Chronic myeloid leukemia presenting with bilateral central retinal vein occlusion and massive retinal infiltrates

Goel, Neha; Pangtey, Bhanu; Thakar, Meenakshi; Raina, Usha K; Ghosh, Basudeb

doi:10.1016/j.jaapos.2012.04.006

Cited by 27 publications

(35 citation statements)

References 7 publications

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“…Visual disturbances may be the presenting symptoms in patients with MPN (Goel et al. ). Cotton‐wool spots and haemorrhages in the retina are common findings (Nobacht et al.…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive imaging of retinal blood flow in myeloproliferative neoplasms

Willerslev

Hansen

Klefter

et al. 2016

Acta Ophthalmologica

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With non-invasive retinal imaging, we were able to demonstrate increased retinal venous blood velocity, increased retinal arterial blood oxygenation and normalization of intravascular reflectivity patterns after successful treatment of myeloproliferative neoplasms. Larger prospective studies are needed to assess the prognostic value of these non-invasive imaging methods in predicting circulatory complications in myeloproliferative neoplasms.

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“…Visual disturbances may be the presenting symptoms in patients with MPN (Goel et al. ). Cotton‐wool spots and haemorrhages in the retina are common findings (Nobacht et al.…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive imaging of retinal blood flow in myeloproliferative neoplasms

Willerslev

Hansen

Klefter

et al. 2016

Acta Ophthalmologica

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“…Hemorrhage may occur at all levels of the retina, usually in the posterior pole, and may extend into the vitreous. The presence of microaneurysms and central retinal vein occlusion are related increased viscosity from elevated leukocyte count in CML . In the present study, retinal abnormalities were determined when the patients were observed in the context of symptoms.…”

Section: Discussionmentioning

confidence: 93%

“…The presence of microaneurysms and central retinal vein occlusion are related increased viscosity from elevated leukocyte count in CML. [25,26] In the present study, retinal abnormalities were determined when the patients were observed in the context of symptoms. In a prospective ophthalmic evaluation, a higher prevalence of retinal changes (39.5%; 15 out of 38 cases) was observed [24] when compared with the present study (5.9%; 14 out of 237 cases) in newly diagnosed CML.…”

Section: Discussionmentioning

confidence: 99%

Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group

Kurosawa

Tanizawa

Tono

et al. 2015

Pediatr Blood Cancer

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“…In patients with CML who present with isolated ocular manifestations, TKI therapy with concomitant ocular surgical intervention has often resulted in improvement in visual acuity and other ocular symptoms 7, 8, 9, 10, 11. Huang et al reported a case of 30 year old male who presented with bilateral multilayer retinal hemorrhage with visual acuities of 20/20 OD and 20/100 OS 7 .…”

Section: Discussionmentioning

confidence: 99%

“…To date, nine cases have been reported in which the ocular manifestations of CML were the only presenting signs of the disease, however, in all of these cases, ocular involvement was described bilaterally 7, 8, 9, 10, 11. In addition, the disease risk stratification of these patients with CML and symptomatic ocular presentations was not discussed.…”

Section: Introductionmentioning

confidence: 99%

A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy

Seraly

Gupta

Mehmi

et al. 2019

American Journal of Ophthalmology Case Reports

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PurposeTo report a case of unilateral leukemic retinopathy secondary to chronic myeloid leukemia (CML).ObservationsPatient presented to clinic with a visual acuity (VA) of 20/200 in the right eye (OD) after several months of progressive monocular vision loss and was found to have dense pre-retinal hemorrhage. Patient underwent 23-gauge pars plana vitrectomy to clear the preretinal hemorrhage along with a complex macula-off retinal detachment repair to address retinal tear and multilayer retinal hemorrhage. The patient was subsequently diagnosed with CML as she was found to be positive for the fusion protein of break point cluster gene (BCR) with Abelson tyrosine kinase (ABL1), BCR-ABL1, upon systemic work-up. Imatinib therapy resulted in complete hematologic and cytogenetic resolution after one month, however, the patient's vision remained unchanged six months after surgery.Conclusion and importanceTo the authors' knowledge, this is the first reported case of unilateral leukemic retinopathy secondary to low risk CML, as determined by the Sokal and Hasford prognostic scoring systems. CML should be included in the differential diagnosis of patients with progressive monocular vision loss with suspicious multi-layer retinal compromise.

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Chronic myeloid leukemia presenting with bilateral central retinal vein occlusion and massive retinal infiltrates

Cited by 27 publications

References 7 publications

Non‐invasive imaging of retinal blood flow in myeloproliferative neoplasms

Non‐invasive imaging of retinal blood flow in myeloproliferative neoplasms

Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group

A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy

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