Chronic Myeloid Leukemia

and, Irene A.G. Roberts; Dokal, Inderjeet

doi:10.1002/9780470987001.ch17

Cited by 3 publications

(3 citation statements)

References 165 publications

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“…CML in childhood presents as one of the two clinically distinct syndromes, i.e., adult-type CML (ATCML), which is Ph 1 -positive, and juvenile CML, also known as Juvenile Myelomonocytic Leukemia (JMML), which is Ph 1 -negative [4]. Though ATCML or Ph 1 -positive CML is more common in children, it is very rarely encountered below the age of 5 years, whereas JMML is more common [1].…”

Section: Discussionmentioning

confidence: 99%

Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in A Child: A Case Report

Mishra

Tripathi

Mohanty

et al. 2010

Indian J Hematol Blood Transfus

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Section: Discussionmentioning

confidence: 99%

Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in A Child: A Case Report

Mishra

Tripathi

Mohanty

et al. 2010

Indian J Hematol Blood Transfus

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“…Next, we examined current diagnostic criteria for diseases in which well-accepted criteria exist, namely CML, 7 JMML, 8 ET, 9 PV, 10 and IMF. [11][12][13] We then retrospectively applied these criteria to our patients for two reasons: first to determine whether some patients who were diagnosed in the early years of the study would fulfill the possibly more rigorous diagnostic standards that apply today, and second to assess the suitability of these diagnostic criteria for children, since these criteria, with the exception of JMML and TMD of Down syndrome, were derived from studies examining the adult population.…”

Section: Methodsmentioning

confidence: 99%

A Basic Classification and a Comprehensive Examination of Pediatric Myeloproliferative Syndromes

Gassas

Doyle

Weitzman

et al. 2005

Journal of Pediatric Hematology/Oncology

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Myeloproliferative syndromes (MPSs) are clonal stem cell disorders resulting in excessive proliferation of one or more cell lineages. Since MPSs in children occur much less commonly than adults, one can argue that the biology and the categories of the various pediatric MPSs seem to be different from adults. Furthermore, confusion exists between pediatric MPS and other overlapping conditions, such as myelodysplastic syndrome. The authors' objectives were to develop a classification system with a list of disorders relevant to children and to characterize pediatric cases of MPS that were devised according to this classification. Based on the predominant proliferating cell lineage, the authors established a classification system for childhood MPS. Primary MPS was classified into granulocytic proliferation--chronic myelogenous leukemia (CML); monocytic--juvenile myelomonocytic leukemia (JMML); megakaryocytic--essential thrombocythemia (ET), familial thrombocytosis, transient myeloproliferative disorder of Down syndrome (TMD); erythrocytic--polycythemia vera, familial erythrocytosis; fibroblastic--idiopathic myelofibrosis (IMF); eosinophilic--idiopathic hypereosinophilic syndrome (IHES); and mast cells--mastocytosis. Secondary MPS was classified as non-clonal proliferation (eg, infections, drugs, toxins, autoimmune, non-hematologic neoplasm, and trauma), and these were excluded from the study. Next, the classification system was applied to the patient population at the authors' institution. One hundred two cases with primary MPS were identified between 1970 and 2001. Patients were evaluated for clinical manifestations, blood and bone marrow parameters, cytogenetics, and survival following different treatment modalities. Significant proportions of cases of childhood MPS (60%) were unique to the pediatric population and not seen in adults. The most common disorders were JMML (n = 31), TMD of Down syndrome (n = 30), and CML (n = 30); the other disorders were rare: four cases of ET, two of IMF, two of IHES, two of mastocytosis, and one primary erythrocytosis. In contrast to adults, MPS in children is more frequently treated with hematopoietic stem cell transplantation (HSCT), the only available curative option for most of these diseases. HSCT was particularly successful in the more recent cases due to more advanced techniques for HSCT. The authors found that all the cases could be easily classified. MPS in children is different from adult-type MPS in terms of biology, categories, classification, and prognosis.

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“…The main finding on examination is splenomegaly. There is anecdotal evidence that leucostasis is more common in children (1). Limited published data suggest the haematological features in children are very similar to those in adults: peripheral blood leucocytosis, eosinophilia and basophilia, marrow hypercellularity with a characteristic myelocyte 'peak'; normal or moderately increased platelets; anaemia has been reported to be more common in children with CML (1).…”

Section: Roberts (London Uk)mentioning

confidence: 99%

Plenary Lecture 1

2002

Bone Marrow Transplant

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Chronic Myeloid Leukemia

Cited by 3 publications

References 165 publications

Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in A Child: A Case Report

Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in A Child: A Case Report

A Basic Classification and a Comprehensive Examination of Pediatric Myeloproliferative Syndromes

Plenary Lecture 1

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