Chronic myelogenous leukaemia with persistent neutrophilia, eosinophilia and basophilia in a cat

Abstract

Chronic myelogenous leukaemia was diagnosed in a 7-year-old male neutered domestic shorthair cat. Leukocytosis (74,900/µl)--mature neutrophilia, eosinophilia and basophilia--was observed. Bone marrow aspiration revealed hypercellularity with proliferation of cells of myeloid lineage. An underlying condition leading to leukocytosis was not identified. The severe leukocytosis did not respond to antibiotic therapy. Based on these findings, chronic myelogenous leukaemia was diagnosed. Because of the absence of clinical signs, the cat was monitored without treatment until 7 months after diagnosis, when it developed pruritic skin lesions. Pruritus was controlled with oral prednisolone. Forty-two months after diagnosis, the cat developed nasal lymphoma, which was treated with radiation therapy, resulting in complete remission. The cat was still in good physical condition 63 months after diagnosis, despite the persistence of marked neutrophilia, eosinophilia and basophilia.

Marked paraneoplastic basophilia accompanying eosinophilia in a cat with alimentary T-cell lymphoma

“…In cats, paraneoplastic basophilia has previously been reported with intestinal and epitheliotropic lymphoma of T-cell origin, 1 , 2 feline large granular lymphocyte lymphoma, 8 acute and chronic myelogenous leukaemia, 3 , 4 and malignant mesenchymal tumour. 5 …”

“…Paraneoplastic basophilia and eosinophilia in cats have been rarely reported together, predominantly with haemolymphatic malignancies, and usually accompanied by clinical signs of GI disease. 1 – 4 Feline basophils had mild-to-moderate increases, ranging from 0.2 × 10 9 /l with chronic myeloid leukaemia, 4 0.28 × 10 9 /l with the acute form, 3 and up to 0.58 × 10 9 /l with intestinal T-cell lymphoma. 2 The highest reported value was 2.8 × 10 9 /l, 1 also documented in a case of intestinal lymphoma.…”

Paraneoplastic neutrophilic leukocytosis syndrome in a cat with recurrent mammary carcinoma

“…Thus, bone marrow examination would not be helpful in the discrimination of CML from PLNS, as both of these diseases stimulate bone marrow and produce marked granulocytic hyperplasia with an increased M:E ratio. 11 , 14 …”

“…Thus, bone marrow examination would not be helpful in the discrimination of CML from PLNS, as both of these diseases stimulate bone marrow and produce marked granulocytic hyperplasia with an increased M:E ratio. 11,14 The precise origin of PNLS in medicine is not readily understood; however, in dogs and cats the production of G-CSF or GM-CSF from tumor cells might represent a potential mechanism. 3 PCR and immunohistochemistry have been used as confirmatory methods of the positive expression of these proteins from tumor cells.…”

Extreme Neutrophilie bei der Katze – Ätiologie und Prognose

“…In der Literatur gibt es hierzu einzelne Berichte bei der Katze mit beispielsweise einer chronischen myelomonozytären Leukämie (16) oder einer chronischen eosinophilen Leukämie (3). Ferner findet sich ein Fallbericht über eine chronische myeloische Leukämie mit persistierender dominierender Neutrophilie (> 60 x 10 9 /l), Eosinophilie und Basophilie bei der Katze (10). Zu beachten ist, dass es sich bei der Diagnosestellung einer chronischen myeloischen Leukämie in der Veterinärmedizin um eine reine Ausschlussdiagnose handelt.…”