrial function in the dog, highlighting a progressive decline in atrial function with worsening of MMVD.

show abstract

Section: Discussionsupporting

confidence: 93%

Assessment of Left Atrial Deformation and Function by 2‐Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease

Toaldo

Romito

Guglielmini

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…In mitral regurgitation, PALS by STE was shown to decrease with increasing severity of mitral regurgitation (82) and was an independent predictor of mitral valve surgery and post-operative outcomes. The study by Debonnaire et al investigating 121 patients with severe primary mitral regurgitation demonstrated PALS to have the highest accuracy in identifying patients who proceeded to mitral valve surgery amongst all indices of LA function.…”

Section: Valvular Heart Diseasementioning

confidence: 87%

Left atrial function: evaluation by strain analysis

Gan¹,

Ferkh²,

Boyd

et al. 2018

Cardiovasc. Diagn. Ther.

140

108

View full text Add to dashboard Cite

Abstract:The left atrium has an important role in modulating left ventricular filling and is an important biomarker of cardiovascular disease and adverse cardiovascular outcomes. While previously left atrial (LA) size was utilised, the role of LA function as a biomarker is increasingly being evaluated, both independently and also in combination with LA size. Strain analysis has been utilised for evaluation of LA function and can be measured throughout the cardiac cycle, thereby enabling the evaluation of LA reservoir, conduit and contractile function. Strain evaluates myocardial deformation while strain rate examines the rate of change in strain. This review will focus on the various types of strain analysis for evaluation of LA function, alterations in LA strain in physiological and pathologic states that alter LA function and finally evaluate its utility as a prognostic marker.

show abstract

“…In rheumatic heart disease, a previous rheumatic illness has been shown to play a contributing role in LA and LV dysfunctions (36-38). Cameli et al (39) used a new technique of two-dimensional speckle tracking echocardiography which revealed that indicators of longitudinal LA deformation were increased in mild MR patients; however, they were decreased in moderate and severe MR patients. While the increase in mild MR patients was associated with the increase in LA compliance, the decrease in moderate and severe patients was correlated to chronic MR-related structural abnormalities such as myocyte hypertrophy, interstitial fibrosis, and reduced metalloproteinase secretion.…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of the left atrial myocardial deformation in patients with chronic mitral regurgitation by strain and strain rate imaging: an observational study

Aksakal¹,

Şimşek²,

Sevimli³

et al. 2012

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

show abstract

Chronic Mitral Regurgitation: Left Atrial Deformation Analysis by Two‐Dimensional Speckle Tracking Echocardiography

Abstract: Our study provides new insight for the LA function analysis in response to different degrees of MR, showing that STE measurements of LA longitudinal strain may be considered a promising tool for the early detection of impairment of LA compliance in patients with asymptomatic chronic MR.

Cited by 109 publications

References 34 publications

Assessment of Left Atrial Deformation and Function by 2‐Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease

Assessment of Left Atrial Deformation and Function by 2‐Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease

Left atrial function: evaluation by strain analysis

Quantitative assessment of the left atrial myocardial deformation in patients with chronic mitral regurgitation by strain and strain rate imaging: an observational study

Contact Info

Product

Resources

About