Chronic myelocytic leukemic fundus lesion: A case report

Abstract

Abstract. The current study reports a case of a patient with a chronic myelocytic leukemic fundus lesion, initially diagnosed in the Department of Ophthalmology, Rizhao People's Hospital (Rizhao, China). A male, 23-years-of-age, presented with a dark shadow in the front of the right eye, accompanied with blurred vision for 3 days (visual acuity of right eye, 0.4; visual acuity of left eye, 0.6). In addition, the patient had experienced gingival bleeding for 2 years, and recurrent upper respiratory infections for 1 year. A fundus examination revealed mild binocular papillary edema, dilated and tortuous veins, and the retina exhibited large quantities of scattered and dark red bleeding spots. The bleeding spots had white spots in the center, which exhibited typical Roth spots, whilst routine blood examination, abdominal ultrasound, marrow biopsy and other laboratory tests confirmed the diagnosis of chronic myelogenous leukemia. Patients with leukemia typically present with initial symptoms that include fever, fatigue, anemia and hepatosplenomegaly, and a diagnosis as a result of eye-related symptoms is rare, rendering the present case unique.

Miliary microaneurysms: An angiographic biomarker of leukemic retinopathy?

“…[ 1 2 ] Presence of multiple microaneurysms in those cases as well as in previous reports draws one's attention. [ 3 4 ] Jampol et al . [ 5 ] have described these findings back in 1975 in a series of 25 patients with CML and chronic lymphocytic leukemia.…”

“…Presence of such MAs in leukemic retinopathy has been described in few case reports and case series. [ 1 2 3 4 5 ]…”